Structure of mammalian eIF3 in the context of the 43S preinitiation complex

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Structure of mammalian eIF3 in the context of the 43S preinitiation complex is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1001312163
P356DOI10.1038/NATURE14891
P932PMC publication ID4719162
P698PubMed publication ID26344199
P5875ResearchGate publication ID281588266

P50authorJoachim FrankQ28833112
P2093author name stringAmedee des Georges
Christopher U T Hellen
Tatyana V Pestova
Vidya Dhote
Yaser Hashem
Lauriane Kuhn
P2860cites workStructure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29Q24293558
The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitroQ24302384
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3Q24309617
Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexesQ24310392
Reconstitution reveals the functional core of mammalian eIF3Q24312641
The InterPro protein families database: the classification resource after 15 yearsQ24465922
Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assemblyQ24618222
PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexesQ24815484
'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)Q26852951
Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunitQ27643432
Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosaQ27643886
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosomeQ27676277
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.Q27677990
Structure of the ternary initiation complex aIF2-GDPNP-methionylated initiator tRNAQ27678199
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunitQ27680505
Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexesQ27681329
Structures of the human and Drosophila 80S ribosomeQ27684535
Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lidQ27685325
Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunitQ27690100
Crystal structure of the human COP9 signalosomeQ27694578
Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complexQ27697933
VMD: visual molecular dynamicsQ27860554
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fieldsQ27860560
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modelingQ27860614
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Probability-based protein identification by searching sequence databases using mass spectrometry dataQ27860736
Molecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complexQ27934341
The RNA recognition motif of eukaryotic translation initiation factor 3g (eIF3g) is required for resumption of scanning of posttermination ribosomes for reinitiation on GCN4 and together with eIF3i stimulates linear scanningQ27934575
Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosomeQ28117731
Complete subunit architecture of the proteasome regulatory particleQ28257212
Crystal structure of human eIF3k, the first structure of eIF3 subunitsQ28265251
Cryo-electron microscopy of vitrified specimensQ28288841
The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thalianaQ28542463
Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors.Q35040962
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysisQ35533889
The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo.Q35964439
Translation initiation: structures, mechanisms and evolutionQ36272181
Architecture of human translation initiation factor 3.Q37086118
Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex.Q37201229
Structural biology of the PCI-protein fold.Q38041924
Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regionsQ40676456
Automated particle picking for low-contrast macromolecules in cryo-electron microscopyQ40879471
Quantifying the local resolution of cryo-EM density mapsQ41609859
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopyQ42103385
Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.Q42152342
Biophysical and structural characterization of the recombinant human eIF3L.Q42278698
CHARMM: A program for macromolecular energy, minimization, and dynamics calculationsQ53340989
Direct localization of the tRNA--anticodon interaction site on the Escherichia coli 30 S ribosomal subunit by electron microscopy and computerized image averagingQ70236905
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopyQ29547579
RELION: implementation of a Bayesian approach to cryo-EM structure determinationQ29547673
Automated molecular microscopy: the new Leginon systemQ29614290
CDD: NCBI's conserved domain databaseQ29615740
Flexible fitting of atomic structures into electron microscopy maps using molecular dynamicsQ29616808
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunitQ33246406
Preparation of macromolecular complexes for cryo-electron microscopyQ33310283
Bioinformatics strategies in life sciences: from data processing and data warehousing to biological knowledge extractionQ33589730
The Saccharomyces cerevisiae HCR1 gene encoding a homologue of the p35 subunit of human translation initiation factor 3 (eIF3) is a high copy suppressor of a temperature-sensitive mutation in the Rpg1p subunit of yeast eIF3.Q33874241
Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cellsQ34056518
Target-decoy search strategy for mass spectrometry-based proteomicsQ34070061
The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selectionQ34091806
The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.Q34119657
Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29.Q34168375
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3).Q34237617
Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAsQ34304805
Small ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunitQ34336340
eIF3: a versatile scaffold for translation initiation complexesQ34558903
P433issue7570
P407language of work or nameEnglishQ1860
P304page(s)491-495
P577publication date2015-09-07
P1433published inNatureQ180445
P1476titleStructure of mammalian eIF3 in the context of the 43S preinitiation complex
P478volume525

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