Molecular genetic analysis of circadian timekeeping in Drosophila

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Molecular genetic analysis of circadian timekeeping in Drosophila is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/B978-0-12-387690-4.00005-2
P932PMC publication ID4108082
P698PubMed publication ID21924977

P50authorPaul E. HardinQ52595274
P2860cites workCryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigationQ21092746
Activating PER repressor through a DBT-directed phosphorylation switchQ21145851
Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in DrosophilaQ21562193
Clock Mutants of Drosophila melanogasterQ22337192
PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcriptionQ24548191
Circadian rhythms persist without transcription in a eukaryoteQ24620683
Circadian clocks in human red blood cellsQ24620753
DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in DrosophilaQ24629055
Interlocked feedback loops contribute to the robustness of the Neurospora circadian clockQ24629961
Circadian organization of behavior and physiology in DrosophilaQ24633391
A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogasterQ24646091
DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clockQ24647875
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)Q24673354
Advanced analysis of a cryptochrome mutation's effects on the robustness and phase of molecular cycles in isolated peripheral tissues of DrosophilaQ24806604
Control of daily transcript oscillations in Drosophila by light and the circadian clockQ25257879
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.Q27863659
Posttranslational mechanisms regulate the mammalian circadian clockQ27863710
Light-dependent sequestration of TIMELESS by CRYPTOCHROMEQ28140397
Time zones: a comparative genetics of circadian clocksQ28215112
A role for casein kinase 2alpha in the Drosophila circadian clockQ28215935
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillatorQ28216502
Positional cloning of the mouse circadian clock geneQ28238809
The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activityQ28242110
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timelessQ28250580
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behaviorQ28252722
Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythmsQ28268460
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timelessQ28273955
A light-entrainment mechanism for the Drosophila circadian clockQ28276020
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulationQ28277205
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase IepsilonQ28277215
Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERLQ28284155
Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual systemQ28291602
Molecular bases for circadian clocksQ28297151
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levelsQ28297806
Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitroQ28485571
Circadian rhythms from multiple oscillators: lessons from diverse organismsQ28751778
Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behaviorQ28752390
Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in DrosophilaQ35968254
No promoter left behind: global circadian gene expression in cyanobacteriaQ36201629
The circadian timekeeping system of Drosophila.Q36247605
Molecular genetics of a biological clock in DrosophilaQ36266764
Circadian rhythms of superhelical status of DNA in cyanobacteriaQ36277040
Probing the relative importance of molecular oscillations in the circadian clockQ36515720
Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase CQ36604178
Essential and expendable features of the circadian timekeeping mechanism.Q36608234
Circadian oscillators of Drosophila and mammals.Q36665957
Spike amplitude of single-unit responses in antennal sensillae is controlled by the Drosophila circadian clockQ36776101
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Q36802821
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brainQ37000911
Natural variation in the splice site strength of a clock gene and species-specific thermal adaptation.Q37074048
The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resettingQ37111543
Synchronization of the Drosophila circadian clock by temperature cycles.Q37141013
Thermosensitive splicing of a clock gene and seasonal adaptationQ37141122
Genome-wide identification of targets of the drosha-pasha/DGCR8 complexQ37142093
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcriptionQ37233438
A plastic clock: how circadian rhythms respond to environmental cues in DrosophilaQ37254350
Splicing of the period gene 3'-terminal intron is regulated by light, circadian clock factors, and phospholipase C.Q37278053
Circadian oscillations in period gene mRNA levels are transcriptionally regulatedQ37336176
Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timelessQ37621646
Constitutive overexpression of the Drosophila period protein inhibits period mRNA cyclingQ37635108
Physiology of circadian entrainmentQ37776089
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screenQ38947942
PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcriptionQ39446565
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.Q40586727
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.Q40688638
Microarray analysis and organization of circadian gene expression in DrosophilaQ40765258
Large ventral lateral neurons modulate arousal and sleep in Drosophila.Q41141838
The blue-light photoreceptor CRYPTOCHROME is expressed in a subset of circadian oscillator neurons in the Drosophila CNS.Q42111441
PDP1epsilon functions downstream of the circadian oscillator to mediate behavioral rhythmsQ42233335
An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillatorQ42576895
NEMO kinase contributes to core period determination by slowing the pace of the Drosophila circadian oscillatorQ42729851
A subset of dorsal neurons modulates circadian behavior and light responses in DrosophilaQ42851948
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior.Q44422639
A constitutively active cryptochrome in Drosophila melanogaster.Q44982513
The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.Q45410799
Serotonin modulates circadian entrainment in DrosophilaQ46582313
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loopQ29616207
The mammalian circadian timing system: organization and coordination of central and peripheral clocksQ29619119
Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by lightQ30051192
Integration of light and temperature in the regulation of circadian gene expression in DrosophilaQ30445098
Nocturnal male sex drive in DrosophilaQ30481267
G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila.Q30489237
Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genesQ33305004
Circadian regulation of a limited set of conserved microRNAs in DrosophilaQ33320345
Circadian transcription contributes to core period determination in DrosophilaQ33336761
