Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells

scientific article

Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.2456613
P698PubMed publication ID2456613

P2093author name stringLópez-López JR
López-Barneo J
González C
Ureña J
P433issue4865
P407language of work or nameEnglishQ1860
P921main subjectchemoreceptor cellQ1069641
P304page(s)580-582
P577publication date1988-07-01
P1433published inScienceQ192864
P1476titleChemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells
P478volume241

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cites work (P2860)
Q38313197A case of serendipity*.
Q47818667A century of control of breathing
Q36436833A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus
Q41826460A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing
Q57129025A1899, PK-THPP, ML365, and Doxapram inhibit endogenous TASK channels and excite calcium signaling in carotid body type-1 cells
Q36482354AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells
Q36494836AMP-activated protein kinase underpins hypoxic pulmonary vasoconstriction and carotid body excitation by hypoxia in mammals
Q61855668AQP1 mediates water transport in the carotid body
Q52865249Acid-evoked quantal catecholamine secretion from rat phaeochromocytoma cells and its interaction with hypoxia-evoked secretion.
Q48592154Acid-sensing by carotid body is inhibited by blockers of voltage-sensitive Ca2+ channels
Q38114319Acid-sensing ion channels under hypoxia
Q28570875Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction
Q36052206Acute hypoxia differentially regulates K(+) channels. Implications with respect to cardiac arrhythmia.
Q45133170Acute oxygen sensing by the carotid body: from mitochondria to plasma membrane
Q41839871Acute oxygen sensing in heme oxygenase-2 null mice
Q28362891Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors
Q46246243Acute oxygen-sensing by the carotid body: a rattlebag of molecular mechanisms.
Q33577287Acute oxygen-sensing mechanisms
Q51472436Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells.
Q71889767Anoxic disturbance of the isolated respiratory network of neonatal rats
Q48467234Arachidonic acid inhibits both K+ and Ca2+ currents in isolated type I cells of the rat carotid body
Q41667713Are oxygen dependent K+ channels essential for carotid body chemo-transduction?
Q47822545Assessment of oxygen sensing by model airway and arterial chemoreceptors.
Q43562297Barium-stimulated chemosensory activity may not reflect inhibition of background voltage-insensitive K+ channels in the rat carotid body
Q48643488CO interact with intracellular [H+] with and without CO2-HCO3- in the cat carotid chemosensory discharge
Q44070450CO-induced K(+) currents in rat glomus cells are insensitive to light unlike carotid body neural discharge and Vo(O(2)).
Q89087713Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia
Q57073001Carotid Body Type-I Cells Under Chronic Sustained Hypoxia: Focus on Metabolism and Membrane Excitability
Q42469525Carotid body chemosensory responses in mice deficient of TASK channels.
Q56425066Carotid body chemotransduction gets the human touch
Q38587534Carotid body oxygen sensing and adaptation to hypoxia.
Q34749311Carotid body thin slices: responses of glomus cells to hypoxia and K(+)-channel blockers.
Q79429327Catecholamine secretion from rat foetal adrenal chromaffin cells and hypoxia sensitivity
Q37886149Cell-based therapies for Parkinson's disease
Q34972696Cellular distribution of oxygen sensor candidates-oxidases, cytochromes, K+-channels--in the carotid body
Q34020064Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels
Q33910357Cellular oxygen sensing by mitochondria: old questions, new insight
Q51478081Characteristics of 5-HT-containing chemoreceptor cells of the chicken aortic body.
Q43822285Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice
Q46307478Characterization of ion channels and O2 sensitivity in gill neuroepithelial cells of the anoxia-tolerant goldfish (Carassius auratus).
Q44807559Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing
Q33755654Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR.
Q52866358Chronic hypoxia enhances the secretory response of rat phaeochromocytoma cells to acute hypoxia.
Q52050020Comparative gene expression profile of mouse carotid body and adrenal medulla under physiological hypoxia.
Q67843130Contrasting effects of HEPES vs HCO3−-buffered media on whole-cell currents in cultured chemoreceptors of the rat carotid body
Q77772799Contribution of Ca2+-activated K+ channels and non-selective cation channels to membrane potential of pulmonary arterial smooth muscle cells of the rabbit
Q96302126Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?
Q42467417Cyclic AMP Modulates Differentially the Release of Dopamine Induced by Hypoxia and Other Stimuli and Increases Dopamine Synthesis in the Rabbit Carotid Body
Q33251267Detecting acute changes in oxygen: will the real sensor please stand up?
