scholarly article | Q13442814 |
P50 | author | Francesca Chiarini | Q57233680 |
Alice Bertaina | Q57550705 | ||
Franco Locatelli | Q60997922 | ||
Cecilia Evangelisti | Q114412634 | ||
Fraia Melchionda | Q114412635 | ||
James A. McCubrey | Q42317570 | ||
Andrea Pession | Q54643363 | ||
Alberto M Martelli | Q56922777 | ||
P2093 | author name string | Robert Bittman | |
Susan Pyne | |||
Mirella Falconi | |||
Nigel J Pyne | |||
Camilla Evangelisti | |||
Gabriella Teti | |||
Dong Jae Beak | |||
P2860 | cites work | Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes | Q80313420 |
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia | Q80853383 | ||
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy | Q24645466 | ||
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Caspase-2 at a glance | Q27025944 | ||
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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases | Q28265044 | ||
Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent | Q28486289 | ||
Autophagy and the Integrated Stress Response | Q29547398 | ||
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Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer | Q33636769 | ||
Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2 | Q33755206 | ||
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance | Q33755338 | ||
A novel sphingosine kinase inhibitor induces autophagy in tumor cells | Q33861997 | ||
Sphingosine 1-phosphate and cancer | Q34121255 | ||
High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients | Q34254350 | ||
Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis | Q34303405 | ||
The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells | Q34385814 | ||
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells | Q35141306 | ||
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Unfolded protein response to autophagy as a promising druggable target for anticancer therapy | Q36403652 | ||
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine | Q36556350 | ||
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells | Q36677955 | ||
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. | Q36835151 | ||
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia | Q36926129 | ||
Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy | Q37192616 | ||
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction? | Q37220643 | ||
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies | Q37285838 | ||
The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy | Q37299276 | ||
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy | Q37981834 | ||
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress | Q38050926 | ||
Oncogenic properties of sphingosine kinases in haematological malignancies. | Q38092176 | ||
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival | Q38424345 | ||
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration | Q39215469 | ||
Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a | Q39328413 | ||
Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia | Q39332231 | ||
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia. | Q39590044 | ||
Morphological and biochemical patterns in skeletal muscle apoptosis | Q39772858 | ||
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients | Q39881982 | ||
Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells | Q39947772 | ||
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin | Q40059172 | ||
Sphingosine kinase 1 is up-regulated in colon carcinogenesis | Q40345686 | ||
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines | Q40384186 | ||
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. | Q40883173 | ||
Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells | Q41849432 | ||
In vitro anti-leukaemia activity of sphingosine kinase inhibitor | Q42445577 | ||
mTOR, AMBRA1, and autophagy: an intricate relationship | Q42790841 | ||
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis | Q42799996 | ||
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer | Q44501429 | ||
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling | Q46085978 | ||
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue | Q46516547 | ||
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism | Q46666883 | ||
Inhibition of MAP kinase by sphingosine and its methylated derivative, N,N-dimethylsphingosine | Q47764761 | ||
Acute lymphoblastic leukaemia | Q56722375 | ||
Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways | Q56998115 | ||
P433 | issue | 17 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | leukemia | Q29496 |
autophagy | Q288322 | ||
lymphoblastic leukemia | Q18553852 | ||
T-cell acute lymphoblastic leukemia | Q55949881 | ||
P1104 | number of pages | 16 | |
P304 | page(s) | 7886-7901 | |
P577 | publication date | 2014-09-01 | |
P1433 | published in | Oncotarget | Q1573155 |
P1476 | title | Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics | |
P478 | volume | 5 |
Q39929088 | Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach |
Q36679531 | Intracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular Targets |
Q56387433 | Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era |
Q35833018 | PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors. |
Q36544596 | Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches. |
Q38495744 | Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies |
Q30853652 | SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production |
Q42343101 | Sphingosine kinase 2 and multiple myeloma |
Q50021960 | Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice |
Q28552969 | Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation |
Q28066270 | Targeting autophagy to sensitive glioma to temozolomide treatment |
Q90651738 | Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies |
Q89552648 | The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias |
Q38909416 | Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. |
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