Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia

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Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...730444W
P356DOI10.1371/JOURNAL.PONE.0030444
P932PMC publication ID3261195
P698PubMed publication ID22279591
P5875ResearchGate publication ID221779619

P50authorWilliam E. SonntagQ56980500
Junie WarringtonQ42638093
P2093author name stringYong Woo Lee
Anna Csiszar
Matthew Mitschelen
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Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiationQ48182263
Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory responseQ48238259
Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: a potential rat model of vascular dementiaQ48265874
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Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathyQ33354053
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Hippocampal neuron number is unchanged 1 year after fractionated whole-brain irradiation at middle age.Q33585529
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Chronic neurological deficits in mice after perinatal hypoxia and ischemia correlate with hemispheric tissue loss and white matter injury detected by MRIQ33941926
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Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats.Q34139529
Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesisQ34329749
Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brainQ35843315
Whole-brain radiotherapy in the management of brain metastasisQ36416756
Isolation and perivascular localization of mesenchymal stem cells from mouse brainQ36818251
Hypoxia: a key regulator of angiogenesis in cancerQ36866153
Cranial radiation therapy and damage to hippocampal neurogenesisQ37299470
Pericyte signaling in the neurovascular unitQ37344142
Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD.Q37399854
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cellsQ37419124
Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gainQ37468121
Requirement of adult-born neurons for hippocampus-dependent learning.Q37901806
Functions for adult neurogenesis in memory: an introduction to the neurocomputational approach and to its contribution.Q37920366
Stem cell factor stimulates neurogenesis in vitro and in vivoQ39738276
Memory deficits associated with senescence: A neurophysiological and behavioral study in the ratQ40232008
Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in miceQ42703790
Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxiaQ43066965
Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesisQ43262578
Irradiation to the immature brain attenuates neurogenesis and exacerbates subsequent hypoxic-ischemic brain injury in the adultQ43267928
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice.Q44399500
Hypoxia, HIF1 and glucose metabolism in the solid tumourQ44633634
Early radiation-induced endothelial cell loss and blood-spinal cord barrier breakdown in the rat spinal cordQ44733968
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)e30444
P577publication date2012-01-18
P1433published inPLOS OneQ564954
P1476titleWhole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia
P478volume7

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