Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea

scientific article

Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1990PNAS...87.9883T
P356DOI10.1073/PNAS.87.24.9883
P932PMC publication ID55278
P698PubMed publication ID2263639
P5875ResearchGate publication ID20891711

P2093author name stringRajewsky MF
Thomale J
Nehls P
Huh NH
Eberle G
P2860cites workIsolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanineQ24336908
cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cellsQ24337212
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The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesisQ34193304
Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferaseQ34317915
Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.Q34670992
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodiesQ35035714
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamineQ36255316
Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coliQ36294780
Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by EthylnitrosoureaQ37432864
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agentsQ37674355
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesisQ37685706
DNA-carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxides studied by biochemical and biophysical techniquesQ38228999
Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferaseQ39681347
Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virusQ40271272
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.Q40499132
A new pathway for DNA repair in Escherichia coliQ40775216
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cellsQ41614931
Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linkedQ41742698
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine).Q41750608
Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanineQ42208524
Alkylation of DNA in F344 rat thymus following administration of 1-n-propyl-1-nitrosourea in vivo and comparison of O6-alkylguanine DNA alkyltransferase activity in thymus from F344 and Long-Evans rats in vitroQ42213906
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.Q47982249
Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cellsQ48146938
Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissuesQ48348433
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in cultureQ48369340
When do carcinogen-treated 10T1/2 cells acquire the commitment to form transformed foci?Q51247516
Increased O6-alkylguanine alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents.Q53524249
Genetic and molecular mechanisms of the in vitro transformation of Syrian hamster embryo cells by the carcinogen N-ethyl-N-nitrosourea II. Correlation of morphological transformation, enhanced fibrinolytic activity, gene mutations, chromosomal alterQ53541427
Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents.Q53545106
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.Q53556700
Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs.Q53556776
Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine.Q53564607
A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography.Q53576351
Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats.Q53611690
Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines.Q54256756
Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells.Q54346444
Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells.Q54349865
A simple, rapid, and sensitive DNA assay procedureQ56879279
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strainsQ59085307
Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell cultureversus in vivo conditionsQ68347252
DNA ethylation in hamster tissues during subchronic diethylnitrosamine administration and in the hamster trachea after acute diethylnitrosamine administrationQ69588150
Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lungQ70085417
O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumorsQ71250397
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNAQ71431200
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosoureaQ71507682
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)9883-9887
P577publication date1990-12-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRepair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea
P478volume87

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cites work (P2860)
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Q36740954Crystal and solution structures of d(CGC[e6G]AATTCGCG)-drug complexes reveal conformational polymorphism of O6-ethyl-guanine:cytosine base pair
Q28376920DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance
Q35877947Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea
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