scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1031613445 |
P356 | DOI | 10.1038/288724A0 |
P953 | full work available at URL | http://www.nature.com/articles/288724a0 |
http://www.nature.com/articles/288724a0.pdf | ||
P698 | PubMed publication ID | 6256643 |
P2093 | author name string | R. S. Day | |
S. M. Galloway | |||
A. S. Lubiniecki | |||
S. A. Meyer | |||
G. D. Bynum | |||
Anthony J. Girardi | |||
Anthony S. Lubiniecki | |||
Chuck H. J. Ziolkowski | |||
Dominic A. Scudiero | |||
Gaither D. Bynum | |||
Rufus S. Day | |||
Sharon A. Meyer | |||
Sheila M. Galloway | |||
C. H. Ziolkowski | |||
D. A. Scudiero | |||
A. J. Girardi | |||
P2860 | cites work | Cancer Research | Q326097 |
HeLa cell variants that differ in sensitivity to monofunctional alkylating agents, with independence of cytotoxic and mutagenic responses | Q34038406 | ||
Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C. | Q34202735 | ||
Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines | Q35755371 | ||
Factors involved in differential Giemsa-staining of sister chromatids | Q36707019 | ||
Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange | Q39351911 | ||
An Improved Method of Fixation For Immunofluorescent Detection of SV40 T-Antigen in Infected Human Fibroblasts | Q39930007 | ||
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells | Q41614931 | ||
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5 | Q41645066 | ||
Selectivity of the excision of alkylation products in a xeroderma pigmentosum-derived lymphoblastoid line | Q41699991 | ||
Cellular reactivation of ultraviolet-irradiated human adenovirus 2 in normal and xeroderma pigmentosum fibroblasts | Q44194508 | ||
New Giemsa method for the differential staining of sister chromatids | Q45120605 | ||
Human tumor cell strains defective in the repair of alkylation damage. | Q53578644 | ||
Sister chromatid exchange as an indicator of mutagenesis | Q54587790 | ||
Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cells | Q59084518 | ||
Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts | Q59093825 | ||
Induction of sister chromatid exchanges in xeroderma pigmentosum cells after exposure to ultraviolet light | Q67045661 | ||
SV40-INDUCED TRANSFORMATION OF HUMAN DIPLOID CELLS: CRISIS AND RECOVERY | Q78343268 | ||
P433 | issue | 5792 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | DNA repair | Q210538 |
P304 | page(s) | 724-7 | |
724-727 | |||
P577 | publication date | 1980-12-01 | |
1980-12-25 | |||
P1433 | published in | Nature | Q180445 |
P1476 | title | Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains | |
P478 | volume | 288 |
Q54605966 | A-1235 |
Q102113472 | A-1336 |
Q102113476 | A-1617 |
Q54605968 | A-172 |
Q102113480 | A-2095 |
Q54605985 | A-253 |
Q54606033 | A-388 |
Q54606034 | A-427 |
Q102113490 | A-427F |
Q4649475 | A-549 |
Q54606055 | A-673 |
Q54606061 | A-704 |
Q54606065 | A-875 |
Q54795836 | BE |
Q54836006 | GM00054 |
Q54836363 | GM00637 |
Q54836364 | GM00638 |
Q54872126 | H4 |
Q28334700 | HT-29 |
Q847482 | HeLa |
Q54882556 | HeLa S3 |
Q102114151 | Hs 750.M |
Q54895991 | Hs 750.T |
Q54896930 | HuTu 80 |
Q54897669 | IMR-90 |
Q102114227 | IMR90-830 |
Q102114228 | IMR90-890 |
Q54994025 | WI-26 |
Q54994026 | WI-26 VA4 |
Q7950532 | WI-38 |
Q54994032 | WI-38 VA13 subline 2RA |
Q98135282 | XP12RO |
Q70232894 | A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA |
Q68197368 | A complex pattern of sensitivity to simple monofunctional alkylating agents exists amongst the rad mutants of Saccharomyces cerevisiae |
Q40535788 | A mechanism for deletion formation in DNA by human cell extracts: the involvement of short sequence repeats |
Q77932320 | Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone |
Q35825204 | Active site amino acid sequence of the bovine O6-methylguanine-DNA methyltransferase |
Q41851764 | Activity of a new nitrosourea (TCNU) in human lung cancer xenografts |
Q54429138 | Adaptation-like response to the chemical induction of sister chromatid exchanges in human lymphocytes. |
Q36309249 | Adaptive resynthesis of O6-methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair |
Q37683586 | Alkylating agent resistance: in vitro studies with human cell lines |
Q43169766 | Alkylation and Carbamylation Effects of Lomustine and Its Major Metabolites and MGMT Expression in Canine Cells |
Q41109937 | Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line |
Q71627385 | An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts |
Q73085497 | Analysis of O6-methylguanine-DNA methyltransferase mRNA in fine needle biopsies from human melanoma metastases by reverse transcription and polymerase chain reaction |
Q33451528 | Anti-tumour, toxicological and pharmacokinetic properties of a novel taurine-based nitrosourea (TCNU). |
Q73835486 | Anticancer drug resistance in primary human brain tumors |
Q41647414 | Assessment of antineoplastic agents by MTT assay: partial underestimation of antiproliferative properties |
Q41552527 | Ataxia telangiectasia: An investigation of the repair defect in the cell line AT5BIVA by plasmid reconstitution |
