Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications

scientific article published on October 2013

Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000354227
P932PMC publication ID4309372
P698PubMed publication ID24107797

P50authorWilliam E. SonntagQ56980500
Zoltan UngvariQ60324829
Junie WarringtonQ42638093
P2093author name stringYong Woo Lee
Anna Csiszar
Nicole Ashpole
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Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculatureQ28750081
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Synaptic pruning by microglia is necessary for normal brain developmentQ29615591
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Vascular niche for adult hippocampal neurogenesisQ29619395
Endothelial/pericyte interactionsQ29619802
Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropilQ30307737
Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cellsQ30438261
The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survivalQ30476883
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Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cellsQ31077883
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Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursorsQ33887795
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Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemiaQ44345661
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice.Q44399500
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Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampusQ48307666
An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis.Q48308693
Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus.Q48346310
VEGF overexpression enhances striatal neurogenesis in brain of adult rat after a transient middle cerebral artery occlusionQ48388791
An experimental study of acute radiation-induced cognitive dysfunction in a young rat modelQ48432887
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Double-tracer study of the fine regional blood-brain glucose transfer in the rat by computer-assisted autoradiographyQ48483279
Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgeryQ48542815
Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in ratsQ48632357
Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injuryQ48664689
Vascular damage after fractionated whole-brain irradiation in ratsQ48722398
Effects of treatment on long-term survivors with malignant astrocytomasQ48847104
Surgical injury induces the mobilization of endothelial progenitor cellsQ48879687
Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier.Q50487583
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.Q50515193
Bone marrow contributes simultaneously to different neural types in the central nervous system through different mechanisms of plasticity.Q50527344
Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution.Q50695105
Response of astrocytes and microglia/macrophages to brain injury after bone marrow stromal cell transplantation: A quantitative studyQ51537324
Circulating endothelial cells as potential markers of atherosclerosis.Q51851061
Memory function before and after whole brain radiotherapy in patients with and without brain metastases.Q51958297
Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.Q51965379
Cognitive dysfunction and histological findings in adult rats one year after whole brain irradiation.Q52124923
Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury.Q53636098
Mobilized Endothelial Progenitor Cells by Granulocyte-Macrophage Colony-Stimulating Factor Accelerate Reendothelialization and Reduce Vascular Inflammation After Intravascular RadiationQ53649329
Mobilization of circulating vascular progenitors in cancer patients receiving external beam radiation in response to tissue injury.Q54725465
Sustained elevation of NF-kappaB DNA binding activity in radiation-induced lung damage in rats.Q54735804
Radiation-induced regional cerebral blood volume (rCBV) changes in normal brain and low-grade astrocytomas: quantification and time and dose-dependent occurrence.Q55475357
Blood flow changes following 137Cs irradiation in a rat glioma model.Q55486095
Transient inflammation in neurogenic regions after irradiation of the developing brainQ56880497
Relationship Between Neurocognitive Function and Quality of Life After Whole-Brain Radiotherapy in Patients With Brain MetastasisQ57618238
Chronic Hypoxia–Induced Angiogenesis Normalizes Blood Pressure in Spontaneously Hypertensive RatsQ57983639
Elevated levels of circulating endothelial progenitor cells in head and neck cancer patientsQ59417400
CD34 + and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart FailureQ61403155
The Neurovascular Unit and the Key Role of Astrocytes in the Regulation of Cerebral Blood FlowQ63363224
Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layerQ73789701
Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivoQ74570325
SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injuryQ75351325
Circulating endothelial cells: life, death, detachment and repair of the endothelial cell layerQ77070687
Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor familiesQ77625551
Mobilization of endothelial precursor cells: systemic vascular response to musculoskeletal traumaQ79139212
Ionizing radiation stimulates secretion of pro-inflammatory cytokines: dose-response relationship, mechanisms and implicationsQ79314692
Transplantation of endothelial progenitor cells accelerates dermal wound healing with increased recruitment of monocytes/macrophages and neovascularizationQ81008614
Endothelial injury induced by coronary angioplasty triggers mobilization of endothelial progenitor cells in patients with stable coronary artery diseaseQ83321296
