| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.MOLMED.2004.08.005 |
| P8608 | Fatcat ID | release_qvutajmr65amtfhmm4v767xrpi |
| P698 | PubMed publication ID | 15464450 |
| P2093 | author name string | Jay L Hess | |
| P433 | issue | 10 | |
| P921 | main subject | leukemia | Q29496 |
| P304 | page(s) | 500-507 | |
| P577 | publication date | 2004-10-01 | |
| P1433 | published in | Trends in Molecular Medicine | Q15265842 |
| P1476 | title | MLL: a histone methyltransferase disrupted in leukemia | |
| P478 | volume | 10 |
| Q38989732 | A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia. |
| Q37212691 | A single center analysis of nucleophosmin in acute myeloid leukemia: value of combining immunohistochemistry with molecular mutation analysis |
| Q33737465 | ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot |
| Q37364509 | Acute myeloid leukemia: potential for new therapeutic approaches targeting mRNA translation pathways |
| Q33303448 | Alu recombination-mediated structural deletions in the chimpanzee genome |
| Q42216959 | Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction |
| Q36920160 | Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol |
| Q33630989 | Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo |
| Q35625061 | Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer. |
| Q36164751 | Causes and consequences of DNA hypomethylation in human cancer |
| Q36436582 | Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells |
| Q36419977 | Chromatin control and cancer-drug discovery: realizing the promise |
| Q34601806 | Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects |
| Q35128590 | Chromosomal translocations involving the MLL gene: molecular mechanisms |
| Q28301344 | Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review |
| Q28476656 | Co-regulation of histone-modifying enzymes in cancer |
| Q50477441 | Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. |
| Q24605342 | Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers |
| Q24336563 | Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells |
| Q36903197 | DNA topoisomerase II, genotoxicity, and cancer |
| Q35083276 | DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis |
| Q38852979 | Deregulation of the HOXA9/MEIS1 axis in acute leukemia |
| Q41449642 | Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases |
| Q36970197 | Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators. |
| Q92140281 | Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core |
| Q57773815 | Discovery of Potent 2-Aryl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design |
| Q28589003 | Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4. |
| Q24652323 | Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin |
| Q27021783 | Diverse functions of PHD fingers of the MLL/KMT2 subfamily |
| Q33794291 | Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal |
| Q21134949 | Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression |
| Q46120564 | Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle. |
| Q24646412 | E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases |
| Q34700307 | Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications |
| Q41659307 | Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo. |
| Q39950903 | Epigenetic dysregulation in cancer |
| Q37087598 | Epigenetic gene regulation in cancer |
| Q37189326 | Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming. |
| Q37976256 | Epigenetic regulation in RCC: opportunities for therapeutic intervention? |
| Q36185227 | Epigenetic regulation of cardiac development and function by polycomb group and trithorax group proteins |
| Q37802749 | Epigenetic regulations in hematopoietic Hox code. |
| Q90569909 | Epigenetic synthetic lethality approaches in cancer therapy |
| Q38019955 | Epigenetics and blood disorders |
| Q38289023 | Epigenetics in T-cell acute lymphoblastic leukemia |
| Q38192027 | Epigenetics: the language of the cell? |
| Q28083951 | Epigenome-based personalized medicine in human cancer |
| Q26823403 | Epigenomics of leukemia: from mechanisms to therapeutic applications |
| Q33813024 | Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia |
| Q28259744 | Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer |
| Q39937420 | Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. |
| Q35127065 | HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment |
| Q35953687 | Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes |
| Q27681486 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction |
| Q39287415 | Histone Demethylase Gene PHF2 Is Mutated in Gastric and Colorectal Cancers |
| Q34546055 | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex |
| Q36438203 | Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo |
| Q34861446 | Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression |
| Q34764674 | Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer |
| Q35216079 | Histone modifiers in cancer: friends or foes? |
| Q35025091 | Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations |
| Q37865973 | How does DNA break during chromosomal translocations? |
| Q93344389 | IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation |
| Q35849140 | Increased risk for distant metastasis in patients with familial early-stage breast cancer and high EZH2 expression |
| Q28513902 | Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia |
| Q38740496 | Inhibitors of Protein Methyltransferases and Demethylases. |
| Q80726251 | Interaction of MLL amino terminal sequences with menin is required for transformation |
| Q64925832 | Isolation of MLL1 Inhibitory RNA Aptamers. |
| Q39004536 | KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis |
| Q45873757 | LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis |
| Q51205193 | Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera. |
| Q34078397 | MLL associates specifically with a subset of transcriptionally active target genes |
| Q36533425 | MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo |
| Q33694927 | MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. |
| Q37895709 | MLL-SEPTIN gene fusions in hematological malignancies |
| Q45158790 | MLL-TET1 fusion protein promotes immortalization of myeloid progenitor cells and leukemia development |
| Q37100715 | MLL5 contributes to hematopoietic stem cell fitness and homeostasis |
| Q38188051 | Mechanisms of oncogenic chromosomal translocations |
| Q40130350 | Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia |
| Q24337658 | Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors |
| Q37217351 | Menin critically links MLL proteins with LEDGF on cancer-associated target genes |
| Q92120203 | Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia |
| Q37109336 | Menin regulates the function of hematopoietic stem cells and lymphoid progenitors |
| Q30425903 | Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia |
| Q46626956 | Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human |
| Q28471927 | Misguided transcriptional elongation causes mixed lineage leukemia |
| Q42234071 | Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo |
| Q36929031 | Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1) |
| Q43239544 | Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13. |
| Q37710711 | Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. |
| Q43285195 | Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation |
| Q33947080 | Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis |
| Q27661492 | Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain |
| Q38161393 | Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis |
| Q35183855 | Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program |
| Q39152206 | NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. |
| Q46277256 | NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. |
| Q34543988 | New nuclear markers and exploration of the relationships among Serraniformes (Acanthomorpha, Teleostei): the importance of working at multiple scales |
| Q47221339 | Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries |
| Q64242611 | Non-acute promyelocytic leukemia variant, acute myeloid leukemia with translocation (11;17) |
| Q36771895 | Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing |
| Q37356131 | P-TEFb- the final frontier |
| Q40330608 | P210 Bcr-abl tyrosine kinase interaction with histone deacetylase 1 modifies histone H4 acetylation and chromatin structure of chronic myeloid leukaemia haematopoietic progenitors |
| Q40843669 | PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER |
| Q26995208 | Partners in crime: The role of tandem modules in gene transcription |
| Q92053247 | Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers |
| Q42694670 | Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia |
| Q35557914 | Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo |
| Q33966907 | Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry |
| Q34271089 | Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod. |
| Q24305335 | Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF |
| Q27678800 | Potent inhibition of DOT1L as treatment of MLL-fusion leukemia |
| Q38946966 | Preclinical Pharmacokinetics and Pharmacodynamics of Pinometostat (EPZ-5676), a First-in-Class, Small Molecule S-Adenosyl Methionine Competitive Inhibitor of DOT1L. |
| Q24319024 | Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression |
| Q37962596 | Promises and challenges of anticancer drugs that target the epigenome |
| Q27703522 | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) |
| Q33901300 | Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms. |
| Q35041289 | Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways |
| Q37644035 | Regulating the leukaemia stem cell |
| Q24296408 | Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8 |
| Q36180432 | Regulation of IL-20 Expression by Estradiol through KMT2B-Mediated Epigenetic Modification |
| Q38189284 | Regulatory non-coding RNAs: revolutionizing the RNA world |
| Q59797734 | Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma |
| Q42185555 | Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. |
| Q24315937 | Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases |
| Q28082027 | Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets |
| Q36138014 | