Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8+ T Cell Activity

scientific article published on September 22, 2010

Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8+ T Cell Activity is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...512894Y
P356DOI10.1371/JOURNAL.PONE.0012894
P953full work available at URLhttp://dx.plos.org/10.1371/journal.pone.0012894
https://europepmc.org/articles/PMC2943924
https://europepmc.org/articles/PMC2943924?pdf=render
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012894&type=printable
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877570/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877570/pdf/?tool=EBI
P932PMC publication ID2943924
P698PubMed publication ID20877570
P5875ResearchGate publication ID46579663

P2093author name stringNobuhiko Katunuma
Naozumi Ishimaru
Yoshio Hayashi
Rieko Arakaki
Akiko Yamada
P2860cites workDefective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic MiceQ61140426
Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamideQ70765881
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8+ T cell cytotoxic effector functionQ73369992
Prevention of spontaneous autoimmune diabetes in NOD mice by transferring in vitro antigen-pulsed syngeneic dendritic cellsQ73622000
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null miceQ74595052
Control of intestinal inflammation by regulatory T cellsQ77291202
Cyclophosphamide-induced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cellsQ79326703
Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complexQ27620728
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
Where CD4+CD25+ T reg cells impinge on autoimmune diabetesQ28506933
Cathepsin S inhibitor prevents autoantigen presentation and autoimmunityQ28591251
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfQ29619194
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouseQ33653550
Lysosomal cysteine proteases: more than scavengersQ33857460
The NOD mouse model of type 1 diabetes: as good as it gets?Q33865111
Cathepsin L is essential for onset of autoimmune diabetes in NOD miceQ34014524
The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.Q34452348
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune diseaseQ34556560
Cathepsin L activity controls adipogenesis and glucose toleranceQ34654358
Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetesQ34756826
Processing and activation of lysosomal proteinasesQ35055169
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivoQ35558255
The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD miceQ36079920
The lysosomal cysteine proteases in MHC class II antigen presentationQ36266499
The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexesQ36266503
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligandsQ36370268
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesionQ36399063
Cysteine cathepsins: multifunctional enzymes in cancerQ36600996
The role of cystatins in cells of the immune systemQ36650672
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetesQ36755911
Cathepsins: key modulators of cell death and inflammatory responsesQ37257916
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivoQ37346696
Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complicationsQ37512877
Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle massQ40116203
A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentationQ40746014
MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activityQ40790715
Dipeptidyl peptidase I and granzyme A are coordinately expressed during CD8+ T cell development and differentiation.Q41031849
The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cellsQ41255658
Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.Q41335222
Dipeptidyl peptidase I is enriched in granules of in vitro- and in vivo-activated cytotoxic T lymphocytes.Q42511999
Splenic cathepsin L is maturated from the proform by interferon-gamma after immunization with exogenous antigensQ43591493
Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processingQ43591595
Cyclophosphamide-induced diabetes in NOD/WEHI mice. Evidence for suppression in spontaneous autoimmune diabetes mellitusQ43863707
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesisQ45232044
Drak2 overexpression results in increased beta-cell apoptosis after free fatty acid stimulationQ46382236
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.Q52584877
DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After TransplantationQ58088388
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e12894
P577publication date2010-09-22
P1433published inPLOS OneQ564954
P1476titleCathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity
Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8+ T Cell Activity
P478volume5

Reverse relations

cites work (P2860)
Q34880003A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization.
Q36543714Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes
Q33920338Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models.
Q52573372Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials.
Q35098737Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases
Q47101639Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes
Q36016293Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes
Q58066739HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction
Q64071659Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells
Q93064841Lysosomes as a therapeutic target
Q34983677Testing agents for prevention or reversal of type 1 diabetes in rodents
Q38235294The Roles of Lysosomes in Inflammation and Autoimmune Diseases

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