Gamma-irradiation is more efficient at depleting hippocampal neurogenesis than D-galactose/NaNO₂Q84099683
Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunctionQ84579142
The radioresponse of the central nervous system: a dynamic processQ33900796
Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assayQ34005199
Four faces of cellular senescence.Q34025754
Pericyte physiology.Q34061482
Molecular mechanisms of blood vessel growthQ34134535
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cellsQ34137912
Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats.Q34139529
Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxiaQ34141823
Irradiation induces neural precursor-cell dysfunctionQ34142734
Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesisQ34329749
Early exercise improves cerebral blood flow through increased angiogenesis in experimental stroke rat modelQ34691016
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotypeQ35007977
The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disordersQ35256491
Invited review: permanent radiation myelopathyQ35366656
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotypeQ35378363
Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia--an ultrasound and MRI study.Q35524188
Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brainQ35647943
Role of astrocytes in cerebrovascular regulationQ35674948
Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brainQ35843315
Endothelial progenitor cells: characterization and role in vascular biologyQ35867837
Circulating endothelial (progenitor) cells reflect the state of the endothelium: vascular injury, repair and neovascularizationQ36016862
Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injuryQ36025592
VEGF is a chemoattractant for FGF-2-stimulated neural progenitorsQ36324941
The function and integrity of the neurovascular unit rests upon the integration of the vascular and inflammatory cell systemsQ36352343
Whole-brain radiotherapy in the management of brain metastasisQ36416756
Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunctionQ36453492
Aging-dependent changes in the radiation response of the adult rat brain.Q36498995
Prolonged expression of senescence markers in mice exposed to gamma-irradiationQ36514946
Hypoxia: a key regulator of angiogenesis in cancerQ36866153
Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cellsQ37101882
Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cellsQ37200278
Cranial radiation therapy and damage to hippocampal neurogenesisQ37299470
Pericyte signaling in the neurovascular unitQ37344142
Astrocytes and the regulation of cerebral blood flowQ37375326
Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniquesQ37391943
Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD.Q37399854
From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells.Q37418551
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cellsQ37419124
Defining human endothelial progenitor cellsQ37561425
Requirement of adult-born neurons for hippocampus-dependent learning.Q37901806
Functions for adult neurogenesis in memory: an introduction to the neurocomputational approach and to its contribution.Q37920366
Role of astrocytes in neurovascular coupling.Q37929350
Astrocytes control the development of the migration-promoting vasculature scaffold in the postnatal brain via VEGF signaling.Q38328027
TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73Q38679001
Umbilical cord blood-derived CD34⁺ cells improve outcomes of traumatic brain injury in rats by stimulating angiogenesis and neurogenesisQ39167308
Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusionQ39641555
Stem cell factor stimulates neurogenesis in vitro and in vivoQ39738276
Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cellsQ39786456
Del-1 gene transfer induces cerebral angiogenesis in miceQ39974831
Molecular mechanisms responsible for microglia-derived protection of Sprague-Dawley rat brain cells during in vitro ischemiaQ40487289
Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathyQ40720858
Modification of glucose metabolism in radiation-induced brain injury areas using cervical spinal cord stimulation.Q42454895
Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophinQ42463937
Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cellsQ42498432
Role of inflammation and insulin resistance in endothelial progenitor cell dysfunctionQ42703611
Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in miceQ42703790
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesisQ42718493
G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanismQ42742048
Statin and stromal cell-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vesselsQ42816285
Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurement.Q42905599
Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition.Q42922079
Senescence-associated beta-galactosidase activity expression in aging hippocampal neuronsQ43067483
Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesisQ43262578
Irradiation to the immature brain attenuates neurogenesis and exacerbates subsequent hypoxic-ischemic brain injury in the adultQ43267928
NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cellsQ43292284
Production of basic fibroblast growth factor in cultured rat brain microgliaQ43672765
P433issue6
P921main subjectcognitive dysfunctionQ57859955
P304page(s)445-457
P577publication date2013-10-01
P1433published inJournal of Vascular ResearchQ15755734
P1476titleWhole brain radiation-induced vascular cognitive impairment: mechanisms and implications
P478volume50

Reverse relations

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