CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication

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CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E05-05-0412
P932PMC publication ID1237101
P698PubMed publication ID16093348

P2093author name stringJoachim J Li
Van Q Nguyen
Kaoru Irie
Muluye E Liku
Audrey W Rosales
P2860cites workHuman CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phaseQ24310880
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingQ24313280
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisQ24515107
Disruption of mechanisms that prevent rereplication triggers a DNA damage responseQ24529993
The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeastQ24532802
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationQ24533531
Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structuresQ24545600
Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageQ24558657
Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpointQ24563819
Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localizationQ24617490
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6Q24656841
Loss of Geminin induces rereplication in the presence of functional p53Q24676493
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionQ24685870
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Uninterrupted MCM2-7 function required for DNA replication fork progressionQ27929772
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.Q27932153
A group of interacting yeast DNA replication genesQ27932669
Characterization of karyopherin cargoes reveals unique mechanisms of Kap121p-mediated nuclear importQ27934921
G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleusQ27937350
A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiaeQ27938381
Roles of phosphorylation sites in regulating activity of the transcription factor Pho4.Q27938391
The bipartite nuclear localization sequence of Rpn2 is required for nuclear import of proteasomal base complexes via karyopherin alphabeta and proteasome functionsQ27939320
Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.Q27939332
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replicationQ27939757
Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6Q27939995
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
DNA replication in eukaryotic cellsQ28131747
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanismsQ28204020
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradationQ28248715
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expressionQ28250231
Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phaseQ28354208
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
Targets of the cyclin-dependent kinase Cdk1Q29616479
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycleQ29619289
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.Q30312052
Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.Q33775448
Regulation of nuclear localization: a key to a doorQ33804320
Nuclear targeting signal recognition: a key control point in nuclear transport?Q33936678
Multiple mechanisms regulate subcellular localization of human CDC6.Q33946248
Control of DNA replication and chromosome ploidy by geminin and cyclin AQ34323837
Regulation of early events in chromosome replicationQ34349937
Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycleQ35204963
Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiaeQ35917356
The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replicationQ36731987
Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assemblyQ36951274
Spc98p directs the yeast gamma-tubulin complex into the nucleus and is subject to cell cycle-dependent phosphorylation on the nuclear side of the spindle pole bodyQ38611058
MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpointQ39231854
The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence.Q40482485
Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase.Q40487864
Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.Q40789015
The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiaeQ42676980
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.Q46384443
Regulation of nuclear import by phosphorylation adjacent to nuclear localization signalsQ48004807
Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits.Q48098747
Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.Q52087804
Cellular substrates of p34cdc2 and its companion cyclin-dependent kinasesQ57985194
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication controlQ59098617
Nuclear accumulation of Saccharomyces cerevisiae Mcm3 is dependent on its nuclear localization sequenceQ62950086
Biochemical function of mouse minichromosome maintenance 2 proteinQ74392968
P433issue10
P921main subjectphosphorylationQ242736
P304page(s)5026-5039
P577publication date2005-08-10
P1433published inMolecular Biology of the CellQ2338259
P1476titleCDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication
P478volume16

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