Tofacitinib for the treatment of rheumatoid arthritis

scientific article

Tofacitinib for the treatment of rheumatoid arthritis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1586/ECI.12.19
P698PubMed publication ID22607178

P2093author name stringAndrea Barranjard Vannucci Lomonte
Cristiano A F Zerbini
P2860cites workCartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritisQ38274571
Cadherin-11 in synovial lining formation and pathology in arthritisQ40178718
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destructionQ41927546
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-betaQ42096868
Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 InhibitorQ44639305
The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine modelsQ44695040
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trialQ44930010
Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primatesQ46428222
Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primatesQ46868410
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial.Q51866375
Kinase inhibitors attract attention as oral rheumatoid arthritis drugs.Q54683529
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Regulatory T cells in rheumatoid arthritisQ24816793
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6Q27661705
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
A quantitative analysis of kinase inhibitor selectivityQ28264038
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damageQ28287540
Evolving concepts of rheumatoid arthritisQ29618020
Phenotypic and functional features of human Th17 cellsQ29619323
Jaks and STATs: biological implicationsQ29619657
New insights into the regulation of T cells by gamma(c) family cytokinesQ33623326
Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists [...]Q33665938
Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant RejectionQ33755282
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritisQ34084020
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).Q34169114
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.Q34288951
Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort).Q34506884
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placeboQ34989826
Regulation of JAK-STAT signalling in the immune systemQ35605437
Cytokine networks--towards new therapies for rheumatoid arthritisQ36577367
Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosisQ36927749
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
tofacitinibQ3530324
P304page(s)319-331
P577publication date2012-05-01
P1433published inExpert Review of Clinical ImmunologyQ15733763
P1476titleTofacitinib for the treatment of rheumatoid arthritis
P478volume8

Reverse relations

cites work (P2860)
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Q38129724Cell-signaling therapy in rheumatoid arthritis
Q45332740Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes
Q37626617Intracellular Signaling Pathways in Rheumatoid Arthritis
Q38751230JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.
Q99240942JAK/STAT pathway in pathology of rheumatoid arthritis (Review)
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Q42537908Oral janus kinase inhibitor for the treatment of rheumatoid arthritis: tofacitinib
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Q24198120Tofacitinib for rheumatoid arthritis
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Q42160873tert-Butyl N-[(3R,4R)-1-(2-cyano-acet-yl)-4-methyl-piperidin-3-yl]-N-methyl-carbamate.

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