The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis

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The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis is …
instance of (P31):
scholarly articleQ13442814
meta-analysisQ815382
review articleQ7318358

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P356DOI10.1007/S10067-013-2329-9
P932PMC publication ID3778229
P698PubMed publication ID23877486
P5875ResearchGate publication ID251234925

P50authorPaweł KawalecQ95945656
Andrzej PilcQ43012502
P2093author name stringAlicja Mikrut
Natalia Wiśniewska
P2860cites workSystematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritisQ21134808
2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritisQ26828418
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial.Q51866375
A proposed revision to the ACR20: The hybrid measure of American College of Rheumatology responseQ57169478
Tofacitinib or Adalimumab versus Placebo in Rheumatoid ArthritisQ58912330
A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate aloneQ82066071
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexateQ84127900
Discontinuation of anti-TNF-α therapy in a Chinese cohort of patients with rheumatoid arthritisQ84675149
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritisQ84751886
Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugsQ85001070
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statementQ27860606
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Assessing the quality of reports of randomized clinical trials: is blinding necessary?Q27860973
Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustmentQ33668201
Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomesQ34132778
Tofacitinib for the treatment of rheumatoid arthritisQ34275878
Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70Q34523450
Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic studyQ34561675
Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysisQ34677487
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placeboQ34989826
A meta-analysis of the efficacy and safety of using infliximab for the treatment of rheumatoid arthritis.Q37601368
JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinicalQ38065100
A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritisQ38097494
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trialQ45842857
American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritisQ47643186
P275copyright licenseCreative Commons Attribution-NonCommercial 2.0 GenericQ44128984
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectenzymeQ8047
rheumatoid arthritisQ187255
heterocyclic compoundQ193430
meta-analysisQ815382
systematic reviewQ1504425
mechanism of actionQ3271540
pyrroleQ67954132
pyrimidineQ47069735
P304page(s)1415-1424
P577publication date2013-07-23
2013-10-01
P1433published inClinical RheumatologyQ15754927
P1476titleThe effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis
P478volume32