Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

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Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans is …
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scholarly articleQ13442814

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P356DOI10.1038/NM1128
P8608Fatcat IDrelease_m2ddk4rydnholgxtholbnhilm4
P698PubMed publication ID15502839
P5875ResearchGate publication ID8214021

P50authorAdrian V. S. HillQ22278197
Sarah GilbertQ30513802
Helen McShaneQ58870907
Ansar PathanQ95950628
Kris HuygenQ32072525
Helen FletcherQ42334206
Sheila KeatingQ42769118
P2093author name stringClare R Sander
P2860cites workFailure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosisQ24537176
Immunogenicity and protective efficacy of a tuberculosis DNA vaccineQ44024302
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus AnkaraQ44138669
A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humansQ45661091
Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus AnkaraQ45722508
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humansQ45723463
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunityQ45734062
A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infectionQ45839569
Purification, characterization and identification of a 32 kDa protein antigen of Mycobacterium bovis BCG.Q46738626
A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and diseaseQ46950134
Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimesQ47898136
Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individualsQ57081485
Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cellsQ73420709
Correlates of protective immunity to Mycobacterium tuberculosis in humansQ33956267
Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosisQ34005845
Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A.Q34119135
BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studiesQ34125647
Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysisQ34338450
Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literatureQ34349749
Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosisQ34527217
How can immunology contribute to the control of tuberculosis?Q34572120
Interferon-gamma and skin test responses of schoolchildren in southeast England to purified protein derivatives from Mycobacterium tuberculosis and other species of mycobacteriaQ39585291
Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus.Q43039389
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.Q44022556
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
antimycobacterialQ2853298
Vaccinia virusQ1986297
P304page(s)1240-1244
P577publication date2004-10-24
P1433published inNature MedicineQ1633234
P1476titleRecombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
P478volume10