Q52218085Developmental changes in hypoxia-induced catecholamine release from rat carotid body, in vitro.
Q34017542Developmental influences on carotid body responses to hypoxia
Q52196685Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells.
Q42453233Differential regulation of the slow and rapid components of guinea-pig cardiac delayed rectifier K+ channels by hypoxia
Q51290917Distribution and morphology of cholinergic cells in the branchial epithelium of zebrafish (Danio rerio).
Q34657662Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease.
Q47797805Down regulation of Kv3.4 channels by chronic hypoxia increases acute oxygen sensitivity in rabbit carotid body.
Q56426544Effect of lowered extracellular pH on Ca2(+)-dependent K+ currents in type I cells from the neonatal rat carotid body
Q48215229Effect of the removal of extracellular Ca2+ on the response of cytosolic concentrations of Ca2+ to ouabain in carotid body glomus cells of adult rabbits
Q43804966Effects of D600 on hypoxic suppression of K+ currents in isolated type I carotid body cells of the neonatal rat.
Q41108722Effects of almitrine on the release of catecholamines from the rabbit carotid body in vitro
Q41652354Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body
Q42474872Effects of fluoride and cholera and pertussis toxins on sensory transduction in the carotid body
Q54249839Effects of hypoxia and dithionite on catecholamine release from isolated type I cells of the rat carotid body.
Q44400667Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells.
Q37720685Effects of modulators of AMP-activated protein kinase on TASK-1/3 and intracellular Ca(2+) concentration in rat carotid body glomus cells
Q44889096Effects of reducing agents on glutathione metabolism and the function of carotid body chemoreceptor cells
Q92687705Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels
Q48460634Electrophysiological and immunocytological demonstration of cell-type specific responses to hypoxia in the adult cat carotid body
Q43740085Electrophysiological responses of dissociated type I cells of the rabbit carotid body to cyanide
Q42646423Evidence for a PO2-sensitive K+ channel in the type-I cell of the rabbit carotid body
Q33708212Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
Q72841171Exploration of the pulmonary circulation. Festschrift to Professor Donald Heath
Q38214597Fernando de Castro and the discovery of the arterial chemoreceptors
Q31035236Functional genomics approach to hypoxia signaling
Q26999511Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body
Q44176984Graded response of K+ current, membrane potential, and [Ca2+]i to hypoxia in pulmonary arterial smooth muscle
Q41822934Guinea Pig Oxygen-Sensing and Carotid Body Functional Properties
Q42484807HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body
Q26862091HIF hydroxylase pathways in cardiovascular physiology and medicine
Q37606472Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles
Q56425285Hetero or homo, hypoxia has them all
Q28363118Heterogeneity of neuronal nicotinic acetylcholine receptors in 5-HT-containing chemoreceptor cells of the chicken aorta
Q46316704Hypoxia Sensing in Plants: On a Quest for Ion Channels as Putative Oxygen Sensors.
Q37240454Hypoxia and N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate, but not nerve growth factor, induce Na+ channels and hypertrophy in chromaffin-like arterial chemoreceptors
Q36642713Hypoxia and lipid signaling
Q33789011Hypoxia and the pulmonary circulation
Q72482110Hypoxia increases the activity of Ca(2+)-sensitive K+ channels in cat cerebral arterial muscle cell membranes
Q48430230Hypoxia induced by Na2S2O4 increases [Na+]i in mouse glomus cells, an effect depressed by cobalt. Experiments with Na+-selective microelectrodes and voltage-clamping
Q35841492Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells.
Q52868122Hypoxia inhibits the recombinant alpha 1C subunit of the human cardiac L-type Ca2+ channel.
Q36356591Hypoxia-induced changes in neuronal network properties.
Q34979263Hypoxia. 4. Hypoxia and ion channel function
Q53910260Hypoxic excitation in neurons cultured from the rostral ventrolateral medulla of the neonatal rat.
Q33752519Hypoxic pulmonary vasoconstriction
Q56426516Hypoxic suppression of K+ currents in type I carotid body cells: Selective effect on the Ca2+-activated K+ current
Q33924387Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO
Q30664150Identification of hypoxia-responsive genes in a dopaminergic cell line by subtractive cDNA libraries and microarray analysis
Q50460188Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body
Q34769890Inhibition of 15-lipoxygenase (15-LOX) reverses hypoxia-induced down-regulation of potassium channels Kv1.5 and Kv2.1Inhibition of 15-lipoxygenase (15-LOX) reverses hypoxia-induced down-regulation of potassium channels Kv1.5 and Kv2.1.