Q36291286 | Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents |
Q42808106 | Characterization and chemosensitivity of two cell lines derived from human glioblastomas |
Q35792879 | Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene |
Q38431462 | Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma. |
Q44019631 | Chromosomal response of human lymphocytes to streptozotocin |
Q40743157 | Chromosome aberrations induced in vitro: mechanisms, delayed expression, and intriguing questions |
Q41711752 | Cisplatin and CCNU synergism in spheroid cell subpopulations |
Q33880958 | Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene |
Q45033014 | Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas |
Q40494530 | Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase |
Q33527073 | Current data and strategy in glioblastoma multiforme |
Q36130099 | Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells |
Q43050485 | Cytotoxicity of 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MTIC) on Mer+, Mer+Rem- and Mer- cell lines: differential potentiation by 3-acetamidobenzamide |
Q41614931 | DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells |
Q41685430 | DNA damage induced by alkylating agents and repair pathways |
Q28279569 | DNA hypermethylation status of multiple genes in soft tissue sarcomas |
Q33699997 | DNA ligase IV as a new molecular target for temozolomide |
Q70160564 | DNA repair |
Q37949479 | DNA repair at the level of the gene: molecular and clinical considerations |
Q35531287 | DNA repair mechanisms in cancer development and therapy |
Q39849516 | DNA repair: relationship to drug and radiation resistance, metastasis and growth factors |
Q53569340 | Decreased host cell reactivation of UV-irradiated adenovirus 5 by fibroblasts from Cockayne's syndrome patients |
Q72766600 | Defective DNA endonuclease activity on anthramycin treated DNA in xeroderma pigmentosum and mouse melanoma cells |
Q68448475 | Deficient repair of O6-methylguanine in lymphocytes from rheumatoid arthritis families may be an acquired defect |
Q44182296 | Differential sensitivities to gamma radiation of human bladder and testicular tumour cell lines |
Q39104409 | Do carcinogen-modified deoxynucleotide precursors contribute to cellular mutagenesis? |
Q39684689 | Drug resistance and DNA repair |
Q40560888 | Drug resistance in brain tumors |
Q41447155 | Effects of thymidine kinase and methyltransferase deficiency on mutagenesis in human lymphoblastoid cell line |
Q39697091 | Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells |
Q34360262 | Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells |
Q46916399 | Evaluation of streptozotocin genotoxicity in rats from different ages using the micronucleus assay |
Q34670992 | Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA. |
Q41545350 | Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents |
Q36307032 | Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine |
Q34288659 | Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer |
Q41634016 | Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex- |
Q28216629 | Genotoxicity of streptozotocin |
Q34563690 | Host cell reactivation of gamma-irradiated adenovirus 5 in human cell lines of varying radiosensitivity |
Q45292967 | Host cell reactivation of sunlamp-exposed adenovirus in fibroblasts from patients with Bloom's syndrome, ataxia telangiectasia, and Huntington's disease |
Q53562926 | Human and rodent transformed cells are more sensitive to in vitro induction of SCE by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) than normal cells |
Q39457448 | Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma |
Q71827139 | Increased sensitivity of a xeroderma pigmentosum lymphoblastoid cell line to serum deprivation in vitro |
Q36732350 | Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments |
Q53553836 | Induction and repair of macromolecular damage by alkylating agents |
Q33602396 | Influence of alkyltransferase activity and chromosomal locus on mutational hotspots in Chinese hamster ovary cells |
Q37541006 | Inherently radioresistant cells exist in some human tumors |
Q73850206 | Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents |
Q48253063 | Intracarotid infusion of ACNU and BCNU as adjuvant therapy of malignant gliomas. Clinical aspects and critical considerations |
Q24336908 | Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine |
Q54199400 | MGMT gene silencing by promoter hypermethylation in gastric cancer in a high incidence area. |
Q51604204 | MGMT promoter methylation and immunoexpression in aggressive pituitary adenomas and carcinomas. |
Q36812588 | MGMT: a personal perspective |
Q28608973 | Mechanisms of human DNA repair: an update |
Q37508672 | Metabolism of the chloroethylnitrosoureas |
Q40023435 | Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene |
Q37861732 | Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools |
Q57285701 | MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP |
Q37060983 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli |
Q53443057 | Mutations of O6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China. |
