Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma

scientific article

Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CCR.2014.06.005
P932PMC publication ID4143139
P698PubMed publication ID25117714

P50authorMarkus RiesterQ41050073
Massimo SquatritoQ55459211
Eric C HollandQ89747805
Franziska MichorQ33177805
P2093author name stringJason T Huse
Tatsuya Ozawa
Nikki Charles
Karim Helmy
Yu-Kang Cheng
P2860cites workBioconductor: open software development for computational biology and bioinformaticsQ21194861
Mechanism of action and in vivo role of platelet-derived growth factorQ22010594
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Identification of a CpG island methylator phenotype that defines a distinct subgroup of gliomaQ24612429
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
The 2007 WHO classification of tumours of the central nervous systemQ24685772
The neighbor-joining method: a new method for reconstructing phylogenetic treesQ25939010
Genetic instabilities in human cancersQ28131826
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effectsQ28511432
lumi: a pipeline for processing Illumina microarrayQ29614924
Role of platelet-derived growth factors in physiology and medicineQ29615222
Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma modelQ38335045
Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB).Q38468748
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastomaQ40407116
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in miceQ40881142
Modeling Adult Gliomas Using RCAS/t-va TechnologyQ41843698
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastomaQ42013793
Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesisQ42827324
Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaningQ43598274
Generation of RCAS vectors useful for functional genomic analyses.Q43826373
PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signalingQ46365844
PTEN methylation and expression in glioblastomasQ48232099
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.Q52008070
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterationsQ30885944
Aneuploidy and confined chromosomal mosaicism in the developing human brain.Q33288955
The transcriptional network for mesenchymal transformation of brain tumours.Q33572162
A differentiation-based phylogeny of cancer subtypesQ33576721
Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulationQ33656940
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiationQ33733341
Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells.Q33872283
Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progressionQ33960280
A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesisQ34126248
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomasQ34164924
A mathematical framework to determine the temporal sequence of somatic genetic events in cancerQ34200279
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytomaQ34509145
Chronic myeloid leukaemiaQ34657509
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivoQ35080265
Mosaic analysis with double markers reveals tumor cell of origin in gliomaQ35127020
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in miceQ35211546
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in miceQ35801259
Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.Q36269892
Identification of global alteration of translational regulation in glioma in vivoQ36295318
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivoQ36453531
Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in gliomaQ36528386
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Q36673354
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in miceQ36677747
The genomically mosaic brain: aneuploidy and more in neural diversity and diseaseQ36799509
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesisQ37115208
Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.Q37279893
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomasQ37281335
Pten haploinsufficiency accelerates formation of high-grade astrocytomasQ37384874
The definition of primary and secondary glioblastomaQ38064831
P433issue2
P921main subjectglioblastomaQ282142
P304page(s)288-300
P577publication date2014-08-01
P1433published inCancer CellQ280018
P1476titleMost human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma
P478volume26

Reverse relations

cites work (P2860)
Q89291590A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB
Q58799676A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
Q44457966A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics
Q96348394A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
Q88701275A new method of identifying glioblastoma subtypes and creation of corresponding animal models
Q89724165A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level
Q33761660A peptide derived from apoptin inhibits glioma growth
Q98154728A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures
Q37269034ABCG1 maintains high-grade glioma survival in vitro and in vivo.
Q64068988ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Q48446221ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma
Q57296293Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival
Q38364234Advances and challenges in the molecular biology and treatment of glioblastoma-is there any hope for the future?
Q40974703Angiogenic Gene Signature Derived from Subtype Specific Cell Models Segregate Proneural and Mesenchymal Glioblastoma
Q55456769Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors.
Q38858314Applications of the CRISPR/Cas9 system in murine cancer modeling
Q66679168Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma
Q38839352Association between tumor architecture derived from generalized Q-space MRI and survival in glioblastoma
Q90058737Astrocytes enhance glioblastoma growth
Q47304287Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastomas
Q48228839Brain Tumor Stem Cells Remain in Play
Q97542930Brain tumors in Neurofibromatosis type 1
Q55351090CDK4/6 and PDGFRA Signaling as Therapeutic Targets in Diffuse Intrinsic Pontine Glioma.
Q55010335CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.
Q26781783Cancer classification in the genomic era: five contemporary problems
Q93260327Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis
Q35128022Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma
Q63151952Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma
Q90365564Circulating tumor cells and their advances to promote cancer metastasis and relapse, with focus on glioblastoma multiforme
Q59333163Clinical evaluation of a dedicated next generation sequencing panel for routine glioma diagnostics
Q35573268Coexpression analysis of CD133 and CD44 identifies proneural and mesenchymal subtypes of glioblastoma multiforme.
Q34513800Collateral Lethality: A new therapeutic strategy in oncology
Q33777905Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas
Q33786677Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity.
Q37649442Cooperative genomic alteration network reveals molecular classification across 12 major cancer types
Q47851037Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma.
Q42366669Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?
Q30276928Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells
Q38677899Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence
Q54153689Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression.
Q55456904Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma.
Q61794394Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
Q42228181Double minute amplification of mutant PDGF receptor α in a mouse glioma model
Q37269061Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis.
Q48014727EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
Q55080493ERBB3, IGF1R, and TGFBR2 expression correlate with PDGFR expression in glioblastoma and participate in PDGFR inhibitor resistance of glioblastoma cells.
Q90429073Elevation of CXCL1 indicates poor prognosis and radioresistance by inducing mesenchymal transition in glioblastoma
Q47154528Engineering PTEN-L for Cell-Mediated Delivery.
Q42529862EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells
Q50100856Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
Q46890724Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression.
Q37217995Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model
Q64230366Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes
Q64880162Expression of GLUT1 in Pseudopalisaded and Perivascular Tumor Cells Is an Independent Prognostic Factor for Patients With Glioblastomas.
Q30275293Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis
Q47970311Frozen tissue preparation for high-resolution multiplex histological analyses of human brain specimens
Q47912595Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.
Q97433113Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade
Q36328555Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.
Q26823823Glioblastoma Circulating Cells: Reality, Trap or Illusion?
Q64056689Glioblastoma Stem- Cells, Metabolic Strategy to Kill a Challenging Target
Q47097367Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Q38460865Glioblastoma: pathology, molecular mechanisms and markers
Q100454881Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Q46820292Glioma.
Q38366332Glycosylation alterations in lung and brain cancer
Q41824050HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss
Q45870735Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas
Q27013006Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma
Q33646231High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients.
Q36379857Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesis
Q92353570IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
Q97543429Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity
Q47915209Immunotherapies for malignant glioma.
Q92013024Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma
Q38618205Implications of mitogen-activated protein kinase signaling in glioma.
Q36299611In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma
Q52597914Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.
Q42101562Induction of senescence in primary glioblastoma cells by serum and TGFβ.
Q38737715Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma.
Q47756210Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis
Q92666770LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
Q58730941Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
Q41101267Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells.
Q93012197Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
Q36232178Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma
Q49390262Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
Q33744534Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
Q57116103Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway
Q49639816MethCNA: a database for integrating genomic and epigenomic data in human cancer
Q58121730Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
Q91966182Modeling Gliomas Using Two Recombinases
Q38453759Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Q48010499Molecular and clinical heterogeneity of adult diffuse low-grade IDH wild-type gliomas: assessment of TERT promoter mutation and chromosome 7 and 10 copy number status allows superior prognostic stratification
Q47738114Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data
Q97072841Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma
Q97653033Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
Q55457207Mutant IDH1 Promotes Glioma Formation In Vivo.
Q42259199Mutant IDH1 regulates the tumor-associated immune system in gliomas
Q58779206NF-κB, Mesenchymal Differentiation and Glioblastoma
Q48018806Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma.
Q58576103Next-Generation Modeling of Human Cancers
Q37301799Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma
Q37097023Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma
Q55456695Oligosaccharyltransferase inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity.
Q45916518Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.
Q64975191Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Q47109987PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT.
Q55457210PI3K Activation in Neural Stem Cells Drives Tumorigenesis which can be Ameliorated by Targeting the cAMP Response Element Binding (CREB) Protein.
Q37702754PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion
Q92987374Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness
Q37240846Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial
Q36803476Pediatric gliomas as neurodevelopmental disorders
Q64946837Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation.
Q38262433Platelet-derived growth factor in glioblastoma-driver or biomarker?
Q39223541Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.
Q36200482Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes
Q41718329Predicting clinical outcomes from large scale cancer genomic profiles with deep survival models
Q50026526Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages.
Q90376867Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2
Q35376154Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.
Q47583690Prognostic relevance of genetic alterations in diffuse lower-grade gliomas
Q92544093Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma
Q48167510Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion
Q38732473Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture
Q92089518Quantitative proteomics reveals reduction of endocytic machinery components in gliomas
Q35306157Radiological and pathological features associated with IDH1-R132H mutation status and early mortality in newly diagnosed anaplastic astrocytic tumours
Q52608306Reconstructing the molecular life history of gliomas.
Q52668450Revisit the Candidacy of Brain Cell Types as the Cell(s) of Origin for Human High-Grade Glioma.
Q47829797Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.
Q42572216Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation
Q38927317Spatiotemporal genomic architecture informs precision oncology in glioblastoma
Q52724352Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.
Q43494911Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Q92702657The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas
Q89686775The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically
Q89587165The Sociobiology of Brain Tumors
Q48532756The angiogenic switch leads to a metabolic shift in human glioblastoma
Q39132571The evolution of tumour phylogenetics: principles and practice
Q64101370The landscape of the mesenchymal signature in brain tumours
Q90412264The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1
Q33744491The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
Q46410671Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Q47104172Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.
Q57040018Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma
Q36250650pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma

Search more.