CLOCK expression identifies developing circadian oscillator neurons in the brains of Drosophila embryosQ33394403
The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in DrosophilaQ33587778
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA.Q33631146
The circadian output gene takeout is regulated by Pdp1epsilonQ33664186
Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulatorsQ33781149
A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradationQ33815603
Cycling vrille expression is required for a functional Drosophila clockQ33884903
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in DrosophilaQ33885458
Drosophila CRY is a deep brain circadian photoreceptorQ33904390
The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of KitQ33970274
The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factorsQ33970488
Photic signaling by cryptochrome in the Drosophila circadian systemQ34012628
Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogasterQ34036109
Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock.Q34082503
Circadian regulation of gene expression systems in the Drosophila headQ34102817
VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillatorQ34172689
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clockQ34176690
A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks.Q34213033
Restoration of circadian behavioural rhythms by gene transfer in DrosophilaQ34260514
Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in DrosophilaQ34313508
Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreceptionQ34324737
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptorQ34344222
Coupled oscillators control morning and evening locomotor behaviour of DrosophilaQ34358746
Morning and evening peaks of activity rely on different clock neurons of the Drosophila brainQ34358753
Reciprocal behaviour associated with altered homeostasis and photosensitivity of Drosophila clock mutantsQ34430924
Independent photoreceptive circadian clocks throughout DrosophilaQ34446958
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.Q34470738
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timelessQ34472115
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivityQ34482717
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila.Q34482723
Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shiftsQ34510198
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.Q34541185
Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clockQ34577048
Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogasterQ34593348
Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK proteinQ34597319
Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocksQ34605260
Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker componentQ34639250
A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clockQ34639260
The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline developmentQ34645410
Circadian rhythms in gene transcription imparted by chromosome compaction in the cyanobacterium Synechococcus elongatusQ34694533
Central and peripheral circadian oscillator mechanisms in flies and mammals.Q34770122
The novel gene twenty-four defines a critical translational step in the Drosophila clock.Q34776644
How a cyanobacterium tells timeQ34872329
Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless.Q34934505
Temporal phosphorylation of the Drosophila period proteinQ35103243
The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behaviorQ35805108
Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2.Q35935956
Transcription regulation within the circadian clock: the E-box and beyond.Q35943675
A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock functionQ35948140
In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD.Q46828876
The F-box protein slimb controls the levels of clock proteins period and timelessQ47070034
A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clockQ47070465
A new role for cryptochrome in a Drosophila circadian oscillator.Q47070472
The Drosophila circadian network is a seasonal timerQ47071292
A role for CK2 in the Drosophila circadian oscillatorQ47071691
Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neuronsQ47071963
Drosophila CRYPTOCHROME is a circadian transcriptional repressorQ47072854
A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous systemQ48162052
Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogasterQ48372567
Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocksQ48848396
The circadian clock of fruit flies is blind after elimination of all known photoreceptorsQ48886791
Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complexQ49053916
Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clockQ49053942
Resetting the circadian clock by social experience in Drosophila melanogaster.Q52111480
New short period mutations of the Drosophila clock gene per.Q52443317
The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function.Q52444248
Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock.Q52452000
P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic drosophila melanogasterQ52514536
Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Q52535865
Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock.Q52540550
PAS is a dimerization domain common to Drosophila period and several transcription factors.Q52545395
Molecular, biochemical, and electrophysiological characterization of Drosophila norpA mutants.Q52547535
Natural variation in a Drosophila clock gene and temperature compensation.Q52560702
The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex.Q52566479
Circadian rhythms in olfactory responses of Drosophila melanogaster.Q52571996
A role for the proteasome in the light response of the timeless clock protein.Q52572922
How a circadian clock adapts to seasonal decreases in temperature and day length.Q52576490
A unique circadian-rhythm photoreceptor.Q52578128
Genome-wide transcriptional orchestration of circadian rhythms in Drosophila.Q52594413
Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity.Q52595230
Social experience modifies pheromone expression and mating behavior in male Drosophila melanogaster.Q52693559
PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila.Q52699389
Circadian biology: environmental regulation of a multi-oscillator network.Q52704321
Interlocked Feedback Loops Within the Drosophila Circadian OscillatorQ58027719
An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian systemQ72292295
dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complexQ73469642
Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projectionsQ73863915
Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in DrosophilaQ79975360
P921main subjectcircadian rhythmQ208353
DrosophilaQ312154
P304page(s)141-173
P577publication date2011-01-01
P1433published inAdvances in GeneticsQ26842228
P1476titleMolecular genetic analysis of circadian timekeeping in Drosophila
P478volume74

Reverse relations

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