The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease

scientific article

The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0021-9150(00)00741-3
P698PubMed publication ID11472726
P5875ResearchGate publication ID11869372

P2093author name stringWeber C
Kontush A
Neuzil J
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Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenaseQ24563459
Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoproteinQ24563896
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherolQ24564131
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Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient miceQ77407922
alpha-tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylationQ77604560
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesisQ77718601
gamma-tocopherol decreases ox-LDL-mediated activation of nuclear factor-kappaB and apoptosis in human coronary artery endothelial cellsQ77767499
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Coexistence of oxidized lipids and alpha-tocopherol in all lipoprotein density fractions isolated from advanced human atherosclerotic plaquesQ77974669
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The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbitsQ31886442
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d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant propertiesQ33654586
The ambivalence of vitamin E in atherogenesisQ33656491
Is NF-kappaB the sensor of oxidative stress?Q33672580
Antioxidant defenses and lipid peroxidation in human blood plasmaQ33688237
Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesionsQ33783079
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The antioxidant paradoxQ33903881
Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cellsQ33905168
Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.Q34127841
Intact human ceruloplasmin oxidatively modifies low density lipoproteinQ34138265
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Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cellsQ34228843
Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesionsQ34236265
Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liverQ34242273
Vitamin E consumption and the risk of coronary heart disease in men.Q34363912
Biokinetics in humans of RRR-alpha-tocopherol: the free phenol, acetate ester, and succinate ester forms of vitamin E.Q34368058
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cellsQ34526444
Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in cultureQ34620804
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.Q35379559
Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaquesQ35751034
Human suction blister interstitial fluid prevents metal ion-dependent oxidation of low density lipoprotein by macrophages and in cell-free systemsQ35764845
gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implicationsQ36083550
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cellsQ36231310
Functional analysis of the human vascular cell adhesion molecule 1 promoterQ36232054
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxisQ36237297
Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipidsQ36297106
Caspase-dependent Cdk activity is a requisite effector of apoptotic death eventsQ36301637
Tolerance and safety of vitamin E: A toxicological position reportQ36313257
Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfacesQ36601900
Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.Q36731862
Presence of hypochlorite-modified proteins in human atherosclerotic lesionsQ37353371
Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulationQ37357656
The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endotheliumQ37358390
Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol contentQ37559293
Role of oxidatively modified LDL in atherosclerosisQ37978587
Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimersQ38299782
Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loopQ38318592
Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cellsQ38326377
Dietary intake, plasma levels of antioxidant vitamins, and oxidative stress in relation to coronary artery disease in elderly subjectsQ39369790
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout miceQ39802780
Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice.Q39808657
Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidasesQ40343992
Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoproteinQ40380142
An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcriptionQ40503880
Is atherosclerosis an immunologically mediated disease?Q40606541
Quantitative evaluation of vitamin E in the treatment of angina pectorisQ40754188
At last, direct evidence that lipoxygenases play a role in atherogenesisQ40850995
The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbateQ40877075
Efflux of hepatic ascorbate: a potential contributor to the maintenance of plasma vitamin C.Q40938051
Antioxidant and redox regulation of gene transcriptionQ40989720
alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation stateQ41019160
The role of oxidized lipoproteins in atherogenesisQ41043422
The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoproteinQ41086883
Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbitsQ41169284
Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiationQ41200257
Constitutive expression of human intercellular adhesion molecule-1 (ICAM-1) is regulated by differentially active enhancing and silencing elementsQ41365660
Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicalsQ41441087
Direct observation of a free radical interaction between vitamin E and vitamin CQ41515338
Antioxidants and atherosclerotic heart diseaseQ41548784
Potential involvement of type II phospholipase A2 in atherosclerosisQ41554170
Low density lipoprotein oxidation and its pathobiological significanceQ41566828
Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis?Q41574079
Effect of the Antioxidant N,N′ -Diphenyl 1,4-Phenylenediamine (DPPD) on Atherosclerosis in ApoE-Deficient MiceQ41671565
The effects of alpha-tocopherol on critical cells in atherogenesisQ41720926
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant propertiesQ41829508
Lipoxygenase treatment render low-density lipoprotein susceptible to Cu2+-catalysed oxidationQ41898182
Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbitsQ41946461
Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide productionQ42185881
Radical-induced chain oxidation of proteins and its inhibition by chain-breaking antioxidantsQ42220105
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesionsQ42479411
Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic anginaQ42538178
Plasma ubiquinol-10 is decreased in patients with hyperlipidaemiaQ42550801
Involvement of 15-lipoxygenase in early stages of atherogenesisQ42942374
Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.Q43827486
Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty (PTCA)Q43977041
Antioxidant vitamin intake and coronary mortality in a longitudinal population studyQ44390925
Vitamin E, antioxidants and lipid peroxidation in experimental atherosclerosis of rabbitsQ44444843
Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbitsQ44512846
Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery diseaseQ44621395
Effect of vitamin E on atherogenesis in LDL receptor-deficient rabbitsQ44853175
Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamstersQ46068468
Redox regulation of NF-kappa B activationQ46098446
Inhibition of NF-kappa B activation by vitamin E derivativesQ46571552
Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL.Q46686309
Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C.Q46712155
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophilsQ46943421
Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancerQ47397466
Monocyte superoxide production is inversely related to normal content of alpha-tocopherol in low-density lipoproteinQ47739528
Alcohol, fish, fibre and antioxidant vitamins intake do not explain population differences in coronary heart disease mortality.Q47824864
Secretory phospholipase A2 and lipoprotein lipase enhance 15-lipoxygenase-induced enzymic and nonenzymic lipid peroxidation in low-density lipoproteinsQ47942846
Vitamin E consumption and the risk of coronary disease in womenQ50126258
Is oxidative stress causally linked to unstable angina pectoris? A study in 100 CAD patients and matched controls.Q50524849
Combined effects of lipid peroxidation and antioxidant status on carotid atherosclerosis in a population aged 59-71 y: The EVA Study. Etude sur le Vieillisement Artériel.Q50981532
Carotenoids, vitamins C and E, and mortality in an elderly population.Q51013318
Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease.Q51034508
Radical-initiated lipid peroxidation in low density lipoproteins: insights obtained from kinetic modeling.Q52298159
Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein.Q52346986
The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E.Q52993512
Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?Q53229607
Increased lipoprotein oxidation in Alzheimer's disease.Q53233479
Copper-induced lipid peroxidation in liposomes, micelles, and LDL: which is the role of vitamin E?Q53806425
Antioxidative activity of ubiquinol-10 at physiologic concentrations in human low density lipoprotein.Q54162492
Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein.Q54189438
ApoptosisQ58492255
Modulation by α- and γ-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells∗Q58863676
α-Tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisationQ61663176
alpha-Tocopherol in atherogenesis: do we know its real role?Q61663177
Oxidation of Free Fatty Acids in Low Density Lipoprotein by 15-Lipoxygenase Stimulates Nonenzymic, α-Tocopherol-mediated Peroxidation of Cholesteryl EstersQ61663178
Requirement for, Promotion, or Inhibition by α-Tocopherol of Radical-Induced Initiation of Plasma Lipoprotein Lipid PeroxidationQ61663179
Oxidation of parenteral lipid emulsion by ambient and phototherapy lights: Potential toxicity of routine parenteral feedingQ61663180
Vascular Superoxide Dismutase Deficiency Impairs Endothelial Vasodilator Function Through Direct Inactivation of Nitric Oxide and Increased Lipid PeroxidationQ61704124
The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoproteinQ67504070
Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish menQ68092393
Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and caroteneQ68289613
Continuous monitoring of in vitro oxidation of human low density lipoproteinQ69611707
Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin EQ69675152
Serum selenium, vitamin antioxidants, and cardiovascular mortality: a 9-year follow-up study in the NetherlandsQ69740766
Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbitsQ69743368
Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin EQ70642104
Relative resistance of the hamster to aortic atherosclerosis in spite of prolonged vitamin E deficiency and dietary hypercholesterolemia. Putative effect of increased HDL?Q70883783
Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patientsQ70917134
Depletion of alpha-tocopherol in human atherosclerotic lesionsQ70932480
Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal womenQ71002942
Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery diseaseQ71003999
Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)Q71060539
Alpha-tocopherol as a reductant for Cu(II) in human lipoproteins. Triggering role in the initiation of lipoprotein oxidationQ71070423
Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the ElderlyQ71224908
Macrophages require both iron and copper to oxidize low-density lipoprotein in Hanks' balanced salt solutionQ71557574
Vitamin E: a sensor and an information transducer of the cell oxidation stateQ71576298
Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): a simple test for tocopherol-mediated peroxidation of LDL lipidsQ71583934
Vitamin E supplementation with interferon-gamma administration retards immune dysfunction during murine retrovirus infectionQ71587219
Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cellsQ71682090
Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alphaQ71693108
alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanismQ71785121
Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and AscorbateQ71799137
Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophagesQ71816056
3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidationQ71859988
Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbitsQ72102989
Serum antioxidants and myocardial infarction. Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction?Q72193248
The effect of alpha-tocopherol supplementation on LDL oxidation. A dose-response studyQ72235647
Vitamin E and fatty acid intervention does not attenuate the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbitsQ72235689
Relation of vascular oxidative stress, alpha-tocopherol, and hypercholesterolemia to early atherosclerosis in hamstersQ72235714
Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol-10 and polyunsaturated fatty acid contentQ72315473
Vitamin EQ72414750
Vitamin E or probucol as donors for oxidation of human low-density lipoprotein by peroxidases/H2O2Q72561490
Reduction of copper, but not iron, by human low density lipoprotein (LDL). Implications for metal ion-dependent oxidative modification of LDLQ72631357
Antioxidants in adipose tissue and risk of myocardial infarction: the EURAMIC StudyQ72657326
Kinetic study of free-radical-scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherol quinone) in solutionQ72812358
Prooxidant role of vitamin E in copper induced lipid peroxidationQ72911915
Direct copper reduction by macrophages. Its role in low density lipoprotein oxidationQ73119309
Role of alpha-tocopheroxyl radical in the initiation of lipid peroxidation in human low-density lipoprotein exposed to horse radish peroxidaseQ73139603
Alpha- and beta-carotenes in low density lipoprotein are the preferred target for nitric oxide-induced oxidationQ73224129
Vitamin E supplementation and cardiovascular events in high-risk patientsQ73365511
Time-course of oxidation of lipids in human cerebrospinal fluid in vitroQ73398863
Regulation of cdk2 activity in endothelial cells that are inhibited from growth by cell contactQ73536882
Plasma and LDL levels of major lipophilic antioxidants are similar in patients with advanced atherosclerosis and age-matched controlsQ73587373
Increased oxidation of LDL in patients with coronary artery disease is independent from dietary vitamins E and CQ73596765
Alpha-tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoproteinQ73762580
Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cellsQ73954435
Copper ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein B100, but they are reduced at other sites on LDLQ73966017
Dietary antioxidants do not reduce fatty streak formation in the C57BL/6 mouse atherosclerosis modelQ74100288
Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient miceQ74290882
Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitriteQ74540509
The macrophage scavenger receptor type A directs modified proteins to antigen presentationQ74578825
Vitamin E ingestion does not improve arterial endothelial dysfunction in older adultsQ77340581
P433issue2
P304page(s)257-283
P577publication date2001-08-01
P1433published inAtherosclerosisQ4813570
P1476titleThe role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease
P478volume157

Reverse relations

cites work (P2860)
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