Mechanotransduction in development: a growing role for contractility

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Mechanotransduction in development: a growing role for contractility is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1011559394
P356DOI10.1038/NRM2592
P932PMC publication ID2952188
P698PubMed publication ID19197330
P5875ResearchGate publication ID23983671

P2093author name stringChristopher S Chen
Michele A Wozniak
P2860cites workRegulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Mechanism of activation of the Formin protein Daam1Q24657453
Rho-stimulated contractility drives the formation of stress fibers and focal adhesionsQ24671788
Matrix elasticity directs stem cell lineage specificationQ27860761
Tensional homeostasis and the malignant phenotypeQ27860932
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1Q28214701
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatmentQ28247505
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentQ28255124
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transitionQ28257507
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talinQ28505684
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)Q28609825
Actin dynamics control SRF activity by regulation of its coactivator MALQ28646140
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension.Q52561854
The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis.Q52681790
Surface tensions of embryonic tissues predict their mutual envelopment behavior.Q53964473
Models of morphogenesis: the mechanisms and mechanics of cell rearrangementQ56041836
Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and MyogenesisQ57363725
The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservationQ69936238
Glucose metabolite patterns as markers of functional differentiation in freshly isolated and cultured mouse mammary epithelial cellsQ70825655
Silicone rubber substrata: a new wrinkle in the study of cell locomotionQ72128764
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylationQ73316337
A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growthQ73876502
Differences in the regulation of fibroblast contraction of floating versus stressed collagen matricesQ77747916
Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filamentsQ77986114
Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferationQ78734869
Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblastsQ95721045
Soft biological materials and their impact on cell functionQ99232636
Cell intercalation during Drosophila germband extension and its regulation by pair-rule segmentation genesQ52537238
Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila.Q52542281
Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila developmentQ28757802
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1Q29614256
Geometric control of cell life and deathQ29615213
Cell locomotion and focal adhesions are regulated by substrate flexibilityQ29615522
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substratesQ29616030
Local force and geometry sensing regulate cell functionsQ29616036
Cells lying on a bed of microneedles: an approach to isolate mechanical forceQ29617095
Dishevelled controls cell polarity during Xenopus gastrulationQ29619295
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationQ29619296
Emergent patterns of growth controlled by multicellular form and mechanicsQ30447085
Magnetic microposts as an approach to apply forces to living cellsQ30480046
Pulsed contractions of an actin-myosin network drive apical constrictionQ30493161
Wnt/Frizzled signaling controls C. elegans gastrulation by activating actomyosin contractilityQ30497437
In vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses.Q30854613
Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila.Q30859086
Mechanical induction of Twist in the Drosophila foregut/stomodeal primordiumQ31154597
Apoptotic force and tissue dynamics during Drosophila embryogenesisQ33370520
Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesisQ33382061
Fibronectin controls capillary endothelial cell growth by modulating cell shapeQ33572594
Mechanical feedback as a possible regulator of tissue growthQ33927284
Viscoelastic properties of living embryonic tissues: a quantitative studyQ34167743
Role of basal lamina in neoplastic disorganization of tissue architectureQ34276175
Defining the mammalian CArGomeQ34338820
Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkagesQ34415326
folded gastrulation, cell shape change and the control of myosin localization.Q34445867
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarityQ34455099
Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryosQ34646681
Caenorhabditis elegans morphogenesis: the role of the cytoskeleton in elongation of the embryoQ34692059
Dendritic fibroblasts in three-dimensional collagen matricesQ34764057
Border-cell migration: the race is on.Q35038279
On the mechanism of wing size determination in fly developmentQ35676666
Is mechano-sensitive expression of twist involved In mesoderm formation?Q35893690
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signalingQ36118275
Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrataQ36209690
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironmentsQ36322021
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrixQ36324827
Stretch-dependent growth and differentiation in vascular smooth muscle: role of the actin cytoskeletonQ36333417
A cytoplasmic clock with the same period as the division cycle in Xenopus eggsQ36352644
Wnt signaling: complexity at the surface.Q36380540
The role of secondary mesenchyme cells during sea urchin gastrulation studied by laser ablationQ36440772
The social lives of migrating cells in DrosophilaQ36517163
An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis.Q36874813
Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tensionQ36921506
Orchestrating size and shape during morphogenesisQ36997696
Variation and robustness of the mechanics of gastrulation: the role of tissue mechanical properties during morphogenesisQ37070510
The role of matrix stiffness in regulating cell behaviorQ37096921
Mechanotransduction gone awryQ37158222
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitroQ37320767
Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent mannerQ38335145
The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanismsQ40273270
Developmental biology. Apoptosis turbocharges epithelial morphogenesisQ40921632
The dorsal involuting marginal zone stiffens anisotropically during its convergent extension in the gastrula of Xenopus laevisQ40971251
Observations on the sorting-out of embryonic cells in monolayer cultureQ41067014
Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migrationQ41668247
Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranesQ42440790
Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevisQ42514448
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanismQ43812071
The events of the midblastula transition in Xenopus are regulated by changes in the cell cycleQ43959579
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesisQ43998282
Role of cell shape in growth controlQ44152787
Forces for morphogenesis investigated with laser microsurgery and quantitative modelingQ44307030
The mechanics of notochord elongation, straightening and stiffening in the embryo of Xenopus laevis.Q45942791
The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells.Q46018293
A fiber optic system for measuring dynamic mechanical properties of embryonic tissues.Q46032227
Planar cell polarity signalling controls cell division orientation during zebrafish gastrulationQ46041904
Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shearQ46072489
Capping of surface receptors and concomitant cortical tension are generated by conventional myosinQ46093865
Tensile properties of embryonic epithelia measured using a novel instrumentQ46637988
Xenopus Gastrulation without a blastocoel roofQ46706845
Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.Q47070688
Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migrationQ47071318
The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradationQ47071320
A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulationQ47071598
Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closureQ47072105
Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movementsQ47073597
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongationQ47363099
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells.Q50930088
Measuring mechanical properties of embryos and embryonic tissues.Q50961321
Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos.Q51948974
Tensile forces govern germ-layer organization in zebrafish.Q51961232
Cell shape changes during gastrulation in Drosophila.Q52448656
P433issue1
P921main subjectmechanotransductionQ11936292
P304page(s)34-43
P577publication date2009-01-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleMechanotransduction in development: a growing role for contractility
P478volume10

Reverse relations

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Q38563324Physical Principles of Nanoparticle Cellular Endocytosis.
Q35414785Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes
Q90422674Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
Q91344628Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development
Q37852177Polycystins, focal adhesions and extracellular matrix interactions
Q92608702Polymeric sheet actuators with programmable bioinstructivity
Q42035396Preparation of DNA-crosslinked polyacrylamide hydrogels
Q38994004Proliferation of preosteoblasts on TiO2 nanotubes is FAK/RhoA related.
Q30492151Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis
Q47683450Properties of Life: Toward a Coherent Understanding of the Organism.
Q30498046Punctuated actin contractions during convergent extension and their permissive regulation by the non-canonical Wnt-signaling pathway.
Q36601156Pushing, pulling, and squeezing our way to understanding mechanotransduction
Q30573124Quantifying cell-generated mechanical forces within living embryonic tissues
Q55138940Quantifying compressive forces between living cell layers and within tissues using elastic round microgels.
Q37926719Quantitative microscopy and imaging tools for the mechanical analysis of morphogenesis
Q48165081Rapid dynamics of cell-shape recovery in response to local deformations
Q37211716Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical projection stereolithography
Q54943752Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding.
Q30496712Real-time single-cell response to stiffness.
Q35051293Reconstitution of contractile actomyosin bundles
Q64071203Regulation of Actin Dynamics in the Somatic Gonad
Q38182134Regulation of RhoA activity by adhesion molecules and mechanotransduction
Q34160947Regulation of YAP by mechanical strain through Jnk and Hippo signaling
Q38369726Regulation of tissue morphodynamics: an important role for actomyosin contractility
Q92578203Regulatory networks in mechanotransduction reveal key genes in promoting cancer cell stemness and proliferation
Q47656420Relating cell shape and mechanical stress in a spatially disordered epithelium using a vertex-based model.
Q37315419Relative impact of uniaxial alignment vs. form-induced stress on differentiation of human adipose derived stem cells.
Q41965429Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D.
Q38561291Review of cellular mechanotransduction on micropost substrates
Q27309043Role of Mechanical Cues in Cell Differentiation and Proliferation: A 3D Numerical Model
Q38622448Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Q35083175Role of mechanical factors in fate decisions of stem cells.
Q48197838Role of substrate biomechanics in controlling (stem) cell fate: Implications in regenerative medicine.
Q34280133Roles of the cytoskeleton in regulating EphA2 signals
Q33349930Shaping the meristem by mechanical forces
Q35128225Shear stress induced by an interstitial level of slow flow increases the osteogenic differentiation of mesenchymal stem cells through TAZ activation
Q36637373Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity
Q51530448Silicon chips detect intracellular pressure changes in living cells.
Q36250975Simultaneous measurement of the Young's modulus and the Poisson ratio of thin elastic layers
Q37365100Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling
Q47305502Single-cell mechanical phenotype is an intrinsic marker of reprogramming and differentiation along the mouse neural lineage.
Q34455376Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo
Q44242899Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice
Q42351558Slow stretching that mimics embryonic growth rate stimulates structural and mechanical development of tendon-like tissue in vitro.
Q46095468Spatial distributions of pericellular stiffness in natural extracellular matrices are dependent on cell-mediated proteolysis and contractility.
Q28241236Spatiotemporal constraints on the force-dependent growth of focal adhesions
Q47780338Spatiotemporal hydrogel biomaterials for regenerative medicine.
