Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase.

scientific article

Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.78.24.13954-13965.2004
P932PMC publication ID533924
P698PubMed publication ID15564503
P5875ResearchGate publication ID8161989

P50authorJeffrey W. HarperQ57326226
P2093author name stringWentao Deng
Crystal G Wheeler
Louise T Chow
Thomas R Broker
Biing Yuan Lin
Ge Jin
Tianlin Ma
P2860cites workIdentification of domains of the HPV11 E1 protein required for DNA replication in vitroQ22254364
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationQ24533531
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6Q24656841
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionQ24685870
The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA bindingQ27642462
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitineQ27734755
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleusQ27937350
Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeastQ27937775
Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.Q27939332
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.Q27940280
MCM proteins in DNA replicationQ27976474
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
DNA replication in eukaryotic cellsQ28131747
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2Q28140699
Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sitesQ28142808
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesisQ28143403
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanismsQ28204020
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expressionQ28250231
Nuclear export receptors: from importin to exportinQ28250554
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1Q28613275
Identification of a signal for rapid export of proteins from the nucleusQ29547742
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycleQ29619289
The specificities of protein kinase inhibitors: an updateQ30014834
Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeastQ30032023
The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicaseQ30420704
Recruitment of replication protein A by the papillomavirus E1 protein and modulation by single-stranded DNAQ31038703
Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral originsQ33611284
Substrate targeting in the ubiquitin systemQ33641408
Four-dimensional control of the cell cycleQ33772655
Characterization of the DNA-binding domain of the bovine papillomavirus replication initiator E1.Q33782934
The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activitiesQ33783679
A C-terminal helicase domain of the human papillomavirus E1 protein binds E2 and the DNA polymerase alpha-primase p68 subunit.Q33783875
Nuclear targeting signal recognition: a key control point in nuclear transport?Q33936678
Regulation of the G2/M transition by p53.Q33943437
Multiple mechanisms regulate subcellular localization of human CDC6.Q33946248
Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activityQ34084017
New perspectives on nuclear transportQ34432243
Control of DNA replication licensing in a cell cycleQ34523944
Replication licensing--defining the proliferative state?Q34534992
Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replicationQ34809313
Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycleQ35204963
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseasesQ35680797
Bovine papillomavirus E1 protein binds specifically DNA polymerase alpha but not replication protein AQ35837716
Chromotin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replicationQ35845271
Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading framesQ35921639
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replicationQ36068854
Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.Q36203922
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicaseQ36336279
Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assayQ36561338
Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complexQ37230712
Complexes of polyoma virus medium T antigen and cellular proteinsQ37537980
Monoclonal antibodies to mitotic cellsQ37611790
Characterization of recombinant HPV6 and 11 E1 helicases: effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain.Q38301958
Genetically defined nuclear localization signal sequence of bovine papillomavirus E1 protein is necessary and sufficient for the nuclear localization of E1-beta-galactosidase fusion proteinsQ38304608
Biochemical and electron microscopic image analysis of the hexameric E1 helicase.Q38328578
Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complexQ39452917
Functional interaction between the bovine papillomavirus virus type 1 replicative helicase E1 and cyclin E-Cdk2.Q39580168
The hinge of the human papillomavirus type 11 E2 protein contains major determinants for nuclear localization and nuclear matrix associationQ39590559
The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycleQ39592146
Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 proteinQ39681443
Characterization of the minimal DNA binding domain of the human papillomavirus e1 helicase: fluorescence anisotropy studies and characterization of a dimerization-defective mutant proteinQ39748610
mRNA splicing regulates human papillomavirus type 11 E1 protein production and DNA replicationQ40008754
The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.Q40044355
Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteinsQ40309052
E1 protein of human papillomavirus is a DNA helicase/ATPaseQ40412036
The E2 binding sites determine the efficiency of replication for the origin of human papillomavirus type 18Q40535614
Human papillomavirus DNA replication. Interactions between the viral E1 protein and two subunits of human dna polymerase alpha/primaseQ40978893
Active domains of human papillomavirus type 11 E1 protein for origin replicationQ41021951
Regulation of protein transport to the nucleus: central role of phosphorylationQ41075705
Modulation of bovine papillomavirus DNA replication by phosphorylation of the viral E1 proteinQ41128663
The Functions of Human Papillomavirus Type 11 E1, E2, and E2C Proteins in Cell-free DNA ReplicationQ41271576
Cell-free replication of the human papillomavirus DNA with homologous viral E1 and E2 proteins and human cell extractsQ41441440
Nuclear export of proteins and RNAsQ41477073
Activation of BPV-1 replication in vitro by the transcription factor E2.Q43594856
Human Hsp70 and Hsp40 chaperone proteins facilitate human papillomavirus-11 E1 protein binding to the origin and stimulate cell-free DNA replicationQ44770612
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.Q48965240
Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytesQ57373971
SUMO-1 modification of bovine papillomavirus E1 protein is required for intranuclear accumulationQ73004209
HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replicationQ73487322
Contribution of bovine papillomavirus type 1 E1 protein residue 48 to replication functionQ74016229
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)13954-13965
P577publication date2004-12-01
P1433published inJournal of VirologyQ1251128
P1476titleCyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase
P478volume78