Q56426496Inhibition of Ca(2+)-activated K+ currents by intracellular acidosis in isolated type I cells of the neonatal rat carotid body
Q54250791Inhibition of Protein Kinases AKT and ERK1/2 Reduce the Carotid Body Chemoreceptor Response to Hypoxia in Adult Rats.
Q42476268Inhibition of [3H]catecholamine release and Ca2+ currents by prostaglandin E2 in rabbit carotid body chemoreceptor cells.
Q35756274Interactions of chemostimuli at the single cell level: studies in a model system
Q48356699Ionic currents in carotid body type I cells isolated from normoxic and chronically hypoxic adult rats
Q42976140Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body
Q44218017Ionic mechanisms for the transduction of acidic stimuli in rabbit carotid body glomus cells
Q37693239Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
Q27022670K(+) channels in O(2) sensing and postnatal development of carotid body glomus cell response to hypoxia
Q33672148K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues
Q33672131K+ currents of glomus cells and chemosensory functions of carotid body
Q47962501K+-current modulated by PO2 in type I cells in rat carotid body is not a chemosensor
Q41918102Kvbeta1.2 subunit coexpression in HEK293 cells confers O2 sensitivity to kv4.2 but not to Shaker channels
Q71490936L- and N-type Ca2+ channels in adult rat carotid body chemoreceptor type I cells
Q42777629Lessons from single-cell transcriptome analysis of oxygen-sensing cells
Q43890858Low glucose-sensing cells in the carotid body.
Q45943454MaxiK potassium channels in the function of chemoreceptor cells of the rat carotid body.
Q60182148Measurements of intracellular Ca2+ in dissociated type I cells of the rabbit carotid body
Q37222238Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus
Q40570342Methods to study oxygen sensing sodium channels
Q37779842Mitochondrial complex III: an essential component of universal oxygen sensing machinery?
Q44114353Modulation of K+ channels by hydrogen peroxide
Q28574306Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body
Q42522672Modulation of glomus cell membrane currents of intact rat carotid body
Q40981937Modulation of recombinant human cardiac L-type Ca2+ channel alpha1C subunits by redox agents and hypoxia
Q34800154Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels
Q34280464Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels
Q44067072Molecular identification of Kvalpha subunits that contribute to the oxygen-sensitive K+ current of chemoreceptor cells of the rabbit carotid body.
Q39804789Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes
Q50057458Monitoring Functional Responses to Hypoxia in Single Carotid Body Cells
Q33672142Neuroepithelial bodies as airway oxygen sensors
Q44503988Neurons sensitive to pH in slices of the rat ventral medulla oblongata
Q37723195Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors
Q38806009New perspectives on the development of muscle contractures following central motor lesions.
Q33858142O(2) deprivation inhibits Ca(2+)-activated K(+) channels via cytosolic factors in mice neocortical neurons
Q40485207O2 deprivation in the central nervous system: On mechanisms of neuronal response, differential sensitivity and injury
Q35768162O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide
Q36411174O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
Q40683406O2-sensitive K+ channels in immortalised rat chromaffin-cell-derived MAH cells.
Q34861221O2-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction
Q51925011Orthodromic spike generation from electrical stimuli in the rat carotid body: implications for the afferent spike generation process.
Q35559144Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect
Q42689683Oxygen deprivation inhibits a K+ channel independently of cytosolic factors in rat central neurons
Q27315024Oxygen regulation of breathing through an olfactory receptor activated by lactate
Q47684051Oxygen sensing and response to hypoxia by mammalian cells
Q33672162Oxygen sensing and signaling: impact on the regulation of physiologically important genes
Q47822473Oxygen sensing by human recombinant K+ channels: assessment of the use of stable cell lines.
Q73059547Oxygen sensing by ion channels
Q33939186Oxygen sensing by the carotid body chemoreceptors
Q38695841Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia.
Q59060515Oxygen sensing in airway chemoreceptors
Q35636281Oxygen sensing in neuroendocrine cells and other cell types: pheochromocytoma (PC12) cells as an experimental model
Q36246924Oxygen sensing in the body
Q37360962Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel
Q74577297Oxygen-sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth
Q35602028Oxygen-sensing neurons in the central nervous system.
Q50758448Oxygen-sensing persistent sodium channels in rat hippocampus.
Q29615332PAS domains: internal sensors of oxygen, redox potential, and light
Q51626382Participation of Na+ channels in the response of carotid body chemoreceptor cells to hypoxia.
