scholarly article | Q13442814 |
P819 | ADS bibcode | 1990PNAS...87.9883T |
P356 | DOI | 10.1073/PNAS.87.24.9883 |
P932 | PMC publication ID | 55278 |
P698 | PubMed publication ID | 2263639 |
P5875 | ResearchGate publication ID | 20891711 |
P2093 | author name string | Rajewsky MF | |
Thomale J | |||
Nehls P | |||
Huh NH | |||
Eberle G | |||
P2860 | cites work | Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine | Q24336908 |
cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells | Q24337212 | ||
Regulation and expression of the adaptive response to alkylating agents | Q28289093 | ||
The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis | Q34193304 | ||
Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase | Q34317915 | ||
Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA. | Q34670992 | ||
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies | Q35035714 | ||
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine | Q36255316 | ||
Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli | Q36294780 | ||
Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea | Q37432864 | ||
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents | Q37674355 | ||
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis | Q37685706 | ||
DNA-carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxides studied by biochemical and biophysical techniques | Q38228999 | ||
Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase | Q39681347 | ||
Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virus | Q40271272 | ||
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA. | Q40499132 | ||
A new pathway for DNA repair in Escherichia coli | Q40775216 | ||
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells | Q41614931 | ||
Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked | Q41742698 | ||
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine). | Q41750608 | ||
Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine | Q42208524 | ||
Alkylation of DNA in F344 rat thymus following administration of 1-n-propyl-1-nitrosourea in vivo and comparison of O6-alkylguanine DNA alkyltransferase activity in thymus from F344 and Long-Evans rats in vitro | Q42213906 | ||
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA. | Q47982249 | ||
Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells | Q48146938 | ||
Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues | Q48348433 | ||
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture | Q48369340 | ||
When do carcinogen-treated 10T1/2 cells acquire the commitment to form transformed foci? | Q51247516 | ||
Increased O6-alkylguanine alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents. | Q53524249 | ||
Genetic and molecular mechanisms of the in vitro transformation of Syrian hamster embryo cells by the carcinogen N-ethyl-N-nitrosourea II. Correlation of morphological transformation, enhanced fibrinolytic activity, gene mutations, chromosomal alter | Q53541427 | ||
Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents. | Q53545106 | ||
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. | Q53556700 | ||
Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs. | Q53556776 | ||
Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine. | Q53564607 | ||
A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography. | Q53576351 | ||
Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. | Q53611690 | ||
Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. | Q54256756 | ||
Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells. | Q54346444 | ||
Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells. | Q54349865 | ||
A simple, rapid, and sensitive DNA assay procedure | Q56879279 | ||
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains | Q59085307 | ||
Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell cultureversus in vivo conditions | Q68347252 | ||
DNA ethylation in hamster tissues during subchronic diethylnitrosamine administration and in the hamster trachea after acute diethylnitrosamine administration | Q69588150 | ||
Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung | Q70085417 | ||
O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors | Q71250397 | ||
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA | Q71431200 | ||
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea | Q71507682 | ||
P433 | issue | 24 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 9883-9887 | |
P577 | publication date | 1990-12-01 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea | |
P478 | volume | 87 |
Q27642113 | Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342 |
Q36740954 | Crystal and solution structures of d(CGC[e6G]AATTCGCG)-drug complexes reveal conformational polymorphism of O6-ethyl-guanine:cytosine base pair |
Q28376920 | DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance |
Q35877947 | Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea |
Q28388914 | Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposure |
Q41979852 | High susceptibility of analbuminemic rats to neurogenic tumor induction by transplacental administration of N-ethyl-N-nitrosourea |
Q37476708 | Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors |
Q46645225 | Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol |
Q53420486 | Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. |
Q40506199 | Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences |
Q42556224 | N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult rats |
Q36414865 | O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis |
Q55031679 | Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O(6)-methylguanine-DNA methyltransferase. |
Q37313222 | Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes |
Q31390340 | Role of DNA repair in carcinogen-induced ras mutation |
Q40473972 | Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase |
Q34711951 | Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II. |
Q41006885 | Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms. |
Q42826973 | p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine |