| P2093 | author name string | Taosheng Chen | |
| P2860 | cites work | SXR, a novel steroid and xenobiotic-sensing nuclear receptor | Q22003995 |
| | A multidrug resistance transporter from human MCF-7 breast cancer cells | Q22008574 |
| | The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions | Q24310512 |
| | Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naïve patients with chronic hepatitis B. | Q46175222 |
| | P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion | Q46430437 |
| | Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents | Q46689471 |
| | Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole | Q48684324 |
| | Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues | Q48913115 |
| | Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes | Q50092409 |
| | Effects of rifampicin on global gene expression in human small intestine. | Q53511289 |
| | Multidrug resistance: can new drugs help chemotherapy score against cancer? | Q53940527 |
| | Renal secretion of vinblastine, vincristine and colchicine in vivo. | Q54221426 |
| | The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. | Q54577544 |
| | Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells | Q69700007 |
| | Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil | Q70721995 |
| | Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP). Updated results of a randomized study. Groupe Français des Myélodysplasies (GFM) and Groupe GOELAMS | Q73028075 |
| | Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum) | Q73145709 |
| | Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction | Q73148551 |
| | MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment | Q73393104 |
| | St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4 | Q73443725 |
| | Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition | Q79843123 |
| | Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia: a randomised phase II trial from HOVON, the Dutch-Belgian Haemato-Oncology Working | Q80407516 |
| | Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating | Q82534367 |
| | Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier | Q41160310 |
| | Functional involvement of P-glycoprotein in blood-brain barrier | Q41969434 |
| | A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor | Q43129895 |
| | Modulation of T lymphocyte function by the pregnane X receptor | Q43155105 |
| | Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice. | Q43263789 |
| | Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. | Q43683607 |
| | Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen | Q43957743 |
| | Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. | Q44083625 |
| | P-glycoprotein-mediated intestinal and biliary digoxin transport in humans | Q44351189 |
| | Induction of Cytochrome P450 3A by Paclitaxel in Mice: Pivotal Role of the Nuclear Xenobiotic Receptor, Pregnane X Receptor | Q44403653 |
| | Expression and potential roles of pregnane X receptor in endometrial cancer | Q44582531 |
| | Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene | Q44769966 |
| | Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes | Q44835141 |
| | Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier | Q45025187 |
| | Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. | Q45062160 |
| | A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen | Q45125373 |
| | Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Gr | Q45130073 |
| | Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. | Q45145266 |
| | Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line | Q24338329 |
| | The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity | Q24630723 |
| | Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues | Q24633406 |
| | Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction | Q24646162 |
| | Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells | Q24647234 |
| | The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity | Q27632611 |
| | Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism | Q27641100 |
| | A nuclear receptor-like pathway regulating multidrug resistance in fungi | Q27650217 |
| | The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue | Q28143699 |
| | The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux | Q28186424 |
| | Structural insights into the promiscuity and function of the human pregnane X receptor | Q28203830 |
| | Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin | Q28211706 |
| | An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway | Q28263744 |
| | PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators | Q28281902 |
| | Cancer statistics, 2009 | Q29547625 |
| | Targeting multidrug resistance in cancer | Q29616803 |
| | The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse | Q31875556 |
| | The effect of rifampin administration on the disposition of fexofenadine | Q32156844 |
| | P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing | Q33214448 |
| | Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma | Q33231052 |
| | Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells | Q33247258 |
| | Computational discovery of novel low micromolar human pregnane X receptor antagonists | Q33346738 |
| | The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor | Q33642959 |
| | Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. | Q33728760 |
| | Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites | Q33832954 |
| | Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites | Q33837172 |
| | The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors | Q33881484 |
| | Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs | Q34059522 |
| | P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes. | Q34091538 |
| | Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor | Q34128854 |
| | The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein | Q34235311 |
| | Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. | Q34272156 |
| | The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation | Q34298925 |
| | Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation | Q34324051 |
| | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants | Q34488592 |
| | Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines | Q35076110 |
| | ABC of oral bioavailability: transporters as gatekeepers in the gut. | Q35591517 |
| | The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability | Q35620976 |
| | CAR and PXR: the xenobiotic-sensing receptors | Q35944704 |
| | Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense | Q36104162 |
| | Animal models of xenobiotic receptors in drug metabolism and diseases | Q36363133 |
| | Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. | Q36498311 |
| | The antiapoptotic role of pregnane X receptor in human colon cancer cells | Q36512415 |
| | Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor | Q36788463 |
| | PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics | Q36995453 |
| | Nuclear receptors: decoding metabolic disease | Q37006389 |
| | Resistance to chemotherapy in cancer: a complex and integrated cellular response | Q37079652 |
| | Inflammation and altered drug clearance in cancer: transcriptional repression of a human CYP3A4 transgene in tumor-bearing mice | Q37128654 |
| | Nuclear receptor drug discovery | Q37229006 |
| | Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression | Q37284901 |
| | Drug ratio-dependent antagonism: a new category of multidrug resistance and strategies for its circumvention | Q37641849 |
| | Reversing agents for ATP-binding cassette drug transporters | Q37641851 |
| | Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. | Q38288114 |
| | A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor | Q38295096 |
| | Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). | Q38320034 |
| | Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver | Q38322847 |
| | SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors | Q39740090 |
| | Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells | Q39941217 |
| | Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer | Q39944384 |
| | Human pregnane X receptor and resistance to chemotherapy in prostate cancer | Q40059227 |
| | Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells | Q40106162 |
| | Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines. | Q40117745 |
| | Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites | Q40118167 |
| | Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. | Q40152929 |
| | Characterization of gene rearrangements leading to activation of MDR-1. | Q40234896 |
| | Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions | Q40275355 |
| | Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines | Q40291045 |
| | Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis | Q40349824 |
| | Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs | Q40386853 |
| | A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression | Q40399800 |
| | Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver | Q40519268 |
| | Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1. | Q40788757 |
| | The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin | Q40851439 |
| | The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module | Q40916686 |
| P433 | issue | 13 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | multiple drug resistance | Q643839 |
| | antineoplastic resistance | Q13416904 |
| P304 | page(s) | 1257-1264 | |
| P577 | publication date | 2010-08-04 | |
| P1433 | published in | Advanced Drug Delivery Reviews | Q2825362 |
| P1476 | title | Overcoming drug resistance by regulating nuclear receptors | |
| P478 | volume | 62 | |