Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

scientific article

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2318
P932PMC publication ID4202168
P698PubMed publication ID25226616
P5875ResearchGate publication ID265692389

P50authorFrancesca ChiariniQ57233680
Alice BertainaQ57550705
Franco LocatelliQ60997922
Cecilia EvangelistiQ114412634
Fraia MelchiondaQ114412635
James A. McCubreyQ42317570
Andrea PessionQ54643363
Alberto M MartelliQ56922777
P2093author name stringRobert Bittman
Susan Pyne
Mirella Falconi
Nigel J Pyne
Camilla Evangelisti
Gabriella Teti
Dong Jae Beak
P2860cites workQuantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromesQ80313420
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemiaQ80853383
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagyQ24645466
Crosstalk between apoptosis, necrosis and autophagyQ26829723
Caspase-2 at a glanceQ27025944
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseasesQ28265044
Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agentQ28486289
Autophagy and the Integrated Stress ResponseQ29547398
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Sphingosine-1-phosphate: an enigmatic signalling lipidQ29620563
Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphateQ30416881
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Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancerQ33636769
Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2Q33755206
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistanceQ33755338
A novel sphingosine kinase inhibitor induces autophagy in tumor cellsQ33861997
Sphingosine 1-phosphate and cancerQ34121255
High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer PatientsQ34254350
Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosisQ34303405
The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian CellsQ34385814
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cellsQ35141306
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesisQ35635353
Targeting sphingosine-1-phosphate in hematologic malignanciesQ36011176
Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levelsQ36339232
Unfolded protein response to autophagy as a promising druggable target for anticancer therapyQ36403652
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberineQ36556350
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cellsQ36677955
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.Q36835151
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemiaQ36926129
Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapyQ37192616
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?Q37220643
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapiesQ37285838
The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapyQ37299276
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagyQ37981834
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stressQ38050926
Oncogenic properties of sphingosine kinases in haematological malignancies.Q38092176
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survivalQ38424345
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migrationQ39215469
Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3aQ39328413
Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemiaQ39332231
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.Q39590044
Morphological and biochemical patterns in skeletal muscle apoptosisQ39772858
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patientsQ39881982
Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cellsQ39947772
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicinQ40059172
Sphingosine kinase 1 is up-regulated in colon carcinogenesisQ40345686
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell linesQ40384186
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.Q40883173
Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cellsQ41849432
In vitro anti-leukaemia activity of sphingosine kinase inhibitorQ42445577
mTOR, AMBRA1, and autophagy: an intricate relationshipQ42790841
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosisQ42799996
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancerQ44501429
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signalingQ46085978
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissueQ46516547
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanismQ46666883
Inhibition of MAP kinase by sphingosine and its methylated derivative, N,N-dimethylsphingosineQ47764761
Acute lymphoblastic leukaemiaQ56722375
Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathwaysQ56998115
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
autophagyQ288322
lymphoblastic leukemiaQ18553852
T-cell acute lymphoblastic leukemiaQ55949881
P1104number of pages16
P304page(s)7886-7901
P577publication date2014-09-01
P1433published inOncotargetQ1573155
P1476titleAssessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics
P478volume5

Reverse relations

cites work (P2860)
Q39929088Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach
Q36679531Intracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular Targets
Q56387433Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era
Q35833018PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors.
Q36544596Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.
Q38495744Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies
Q30853652SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
Q42343101Sphingosine kinase 2 and multiple myeloma
Q50021960Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice
Q28552969Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation
Q28066270Targeting autophagy to sensitive glioma to temozolomide treatment
Q90651738Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
Q89552648The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias
Q38909416Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.

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