Q90287929Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs
Q30660640Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment
Q35898838Substrate stress relaxation regulates cell spreading.
Q33994731Synergistic regulation of cell function by matrix rigidity and adhesive pattern.
Q38536543Synthetic Extracellular Microenvironment for Modulating Stem Cell Behaviors.
Q41265082Systems Chemo-Biology and Transcriptomic Meta-Analysis Reveal the Molecular Roles of Bioactive Lipids in Cardiomyocyte Differentiation
Q33348048T cell receptor triggering by force
Q50024058TGFβ1-induced expression of caldesmon mediates epithelial-mesenchymal transition.
Q58725527Tailoring the Interface of Biomaterials to Design Effective Scaffolds
Q47630488Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.
Q61773841Tension in the vasculature
Q41529348The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching.
Q55081275The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis.
Q26750608The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases
Q57346662The Superficial Mechanical and Physical Properties of Matrix Microenvironment as Stem Cell Fate Regulator
Q40998185The animal sensorimotor organization: a challenge for the environmental complexity thesis
Q37205924The contribution of cellular mechanotransduction to cardiomyocyte form and function
Q36437970The effect of growth factor environment on fibroblast morphological response to substrate stiffness
Q35615571The effect of growth-mimicking continuous strain on the early stages of skeletal development in micromass culture
Q38923271The effects of oxidative stress on the compressive damage thresholds of C2C12 mouse myoblasts: implications for deep tissue injury.
Q53578298The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization.
Q36628612The emerging role of protein kinase Cθ in cytoskeletal signaling
Q38561063The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking.
Q56533571The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation
Q55287510The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation.
Q33348317The mechanics behind plant development
Q37791098The mechanics of development: Models and methods for tissue morphogenesis
Q37109498The role of mechanical loading in tendon development, maintenance, injury, and repair
Q37785158Theoretical Concepts and Models of Cellular Mechanosensing
Q84859409Three-dimensional biomaterials for the study of human pluripotent stem cells
Q39156689Three-dimensional scaffolds of carbonized polyacrylonitrile for bone tissue regeneration
Q36588631Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells
Q58660991Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Q56533245Tunable molecular tension sensors reveal extension-based control of vinculin loading
Q30394341Two-bubble acoustic tweezing cytometry for biomechanical probing and stimulation of cells
Q57476778Ultrafast epithelial contractions provide insights into contraction speed limits and tissue integrity
Q39193541Ultrasound can modulate neuronal development: impact on neurite growth and cell body morphology
Q35679245Understanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation
Q37390923Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions
Q38026497United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.
Q27332282Universally Conserved Relationships between Nuclear Shape and Cytoplasmic Mechanical Properties in Human Stem Cells
Q50096823Unlocking the secrets to regenerating cardiac tissue: an update
Q29030919Using biomaterials to study stem cell mechanotransduction, growth and differentiation
Q39353525Viscoelastic hydrogels for 3D cell culture
Q61805370Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
Q42557716Why is cytoskeletal contraction required for cardiac fusion before but not after looping begins?
Q39091458YAP is essential for 3D organogenesis withstanding gravity
Q55342167β-Catenin-dependent mechanotransduction dates back to the common ancestor of Cnidaria and Bilateria.

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