Q36801155 | Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria |
Q72794484 | Nuclear DNA endonuclease activities on partially apurinic/apyrimidinic DNA in normal human and xeroderma pigmentosum lymphoblastoid and mouse melanoma cells |
Q72771354 | Nuclear deoxyribonuclease activities in normal and xeroderma pigmentosum lymphoblastoid cells |
Q58855440 | O 6-Methylguanine-DNA methyltransferase activity and induction of novel immunogenicity in murine tumor cells treated with methylating agents |
Q37686847 | O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea |
Q89497366 | O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy |
Q42371298 | O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines |
Q42590301 | O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours |
Q37527471 | Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair |
Q41891562 | Preclinical evaluation of an O(6)-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains |
Q40175495 | Predictive tests in cancer chemotherapy. A reappraisal |
Q54600804 | Promoter hypermethylation of DNA repair gene MGMT in laryngeal squamous cell carcinoma. |
Q40784270 | Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma |
Q37674355 | Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents |
Q48600793 | Radiosensitivity testing of human primary brain tumor specimens |
Q30486899 | Recessive mechanisms of malignancy |
Q32128152 | Reduction of BCNU toxicity to lung cells by high-level expression of O(6)-methylguanine-DNA methyltransferase |
Q37396587 | Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene |
Q39716063 | Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells |
Q36974306 | Regulation of the capacity for O6-methylguanine removal from DNA in human lymphoblastoid cells studied by cell hybridization |
Q36797925 | Regulation of the cell cycle following DNA damage in normal and Ataxia telangiectasia cells |
Q38309365 | Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300. |
Q44266680 | Relative repair of adenovirus damaged by sunlamp, UV and gamma-irradiation in Cockayne syndrome fibroblasts is different from that in xeroderma pigmentosum fibroblasts |
Q36309534 | Removal of O6-methylguanine from DNA by human liver fractions |
Q41558547 | Repair and misrepair of site-specific DNA double-strand breaks by human cell extracts |
Q39838806 | Repair of DNA alkylation adducts in mammalian cells |
Q35035775 | Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas |
Q33926831 | Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea |
Q39114338 | Replication across O6-methylguanine by human DNA polymerase beta in vitro. Insights into the futile cytotoxic repair and mutagenesis of O6-methylguanine |
Q39109388 | Replication and demethylation of O6-methylguanine in DNA. |
Q71246010 | Replication of O6-methylguanine-containing DNA by repair and replicative DNA polymerases |
Q41518857 | Response of radiation-sensitive human cells to defined DNA breaks |
Q68029114 | Sister chromatid exchange frequency, cellular replication and relative cloning efficiency in human teratocarcinoma-derived cells |
Q41329417 | Streptozotocin-induced genotoxic effects in Chinese hamster cells: The resistant phenotype of V79 cells |
Q41399286 | Streptozotocin‐induced toxicity in CHO‐9 and V79 cells |
Q35967782 | Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts |
Q37392653 | Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes |
Q39672704 | The 1987 Walter Hubert lecture. Regulation and deficiencies in DNA repair |
Q46280203 | The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells |
Q35992318 | The effects of pretreatment of human tumour cells with MNNG on the DNA crosslinking and cytotoxicity of mitozolomide |
Q28741768 | The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma |
Q40136421 | The initiation of DNA excision-repair. |
Q40525439 | The rejoining of double-strand breaks in DNA by human cell extracts |
Q41193565 | The role of DNA repair in the prevention of cancer |
Q77753619 | The sensitization of cells treated with O6-methylguanine to alkylation damage is affected by the number of O6-methylguanine-DNA methyltransferase molecules escaped from inactivation |
Q27936976 | TheSaccharomyces cerevisiae MGT1DNA repair methyltransferease gene: its promoter and entire coding sequence, regulation andin vivobiological functions |
Q40659434 | Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells |
Q50089369 | Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas |
Q41693152 | UV mutation spectra in cell lines from patients with Cockayne's syndrome and ataxia telangiectasia, using the shuttle vector pZ189 |
Q30428760 | Understanding and manipulating O6-methylguanine-DNA methyltransferase expression |
Q33892805 | Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents |
Q53514870 | Use of cell cultures for predicting the biological effects of mycotoxins. |
Q45798750 | Virus-induced gene mutations of eukaryotic cells |
Q35387486 | p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis |
Q42925815 | p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor |