| scholarly article | Q13442814 |
| P50 | author | Gregory T Robbins | Q82072874 |
| Yong Tang | Q124331534 | ||
| Yakun Chen | Q124331544 | ||
| Daotai Nie | Q124331546 | ||
| P2860 | cites work | Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction | Q24646162 |
| The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity | Q27632611 | ||
| Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism | Q27641100 | ||
| The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux | Q28186424 | ||
| The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4 | Q28201907 | ||
| Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin | Q28211706 | ||
| Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR | Q28212465 | ||
| An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway | Q28263744 | ||
| Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response | Q29616508 | ||
| Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure | Q33495882 | ||
| Cytochrome P-450 3A4: regulation and role in drug metabolism | Q33636632 | ||
| The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor | Q33642959 | ||
| Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). | Q33781766 | ||
| Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers | Q33881813 | ||
| A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway | Q33945905 | ||
| The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha | Q33968352 | ||
| Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy? | Q34413170 | ||
| Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor | Q34563453 | ||
| Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. | Q36068699 | ||
| Regulation of drug resistance by human pregnane X receptor in breast cancer | Q36083299 | ||
| Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism | Q36097229 | ||
| Pregnane X receptor and its potential role in drug resistance in cancer treatment | Q37370626 | ||
| A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor | Q38295096 | ||
| Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene | Q38351040 | ||
| Human pregnane X receptor and resistance to chemotherapy in prostate cancer | Q40059227 | ||
| Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites | Q40118167 | ||
| Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes | Q40387722 | ||
| Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells. | Q40550555 | ||
| DNA topoisomerases: essential enzymes and lethal targets | Q40678987 | ||
| Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor. | Q40774573 | ||
| Topoisomerase I inhibitors: topotecan and irenotecan | Q40807397 | ||
| The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module | Q40916686 | ||
| Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells | Q41656875 | ||
| Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs | Q42289176 | ||
| Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents | Q44104236 | ||
| Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. | Q44241604 | ||
| Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. | Q44550541 | ||
| The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion | Q45223647 | ||
| Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats | Q45240285 | ||
| Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice | Q46679430 | ||
| Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole | Q48684324 | ||
| Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. | Q52569931 | ||
| Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. | Q52573580 | ||
| The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. | Q54577544 | ||
| Phase I clinical and pharmacological studies of 20-(S)-camptothecin and 20-(S)-9-nitrocamptothecin as anticancer agents | Q71969766 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 999-1008 | |
| P577 | publication date | 2010-05-26 | |
| P1433 | published in | Journal of Pharmacology and Experimental Therapeutics | Q1500272 |
| P1476 | title | Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor | |
| P478 | volume | 334 |
| Q37303129 | A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay |
| Q38970938 | Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. |
| Q50249231 | Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay |
| Q34196976 | Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe |
| Q37184675 | Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor |
| Q88551397 | Effect of Gambogenic Acid on Cytochrome P450 1A2, 2B1 and 2E1, and Constitutive Androstane Receptor in Rats |
| Q48131744 | Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity |
| Q35759931 | Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells |
| Q64252239 | Inhibitory Effect of Berberine on Broiler P-glycoprotein Expression and Function: In Situ and In Vitro Studies |
| Q57269371 | Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo |
| Q35919726 | Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. |
| Q34349313 | Overcoming drug resistance by regulating nuclear receptors |
| Q36640752 | PXR antagonists and implication in drug metabolism |
| Q34345049 | Pregnane X receptor and drug-induced liver injury. |
| Q38039759 | Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response |
| Q50070843 | Probing ligand structure-activity relationships in pregnane X receptor (PXR): efavirenz and 8-hydroxyefavirenz exhibit divergence in activation. |
| Q36605392 | Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes |
| Q35975156 | Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation |
| Q35938150 | Small-molecule modulators of PXR and CAR. |
| Q35748820 | Small-molecule modulators of the constitutive androstane receptor. |
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