Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

scientific journal article

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI14682
P932PMC publication ID151084
P698PubMed publication ID12163455

P2093author name stringNobuhiko Katunuma
Naozumi Ishimaru
Ichiro Saito
Kumiko Yanagi
Yoshio Hayashi
Rieko Arakaki
Kaoru Saegusa
Kouichi Ogawa
P2860cites workHuman cathepsin S: chromosomal localization, gene structure, and tissue distributionQ24310666
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glandsQ24312174
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loadingQ24328923
Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigenQ24595305
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophagesQ24676370
Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin LQ24678337
Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine proteaseQ28117779
A new animal model for primary Sjögren's syndrome in NFS/sld mutant miceQ28504572
Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosisQ28505200
Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndromeQ28506373
Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndromeQ28587895
Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosisQ28590287
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
Role for intracellular proteases in the processing and transport of class II HLA antigensQ33578498
Bioenergetics of immune functions: fundamental and therapeutic aspectsQ33877011
Stimulation of T cells by antigen-presenting cells is kinetically controlled by antigenic peptide binding to major histocompatibility complex class II moleculesQ34499456
A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiationQ35818863
Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interfaceQ36367143
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphismQ36380525
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentationQ36475793
Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complexQ36555812
Cathepsin S activity regulates antigen presentation and immunityQ37382422
Sjögren's syndrome. Proposed criteria for classificationQ39790521
Antigen presentation. Getting peptides into MHC class II moleculesQ40629975
MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activationQ40807437
Diagnostic criteria and immunopathogenesis of Sjögren's syndrome: implications for therapyQ40957254
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathwayQ41020969
Class II antigen expression by lacrimal epithelial cells. An updated working hypothesis for antigen presentation by epithelial cellsQ41152601
Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomesQ41515448
Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo.Q41520444
Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cellsQ41561517
Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexesQ41621208
Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chainQ41653246
Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chainsQ41680884
MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen bindingQ41941589
Inhibition by leupeptin and antipain of the intracellular proteolysis of Ii.Q41946100
HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxinQ59083904
TNF is here to stay!Q61819239
Class II MHC antigen expression on epithelial cells of salivary glands from patients with Sjögren's syndromeQ68835769
Induction of experimental autoallergic sialadenitisQ69126226
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitroQ70136099
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivoQ70136102
Expression of histocompatibility antigen HLA-DR by salivary gland epithelial cells in Sjögren's syndromeQ70304887
Participation of cathepsin B in processing of antigen presentation to MHC class IIQ70494348
Specific assay method for the activities of cathepsin L-type cysteine proteinasesQ72411002
Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunityQ72565150
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjögren's syndromeQ74108365
Mechanisms of neonatal tolerance induced in an animal model for primary Sjögren's syndrome by intravenous administration of autoantigenQ74267251
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null miceQ74595052
Fas ligand-mediated exocrinopathy resembling Sjögren's syndrome in mice transgenic for IL-10Q74595808
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectMucin 19Q21985138
Cathepsin SQ22677356
P304page(s)361–369
P577publication date2002-08-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleCathepsin S inhibitor prevents autoantigen presentation and autoimmunity
P478volume110

Reverse relations

cites work (P2860)
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Q92382240Cathepsin G and Its Role in Inflammation and Autoimmune Diseases
Q33705115Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8+ T Cell Activity
Q34014524Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
Q33765990Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Q51719566Cathepsin S inhibition lowers blood glucose levels in mice.
Q46803900Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease
Q37294866Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis
Q39593840Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.
Q91997273Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome
Q34310225Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm
Q34600485Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy
Q35621386Fluorescent probes for proteolysis: tools for drug discovery
Q36996406GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity
Q30781352Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome
Q28084887Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases
Q62398516Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients
Q34735358Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse
Q91565357Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome
Q41140614Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome
Q26997316Intracellular nucleic acid sensors and autoimmunity
Q24799214Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis
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Q35027428“Venopathy” at work: recasting neointimal hyperplasia in a new light

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