Reverse relations

cites work (P2860)
Q34982704A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication
Q61774978A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK-cyclin complexes and G2/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L
Q42116313A phosphorylation map of the bovine papillomavirus E1 helicase
Q92039755Activity of CK2α protein kinase is required for efficient replication of some HPV types
Q34215453Attributes of short linear motifs.
Q34049869CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication
Q36978987CK2 phosphorylation inactivates DNA binding by the papillomavirus E1 and E2 proteins.
Q52838421Cellular Model of p21-Induced Senescence.
Q35158114Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication
Q34647386Different modes of human papillomavirus DNA replication during maintenance
Q36559588Engagement of the ATR-dependent DNA damage response at the human papillomavirus 18 replication centers during the initial amplification
Q40304397HPV16 E1--E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm
Q39013547Host cell restriction factors that limit transcription and replication of human papillomavirus.
Q36424104Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes
Q36938528Human papillomavirus infections: warts or cancer?
Q37257349Human papillomavirus molecular biology and disease association
Q36537688Identification of a nuclear export signal sequence for bovine papillomavirus E1 protein
Q34479115Impact of HPV in Oropharyngeal Cancer
Q35826814Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide
Q24314673Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1
Q41669449Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes
Q40162029Mitogen-activated protein kinases activate the nuclear localization sequence of human papillomavirus type 11 E1 DNA helicase to promote efficient nuclear import
Q33584852Molecular characterization, tissue tropism, and genetic variability of the novel Mupapillomavirus type HPV204 and phylogenetically related types HPV1 and HPV63.
Q28740849Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response
Q34295899Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance
Q42957423Nucleocytoplasmic shuttling of bovine papillomavirus E1 helicase downregulates viral DNA replication in S phase
Q37367646Papillomavirus DNA replication - from initiation to genomic instability
Q40244150Phosphorylation of bovine papillomavirus E1 by the protein kinase CK2 near the nuclear localization signal does not influence subcellular distribution of the protein in dividing cells.
Q37145237Phosphorylation of the human papillomavirus type 16 E1--E4 protein at T57 by ERK triggers a structural change that enhances keratin binding and protein stability
Q36284493Recent advances in the search for antiviral agents against human papillomaviruses.
Q37870408Regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis?
Q35150925Replication and partitioning of papillomavirus genomes
Q37522596Replication interference between human papillomavirus types 16 and 18 mediated by heterologous E1 helicases.
Q35107717Small molecule inhibitors of human papillomavirus protein - protein interactions
Q36262707Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus
Q36315302Targeting human papillomavirus genome replication for antiviral drug discovery
Q37262962The E1 proteins
Q42271216The E4 protein; structure, function and patterns of expression
Q38064068The biology and life-cycle of human papillomaviruses.
Q28740852The papillomavirus E1 helicase activates a cellular DNA damage response in viral replication foci

Search more.