Q37572329Peripheral chemoreceptors: function and plasticity of the carotid body
Q28206353Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia
Q52062790Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.
Q42468469Presynaptic action of adenosine on a 4-aminopyridine-sensitive current in the rat carotid body
Q72969560Properties of a transient K+ current in chemoreceptor cells of rabbit carotid body
Q52196034Properties of ionic currents from isolated adult rat carotid body chemoreceptor cells: effect of hypoxia.
Q28551511Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen
Q36769620Purines, the carotid body and respiration.
Q34455919Reactive oxygen intermediates involved in cellular regulation
Q41671501Reciprocal photolabile O2 consumption and chemoreceptor excitation by carbon monoxide in the cat carotid body: evidence for cytochrome a3 as the primary O2 sensor
Q48219530Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen.
Q28365032Redox control of oxygen sensing in the rabbit ductus arteriosus
Q39359788Redox signaling during hypoxia in mammalian cells
Q38801894Redox signaling in acute oxygen sensing
Q31885063Reduced glutathione, dithiothreitol and cytochrome P-450 inhibitors do not influence hypoxic chemosensory responses in the rat carotid body
Q28364362Reduced to oxidized glutathione ratios and oxygen sensing in calf and rabbit carotid body chemoreceptor cells
Q41752328Regulating the ventilatory pump: a splendid control system prone to fail during sleep
Q38125147Regulation of cellular gas exchange, oxygen sensing, and metabolic control
Q41131095Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia
Q35651193Regulation of oxygen sensing by ion channels.
Q42470734Release of dopamine and chemoreceptor discharge induced by low pH and high PCO2 stimulation of the cat carotid body.
Q31924129Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels
Q34790987Responding to hypoxia: lessons from a model cell line
Q60679804Responses of glomus cells to hypoxia and acidosis are uncoupled, reciprocal and linked to ASIC3 expression: selectivity of chemosensory transduction
Q68589252Responses of type I cells dissociated from the rabbit carotid body to hypoxia
Q42077261Role of MaxiK-type calcium dependent K+ channels in rat carotid body hypoxia transduction during postnatal development
Q35041018Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells
Q45140540Role of voltage-dependent calcium channels in stimulus-secretion coupling in rabbit carotid body chemoreceptor cells.
Q44355549Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
Q24674593Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium
Q34139832Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia
Q37469305Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension
Q43705299Specific actions of cyanide on membrane potential and voltage-gated ion currents in rostral ventrolateral medulla neurons in rat brainstem slices.
Q28571584Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes
Q34455923Superoxide generation of phagocytes and nonphagocytic cells
Q48456342Suppression of glomus cell K+ conductance by 4-aminopyridine is not related to [Ca2+]i, dopamine release and chemosensory discharge from carotid body
Q73901171Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurones and carotid body type 1 cells
Q40623544System-specific O2 sensitivity of the tandem pore domain K+ channel TASK-1.
Q37398806TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats
Q48486647TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body.
Q37987914Tetrodotoxin as a tool to elucidate sensory transduction mechanisms: the case for the arterial chemoreceptors of the carotid body.
Q48360938The G. L. Brown Prize Lecture. Hypoxic regulation of ion channel function and expression
Q33917451The Walter B. Cannon Memorial Award Lecture, 2009. Physiology in perspective: The wisdom of the body. In search of autonomic balance: the good, the bad, and the ugly
Q28072485The emerging role of AMPK in the regulation of breathing and oxygen supply
Q38614901The fetal brain sparing response to hypoxia: physiological mechanisms.
Q37812720The interactions between locomotion and respiration
Q34756661The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies
Q32025747The molecular basis of O2-sensing and hypoxia tolerance in pheochromocytoma cells
Q37407129The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy.
Q43787954The presence of CO2/HCO3− is essential for hypoxic chemotransduction in the in vivo perfused carotid body
Q42462608The role of cyclic AMP in chemoreception in the rabbit caroid body
Q41495146The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma.
Q74244917The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions
Q37731210The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis
Q40611691Tissue Dynamics of the Carotid Body Under Chronic Hypoxia: A Computational Study.
Q40435151Transduction of chemostimuli by the type I carotid body cell
Q48831462Two types of voltage-gated K channels in carotid body cells of adult cats
Q51390568Viral gene transfer of dominant-negative Kv4 construct suppresses an O2-sensitive K+ current in chemoreceptor cells.
Q43913673Whole-cell and perforated-patch recordings from O2-sensitive rat carotid body cells grown in short- and long-term culture

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