A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia

scientific article published on December 2012

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.762
P932PMC publication ID3681499
P698PubMed publication ID23271044
P5875ResearchGate publication ID233999241

P50authorIlaria IacobucciQ64685191
Giovanni MartinelliQ66370881
Pier Luigi TazzariQ86958213
P2093author name stringJames A McCubrey
Annalisa Lonetti
Francesca Ricci
Alberto M Martelli
Sergio Amadori
Mirella Falconi
Andrea Ognibene
Daniela Bressanin
Francesca Chiarini
Pasqualepaolo Pagliaro
Alessandra Cappellini
Ester Orsini
Gabriella Teti
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AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.Q39463725
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.Q39590044
Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitorsQ39600915
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.Q39650704
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Oct1 is required for mTOR-induced G1 cell cycle arrest via the control of p27(Kip1) expressionQ42863180
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathwaysQ42871137
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.Q43741513
Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.Q46003222
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.Q50506558
Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma.Q52628427
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.Q53526869
Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107)Q82498689
Novel agents in acute myeloid leukemiaQ84831447
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
acute myeloid leukemiaQ264118
allosteric inhibitorQ70361704
P304page(s)1615-1628
P577publication date2012-12-01
P1433published inOncotargetQ1573155
P1476titleA combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia
P478volume3

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