| P2093 | author name string | Eileen Dolan M | |
| P2860 | cites work | Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine | Q24336908 |
| | Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856) | Q24683819 |
| | Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer | Q33362161 |
| | Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study | Q33477348 |
| | Isolation and cDNA cloning of a rat O6-alkylguanine-DNA-alkyltransferase gene, molecular analysis of expression in rat liver | Q33529425 |
| | Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent | Q33609622 |
| | Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents | Q33689518 |
| | O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells | Q34568108 |
| | Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation | Q35171306 |
| | Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea | Q35943817 |
| | Systemic chemotherapy for malignant melanoma | Q35993154 |
| | Formation of covalent complexes between human O6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides | Q36058843 |
| | O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis | Q36414865 |
| | Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors | Q37476708 |
| | Metabolism of the chloroethylnitrosoureas | Q37508672 |
| | Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair | Q37527471 |
| | Site-specific mutagenesis: retrospective and prospective | Q37742244 |
| | Nitrosoureas from chemist to physician: classification and recent approaches to drug design | Q37854235 |
| | DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal | Q37984292 |
| | Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine | Q38314205 |
| | Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy. | Q39570460 |
| | Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme | Q39844025 |
| | Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase | Q40494530 |
| | DNA-repair methyltransferase as a molecular device for preventing mutation and cancer | Q40970560 |
| | The secondary leukemias: challenges and research directions | Q40980598 |
| | Incidence of second cancers in patients treated for Hodgkin's disease | Q40985408 |
| | Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents | Q41199462 |
| | Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo | Q41428069 |
| | Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells | Q41548366 |
| | Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone | Q41577842 |
| | Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea | Q41653597 |
| | The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA. | Q41666185 |
| | A polymorphism at codon 160 of human O6 methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay | Q41671919 |
| | Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique | Q41749242 |
| | Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine | Q42046696 |
| | Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli | Q42225259 |
| | Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours | Q42488879 |
| | Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine | Q42494150 |
| | The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells | Q46280203 |
| | Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. | Q48379404 |
| | Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues | Q48708608 |
| | Targeting of O6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide. | Q53458876 |
| | 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase. | Q53466577 |
| | Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro. | Q53480469 |
| | Cell type-specific expression of the O6-alkylguanine-DNA alkyltransferase gene in normal human liver tissues as revealed by in situ hybridization. | Q53481050 |
| | Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase | Q53486098 |
| | Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine | Q53495189 |
| | O6-methylguanine-DNA methyltransferase activity in human liver tumors. | Q53497467 |
| | Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone. | Q53561222 |
| | Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase. | Q54186447 |
| | Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). | Q54235482 |
| | Activity and unexpected lung toxicity of the sequential administration of two alkylating agents--dacarbazine and fotemustine--in patients with melanoma. | Q54250630 |
| | Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. | Q54255608 |
| | O6-methylguanine-DNA methyltransferase activity in breast and brain tumors. | Q55480784 |
| | Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines. | Q55481088 |
| | Metabolism and Disposition of O6-Benzyl-2'-deoxyguanosine in Sprague-Dawley Rats | Q55481654 |
| | Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. | Q55484775 |
| | Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains | Q59085307 |
| | Expression of O6-alkylguanine-DNA-alkyltransferase in situ in ovarian and Hodgkin's tumours | Q59305095 |
| | Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine | Q67975150 |
| | Measurement of O6-methylguanine-type adducts in DNA and O6-alkylguanine-DNA-alkyltransferase repair activity in normal and neoplastic human tissues | Q68010893 |
| | Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells | Q69061183 |
| | Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells | Q69319935 |
| | The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase | Q70533182 |
| | Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea | Q70633236 |
| | Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer | Q70733027 |
| | Human liver oxidative metabolism of O6-benzylguanine | Q71598935 |
| | Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers | Q72037759 |
| | Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase | Q72067168 |
| | Smoking-related increase in O6-alkylguanine-DNA alkyltransferase activity in human lung tissue | Q72118384 |
| | Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells | Q72165376 |
| | Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase | Q72774928 |
| | Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents | Q93644067 |
| P433 | issue | 2-3 | |
| P304 | page(s) | 105-118 | |
| P577 | publication date | 1997-07-01 | |
| P1433 | published in | Advanced Drug Delivery Reviews | Q2825362 |
| P1476 | title | Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents | |
| P478 | volume | 26 | |