Ubiquitin proteasome pathway: implications and advances in cancer therapy

scientific article

Ubiquitin proteasome pathway: implications and advances in cancer therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0960-7404(01)00018-4
P698PubMed publication ID11719028

P2093author name stringShah SA
Callery MP
Potter MW
P2860cites workRange of sizes of peptide products generated during degradation of different proteins by archaeal proteasomesQ74088744
Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53Q77764263
Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasomeQ77907913
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse CellsQ24609948
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradationQ24650561
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosisQ24656114
WAF1, a potential mediator of p53 tumor suppressionQ27861121
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiaeQ27939221
Cyclin is degraded by the ubiquitin pathwayQ28131704
Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2Q28237519
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I moleculesQ28248180
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystinQ28300614
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathwayQ28615706
Cancer cell cyclesQ29547756
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursQ29618396
The ubiquitin systemQ29618565
The ubiquitin-proteasome proteolytic pathwayQ29618638
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationQ29618715
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
Proteasome inhibitors: valuable new tools for cell biologistsQ29620573
Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells.Q31107812
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoterQ33559371
26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancerQ33950784
Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressQ33997846
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancerQ34415244
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.Q34415250
Catalysis by a multiprotein IkappaB kinase complexQ34743658
DNA damage induces phosphorylation of the amino terminus of p53Q35199554
Apoptosis induced by anticancer drugsQ35233723
Proteasomes play an essential role in thymocyte apoptosisQ35904377
Activation of the cell death program by inhibition of proteasome functionQ35964722
Control of programmed cyclin destruction in a cell-free systemQ36221788
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB controlQ36580820
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathwayQ36648425
The mechanism and functions of ATP-dependent proteases in bacterial and animal cellsQ36736334
Degradation of nuclear oncoproteins by the ubiquitin system in vitroQ37361143
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancerQ37376029
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa BQ37649750
The multicatalytic proteinase complex, a major extralysosomal proteolytic systemQ37901108
The role of cyclin synthesis, modification and destruction in the control of cell division.Q38262781
Dominoes and clocks: the union of two views of the cell cycleQ38718174
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cellsQ39795545
Apoptosis in cancer therapy: crossing the thresholdQ40694262
Apoptosis. Its significance in cancer and cancer therapyQ40739570
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblastsQ40979308
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.Q41076164
Enhancement of CPP32-like activity in the TNF-treated U937 cells by the proteasome inhibitorsQ41185868
Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasomeQ41197961
Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactoneQ41213327
Cell and environment interactions in tumor microregions: the multicell spheroid modelQ41280817
The ubiquitin-mediated proteolytic pathway as a therapeutic areaQ41340821
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitinationQ41589996
Apoptosis induction resulting from proteasome inhibitionQ42079940
Apoptosis-inducing levels of UV radiation and proteasome inhibitors produce opposite effects on p21(WAF1) in human melanoma cellsQ42487557
Potent and selective inhibitors of the proteasome: dipeptidyl boronic acidsQ42537232
Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.Q43584710
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.Q45993768
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acidsQ48331723
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.Q52973572
alpha-Aminoboronic acid derivatives: effective inhibitors of aminopeptidasesQ68871372
Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cellsQ70114212
Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cellsQ70881911
Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitorsQ73011657
p21WAF1 expression is associated with improved survival after adjuvant chemoradiation for pancreatic cancerQ73030013
Peptidyl aldehyde inhibitors of proteasome induce apoptosis rapidly in mouse lymphoma RVC cellsQ73303188
Detailed analysis of cell cycle kinetics upon proteasome inhibitionQ73508420
P433issue1-2
P921main subjectubiquitin-proteasome systemQ47175589
P304page(s)43-52
P577publication date2001-07-01
P1433published inSurgical OncologyQ14421678
P1476titleUbiquitin proteasome pathway: implications and advances in cancer therapy
P478volume10

Reverse relations

cites work (P2860)
Q4419547915-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells
Q44380190A short, stereocontrolled, and practical synthesis of alpha-methylomuralide, a potent inhibitor of proteasome function
Q39652073Antitrypanosomal activities of proteasome inhibitors
Q33960631Cachexia: a therapeutic approach beyond cytokine antagonism
Q40631657Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.
Q37962590Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors
Q45784186Evidence for the Critical Roles of NF-κB p65 and Specificity Proteins in the Apoptosis-Inducing Activity of Proteasome Inhibitors in Leukemia Cells
Q40502949Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells
Q37314468Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132
Q35038788Heat shock protein and proteasome targeting agents
Q35548615Immunoproteasomes and immunosenescence
Q37480580MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype
Q36642830MG132, a proteasome inhibitor, induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion
Q24310815Mapping and structural dissection of human 20 S proteasome using proteomic approaches
Q54602513Mitogen-activated protein kinase inhibitors differently affect the growth inhibition and death of a proteasome inhibitor, MG132-treated human pulmonary fibroblast cells.
Q38961037Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells.
Q44428903Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.
Q34633196Regulation of apoptosis by the ubiquitin and proteasome pathway.
Q37188091Role of proteasomes in cellular regulation
Q40114381Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells
Q36897340Targeted therapies in small-cell lung cancer
Q36305395The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis
Q39693556Treatment with p38 inhibitor intensifies the death of MG132-treated As4.1 juxtaglomerular cells via the enhancement of GSH depletion
Q42176007WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells

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