Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment

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Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2125.2009.03570.X
P932PMC publication ID2824475
P698PubMed publication ID20233177
P5875ResearchGate publication ID42108260

P50authorStanley B CohenQ91720749
P2093author name stringVincent Chow
Robert R Labadie
Samuel H Zwillich
Bethanie Wilkinson
P2860cites workMolecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesQ24313200
Regulation of JAK3 expression and activation in human B cells and B cell malignanciesQ24316337
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7Q24679411
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCIDQ28241595
Cytokines and their role in lymphoid development, differentiation and homeostasisQ30891389
American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis.Q34782898
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placeboQ34989826
Cells of the synovium in rheumatoid arthritis. T lymphocytes.Q35769049
B cells: a fundamental role in the pathogenesis of rheumatoid arthritis?Q36106119
A meta-analysis of the efficacy and toxicity of combining disease-modifying anti-rheumatic drugs in rheumatoid arthritis based on patient withdrawalQ36200678
Improved health-related quality of life with effective disease-modifying antirheumatic drugs: evidence from randomized controlled trials.Q37038783
Exposure-response modeling using latent variables for the efficacy of a JAK3 inhibitor administered to rheumatoid arthritis patientsQ40147073
A survey of British rheumatologists' DMARD preferences for rheumatoid arthritis.Q44552235
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.Q50779374
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial.Q51866375
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I.Q55047291
Guidelines for the management of rheumatoid arthritis: 2002 UpdateQ56212157
The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse drug reactionsQ81178481
The 2008 American College of Rheumatology recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: where the rubber meets the roadQ81360845
The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not hadQ82132610
Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trialQ82690898
Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasisQ83370441
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmethotrexateQ422232
rheumatoid arthritisQ187255
P304page(s)143-151
P577publication date2010-02-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleCo-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment
P478volume69

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