MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis

scientific article

MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/CVR/CVQ042
P932PMC publication ID2883897
P698PubMed publication ID20139113
P5875ResearchGate publication ID41413626

P50authorStephen J WhiteQ43373154
Jason Lee JohnsonQ43990039
Helen WilliamsQ63620267
P2093author name stringChristopher L Jackson
Sarah J George
P2860cites workA presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctionsQ24294366
MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferationQ82284786
Pathology of the vulnerable plaqueQ83187650
Apolipoprotein C-II is a novel substrate for matrix metalloproteinasesQ28284044
Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14.Q33355065
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.Q33878896
Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteriesQ34098485
Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regressionQ35070765
N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis?Q35786965
Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzymeQ35796049
Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinasesQ36882797
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzymeQ37362401
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1.Q38807097
Soluble N-cadherin overexpression reduces features of atherosclerotic plaque instabilityQ39999043
ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cellsQ40323023
Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinasesQ40446304
The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cellsQ40694935
Plasmin produces an E-cadherin fragment that stimulates cancer cell invasionQ40740891
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.Q40838158
Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matricesQ43600816
Plasmin-mediated fibroblast growth factor-2 mobilisation supports smooth muscle cell proliferation in human saphenous vein.Q43740465
Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53.Q43974040
Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3.Q44157813
Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosisQ44523735
Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathwayQ44680897
Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.Q45003769
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin.Q45938289
Transforming growth factor-beta is activated by plasmin and inhibits smooth muscle cell death in human saphenous veinQ46471567
Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferationQ47875422
Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion.Q52544292
Comparison of vascular smooth muscle cell apoptosis and fibrous cap morphology in symptomatic and asymptomatic carotid artery disease.Q52548882
N-cadherin-dependent cell-cell contacts promote human saphenous vein smooth muscle cell survival.Q52563236
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.Q53606830
Allele-specific regulation of matrix metalloproteinase-7 promoter activity is associated with coronary artery luminal dimensions among hypercholesterolemic patientsQ57607763
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosisQ59276652
Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosisQ64377816
Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transferQ64378618
The association of platelet-derived growth factor receptor expression, plaque morphology and histological features with symptoms in carotid atherosclerosisQ73593128
Role of smooth muscle cell death in advanced coronary primary lesions: implications for plaque instabilityQ77792632
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitorsQ80344477
P433issue1
P921main subjectapoptotic processQ14599311
P304page(s)137-146
P577publication date2010-02-05
P1433published inCardiovascular ResearchQ4642329
P1476titleMMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis
P478volume87

Reverse relations

cites work (P2860)
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Q54361733Association of a functional polymorphism in the MMP7 gene promoter with susceptibility to vulnerable carotid plaque in a Han Chinese population.
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Q50077490FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).
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