Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

scientific article published on 30 November 2018

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.39273
P932PMC publication ID6298780
P698PubMed publication ID30475211

P50authorJosé L. LlácerQ38318921
Jon R. LorschQ42129473
Adesh K SainiQ56670325
Jagpreet Singh NandaQ93365301
P2093author name stringRakesh Kumar
V Ramakrishnan
Alan G Hinnebusch
Tanweer Hussain
Sukhvir Kaur
Yuliya Gordiyenko
P2860cites workStructure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29Q24293558
Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5Q24299338
Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexesQ24310392
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivoQ24540322
Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codonsQ24631083
MolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1Q27666453
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.Q27677990
The initiation of mammalian protein synthesis and mRNA scanning mechanismQ27679159
Molecular architecture of a eukaryotic translational initiation complexQ27680550
Structure of the Yeast Mitochondrial Large Ribosomal SubunitQ27682617
Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the RibosomeQ27683626
Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNAQ27694629
Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complexQ27697933
eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon RecognitionQ27715999
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
EMAN2: an extensible image processing suite for electron microscopyQ27861052
Features and development of CootQ27861079
A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codonQ27932344
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosomeQ27934357
The RNA recognition motif of eukaryotic translation initiation factor 3g (eIF3g) is required for resumption of scanning of posttermination ribosomes for reinitiation on GCN4 and together with eIF3i stimulates linear scanningQ27934575
Eukaryotic translation initiation factor 5 functions as a GTPase-activating proteinQ27934712
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiaeQ27935355
Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.Q27935870
The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA.Q27936240
Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domainsQ27936401
Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selectionQ27940184
Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particlesQ28044576
Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factorsQ28305102
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopyQ29547579
RELION: implementation of a Bayesian approach to cryo-EM structure determinationQ29547673
Prevention of overfitting in cryo-EM structure determinationQ29614287
Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein.Q31882295
Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complexQ33993880
Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complexQ34115417
The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.Q34119657
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.Q34155548
Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)Q34241370
Structural changes enable start codon recognition by the eukaryotic translation initiation complexQ34440678
Structure of mammalian eIF3 in the context of the 43S preinitiation complexQ34492793
eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanningQ34510080
Crystal structure of the C-terminal domain of S.cerevisiae eIF5.Q34514211
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivoQ34628703
New universal rules of eukaryotic translation initiation fidelityQ34845179
Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation ComplexQ35948019
The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2βQ36106749
Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex.Q36174741
Sampling the conformational space of the catalytic subunit of human γ-secretaseQ36479662
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complexQ36636060
Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiaeQ36692684
β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivoQ37189587
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiationQ37441324
Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selectionQ37574552
The scanning mechanism of eukaryotic translation initiationQ38185457
Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysisQ38667758
Eukaryotic aspects of translation initiation brought into focusQ38764186
Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation InitiationQ39262099
Large-Scale Movements of IF3 and tRNA during Bacterial Translation InitiationQ41189047
Gctf: Real-time CTF determination and correctionQ41603517
Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructionsQ41606440
Semi-automated selection of cryo-EM particles in RELION-1.3.Q41606707
Quantifying the local resolution of cryo-EM density mapsQ41609859
Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codonsQ41750015
Global translational impacts of the loss of the tRNA modification t6A in yeast.Q41833611
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiationQ46772123
Reconstitution of yeast translation initiation.Q46968946
Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle.Q47234689
eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast.Q47252148
eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex.Q52318693
Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptidesQ72959521
P407language of work or nameEnglishQ1860
P577publication date2018-11-30
P1433published ineLifeQ2000008
P1476titleTranslational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
P478volume7

Reverse relations

cites work (P2860)
Q92167429Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively
Q91769907Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes
Q92730638Control of Translation at the Initiation Phase During Glucose Starvation in Yeast
Q89583429Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation
Q90644673Global analysis of protein synthesis in Flavobacterium johnsoniae reveals the use of Kozak-like sequences in diverse bacteria
Q92406628Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation
Q89533150Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom
Q64986003Structural basis for the inhibition of translation through eIF2α phosphorylation.
Q100464114Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
Q98944748Structure of a human 48S translational initiation complex