Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

scientific article

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2012PLoSO...738018I
P356DOI10.1371/JOURNAL.PONE.0038018
P932PMC publication ID3366987
P698PubMed publication ID22675505
P5875ResearchGate publication ID225276635

P50authorPablo E CastilloQ56894635
P2093author name stringR Suzanne Zukin
Naoki Kaneko
Anne M Etgen
Tomoko Inagaki
P2860cites workEnhanced cell death and learning deficits after a mini-stroke in aged hippocampusQ48140456
Neuroprotective effects of estrogen treatment on ischemia-induced behavioural deficits in ovariectomized gerbils at different ages.Q48234256
Effects of gender and estradiol treatment on focal brain ischemiaQ48481118
Selective vulnerability of the hippocampus to ischemia--reversible and irreversible types of ischemic cell damageQ48572821
High expression of GLT-1 in hippocampal CA3 and dentate gyrus subfields contributes to their inherent resistance to ischemia in ratsQ48892881
Increased sensitivity to transient global ischemia in aging rat brain.Q50085757
Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats.Q52027237
Brain aromatase expression after experimental stroke: topography and time course.Q53675731
Estradiol exerts neuroprotective effects when administered after ischemic insultQ73505615
Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astrogliaQ73744988
Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemiaQ81452814
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialQ27860743
G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptorsQ28264108
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neuronsQ28580245
Neuroprotective effects of female gonadal steroids in reproductively senescent female ratsQ30651308
Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female ratsQ33523047
Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticityQ33588830
Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activationQ33595388
Acute estradiol protects CA1 neurons from ischemia-induced apoptotic cell death via the PI3K/Akt pathwayQ33719089
The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1.Q33921182
Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female ratsQ34017363
Physiological consequences of membrane-initiated estrogen signaling in the brainQ34157134
Neuronal estrogen receptor-alpha mediates neuroprotection by 17beta-estradiolQ34171071
The science of stroke: mechanisms in search of treatmentsQ34212337
Delayed neuronal death in the gerbil hippocampus following ischemiaQ34278586
Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiologyQ34320568
Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanismQ34497519
Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotectionQ34530662
Aromatase Cytochrome P450 and Extragonadal Estrogen Play a Role in Ischemic NeuroprotectionQ34542186
Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause.Q34615300
The assessment of non-feminizing estrogens for use in neuroprotectionQ34624609
Menopause and ischaemic stroke: basic, clinical and epidemiological considerations. The role of hormone replacementQ34722303
Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implicationsQ34827433
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation.Q34957102
Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and StressQ35007766
Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.Q35036040
STX, a novel nonsteroidal estrogenic compound, induces rapid action in primate GnRH neuronal calcium dynamics and peptide releaseQ35110836
The ovarian hormone estradiol plays a crucial role in the control of food intake in femalesQ35116172
Estradiol and G1 reduce infarct size and improve immunosuppression after experimental strokeQ35125543
C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotectionQ35198156
Estrogen and the Aging Hippocampal SynapseQ35582670
The use of estrogens and related compounds in the treatment of damage from cerebral ischemia.Q35679182
Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions.Q35749627
Estrogen neuroprotection and the critical period hypothesisQ35785178
Oestrogen signalling and neuroprotection in cerebral ischaemiaQ35882885
Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemiaQ35920205
Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology.Q36323341
Selective vulnerability of the hippocampus in brain ischemiaQ36501847
Different modes of hippocampal plasticity in response to estrogen in young and aged female ratsQ36539192
Acute effects of estrogen on neuronal physiologyQ36569834
Membrane-initiated signaling of estrogen in the brainQ36796994
Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampusQ36854959
MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemiaQ36859370
Estradiol, insulin-like growth factor-I and brain aging.Q36873315
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.Q37083658
Chronic estradiol treatment increases CA1 cell survival but does not improve visual or spatial recognition memory after global ischemia in middle-aged female rats.Q37130054
A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese ratsQ37152082
Estrogen synthesis in the brain--role in synaptic plasticity and memory.Q37187012
Neuroprotective actions of brain aromataseQ37238625
Modulation of synaptic plasticity by brain estrogen in the hippocampusQ37631877
Ischemic stroke in the elderly: an overview of evidenceQ37724591
Estrogen synthesis in the hippocampusQ37914039
A new model of bilateral hemispheric ischemia in the unanesthetized ratQ39259932
Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female ratsQ39699688
Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region.Q42491390
Aromatase inhibitors induce spine synapse loss in the hippocampus of ovariectomized miceQ43185273
A clinical trial of estrogen-replacement therapy after ischemic strokeQ43779426
Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats.Q43972751
Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory StudyQ44948891
Age-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices.Q45089938
Comparison between hippocampus-synthesized and circulation-derived sex steroids in the hippocampus.Q45933651
Estrogen can act via estrogen receptor alpha and beta to protect hippocampal neurons against global ischemia-induced cell death.Q46427696
Estrogen synthesis in the central nucleus of the amygdala following middle cerebral artery occlusion: role in modulating neurotransmissionQ46705595
Neurosteroid synthesis in the hippocampus: role in synaptic plasticityQ46847749
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e38018
P577publication date2012-06-04
P1433published inPLOS OneQ564954
P1476titleEstradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats
P478volume7

Reverse relations

cites work (P2860)
Q64236134Altered Neural Networks in the Papez Circuit: Implications for Cognitive Dysfunction after Cerebral Ischemia
Q38268937Effect of sex and age interactions on functional outcome after stroke
Q35637921Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia
Q36931700High-dose estrogen treatment at reperfusion reduces lesion volume and accelerates recovery of sensorimotor function after experimental ischemic stroke.
Q30539131Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause
Q64074373Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring
Q36672688Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons
Q37069818Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications
Q37220073Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses
Q26795755The Incremental Induction of Neuroprotective Properties by Multiple Therapeutic Strategies for Primary and Secondary Neural Injury
Q36392945The cerebellum as a target for estrogen action

Search more.