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Q46630257Protective efficacy of recombinant (Ag85A) BCG Tokyo with Ag85A peptide boosting against Mycobacterium tuberculosis-infected guinea pigs in comparison with that of DNA vaccine encoding Ag85A.
Q35949758Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon
Q38444246Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31.
Q36212676Pulmonary DNA vaccination: concepts, possibilities and perspectives
Q28084282Quest for correlates of protection against tuberculosis
Q42239687Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization.
Q34518560Recombinant BCG as a vaccine vehicle to protect against tuberculosis
Q42739629Recombinant HBHA boosting effect on BCG-induced immunity against Mycobacterium tuberculosis infection
Q30387447Recombinant Mycobacterium bovis BCG as an HIV vaccine vector
Q37191912Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses
Q42829229Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model
Q44080405Robust immune response elicited by a novel and unique Mycobacterium tuberculosis protein using an optimized DNA/protein heterologous prime/boost protocol
Q36980878Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.
Q29620144Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
Q34259027Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial.
Q33807147Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals
Q24647137Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa
Q36888036Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial.
Q33468451Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A
Q28473318Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa
Q45407829Safety and tolerability of recombinant modified vaccinia virus Ankara expressing an HIV-1 gag/multiepitope immunogen (MVA.HIVA) in HIV-1-infected persons receiving combination antiretroviral therapy
Q36287555Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial
Q34899535Schistosoma mansoni antigen Sm-p80: Prophylactic efficacy of a vaccine formulated in human approved plasmid vector and adjuvant (VR 1020 and alum).
Q40273775Sendai Virus Mucosal Vaccination Establishes Lung-Resident Memory CD8 T Cell Immunity and Boosts BCG-Primed Protection against TB in Mice
Q28649845Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A
Q36744991Should a new tuberculosis vaccine be administered intranasally?
Q47745185Strategies to Improve Vaccine Efficacy against Tuberculosis by Targeting Innate Immunity
Q41996442Successes and failures in human tuberculosis vaccine development.
Q37749889Swine influenza vaccines: current status and future perspectives
Q36252595Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis
Q34169888T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections
Q36090185T cell vaccines for microbial infections
Q36799172T-cell activation is an immune correlate of risk in BCG vaccinated infants
Q37951575T-cell-inducing vaccines - what's the future
Q36470057TB vaccine strategies--what is needed to solve a complex problem?
Q37435926TB vaccines: current status and future perspectives
Q38392001TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development
Q36189072Tailoring information provision and consent processes to research contexts: the value of rapid assessments
Q28740954Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A
Q30360726The TB pandemic: an old problem seeking new solutions.
Q90646281The Virulence of Different Vaccinia Virus Strains Is Directly Proportional to Their Ability To Downmodulate Specific Cell-Mediated Immune Compartments In Vivo
Q37548692The candidate TB vaccine, MVA85A, induces highly durable Th1 responses
Q35689134The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis
Q38116351The current state of tuberculosis vaccines
Q33637297The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial
Q37135865The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum
Q33659150The next 10 years for tuberculosis vaccines: do we have the right plans in place?
Q33950119The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults
Q38280134The present and future of tuberculosis vaccinations
Q26796600The re-emergency and persistence of vaccine preventable diseases
Q34261521The secreted lipoprotein, MPT83, of Mycobacterium tuberculosis is recognized during human tuberculosis and stimulates protective immunity in mice
Q37478271The study of novel DNA vaccines against tuberculosis: induction of pathogen-specific CTL in the mouse and monkey models of tuberculosis
Q36191944The success and failure of BCG - implications for a novel tuberculosis vaccine
Q36849770Therapeutic vaccination to treat chronic infectious diseases: current clinical developments using MVA-based vaccines
Q93052065Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection
Q34024201Toward Understanding the Essence of Post-Translational Modifications for the Mycobacterium tuberculosis Immunoproteome
Q30484783Toward novel vaccines against tuberculosis: current hopes and obstacles.
Q90439703Towards new TB vaccines
Q36736465Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis
Q79189338Tuberculosis in humans and animals: are we a threat to each other?
Q36960497Tuberculosis subunit vaccines: from basic science to clinical testing
Q89724634Tuberculosis vaccine development: from classic to clinical candidates
Q37213940Tuberculosis vaccine development: goals, immunological design, and evaluation
Q85075326Tuberculosis vaccine promises sterilizing immunity
Q53753719Tuberculosis vaccines - an update.
Q37878483Tuberculosis vaccines in clinical trials
Q22242669Tuberculosis vaccines: beyond bacille Calmette-Guerin
Q36458393Tuberculosis vaccines: current status and future prospects
Q37754908Tuberculosis vaccines: present and future
Q43105988Tuberculosis: A re-emerging enemy
Q36238724Tuberculosis: from genome to vaccine
Q36872636Tuberculosis: vaccine and drug development
Q34806664Two doses of candidate TB vaccine MVA85A in antiretroviral therapy (ART) naïve subjects gives comparable immunogenicity to one dose in ART+ subjects
Q35913637Unique gene expression profiles in infants vaccinated with different strains of Mycobacterium bovis bacille Calmette-Guerin.
Q36407800Use of recombinant virus-vectored tuberculosis vaccines for respiratory mucosal immunization
Q41148159Using a prime and pull approach, lentivector vaccines expressing Ag85A induce immunogenicity but fail to induce protection against Mycobacterium bovis bacillus Calmette-Guérin challenge in mice
Q37229931Vaccination against paratuberculosis
Q34111604Vaccination with a Sindbis virus-based DNA vaccine expressing antigen 85B induces protective immunity against Mycobacterium tuberculosis
Q36570685Vaccine approaches to prevent tuberculosis
Q44862237Vaccine manufacturing: challenges and solutions
Q35947967Vaccine platform for prevention of tuberculosis and mother-to-child transmission of human immunodeficiency virus type 1 through breastfeeding
Q51989059Vaccine route, dose and type of delivery vector determine patterns of primary CD8+ T cell responses.
Q36689438Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9
Q26992233Vaccines against tuberculosis: where are we and where do we need to go?
Q35666220Vaccines displaying mycobacterial proteins on biopolyester beads stimulate cellular immunity and induce protection against tuberculosis
Q26996673Vaccines for TB: Lessons from the Past Translating into Future Potentials
Q36350586Vaccines for bovine tuberculosis: current views and future prospects.
Q36285657Vaccines for tuberculosis: novel concepts and recent progress
Q36557330Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities
Q33912043Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor
Q35571248Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.
Q36159950Vaccinology at the beginning of the 21st century
Q28768257Variable host-pathogen compatibility in Mycobacterium tuberculosis
Q37274874Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis
Q36802741Viral vector vaccines make memory T cells against malaria.
Q41812230Viral vectors for vaccine applications
Q38053069Virulence factors of the Mycobacterium tuberculosis complex
Q37646066Viruses as vaccine vectors for infectious diseases and cancer
Q82838981[Tuberculosis. Spain is different and the oblivion of the BCG vaccine]
Q33386020rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector

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