scholarly article | Q13442814 |
P50 | author | Ilaria Iacobucci | Q64685191 |
Giovanni Martinelli | Q66370881 | ||
Pier Luigi Tazzari | Q86958213 | ||
P2093 | author name string | James A McCubrey | |
Annalisa Lonetti | |||
Francesca Ricci | |||
Alberto M Martelli | |||
Sergio Amadori | |||
Mirella Falconi | |||
Andrea Ognibene | |||
Daniela Bressanin | |||
Francesca Chiarini | |||
Pasqualepaolo Pagliaro | |||
Alessandra Cappellini | |||
Ester Orsini | |||
Gabriella Teti | |||
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FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism | Q35169597 | ||
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Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 | Q35640339 | ||
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health | Q35679353 | ||
Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK. | Q36050696 | ||
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance | Q36092560 | ||
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Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. | Q37865381 | ||
Clonal evolution of acute leukemia genomes | Q37986426 | ||
Clofarabine in pediatric acute leukemia: current findings and issues | Q37987061 | ||
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Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a | Q39328413 | ||
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia. | Q39344848 | ||
Autophagy is required for the activation of NFκB. | Q39424847 | ||
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. | Q39434450 | ||
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications. | Q39463725 | ||
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia. | Q39590044 | ||
Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors | Q39600915 | ||
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia. | Q39650704 | ||
Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia. | Q39653305 | ||
Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM. | Q40707620 | ||
Treatment of acute myeloid leukemia | Q41893399 | ||
Oct1 is required for mTOR-induced G1 cell cycle arrest via the control of p27(Kip1) expression | Q42863180 | ||
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways | Q42871137 | ||
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. | Q43741513 | ||
Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. | Q46003222 | ||
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia. | Q50506558 | ||
Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma. | Q52628427 | ||
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. | Q53526869 | ||
Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107) | Q82498689 | ||
Novel agents in acute myeloid leukemia | Q84831447 | ||
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | leukemia | Q29496 |
acute myeloid leukemia | Q264118 | ||
allosteric inhibitor | Q70361704 | ||
P304 | page(s) | 1615-1628 | |
P577 | publication date | 2012-12-01 | |
P1433 | published in | Oncotarget | Q1573155 |
P1476 | title | A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia | |
P478 | volume | 3 |
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Q37132224 | Pharmacological targeting of the PI3K/mTOR pathway alters the release of angioregulatory mediators both from primary human acute myeloid leukemia cells and their neighboring stromal cells |
Q37132233 | Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia |
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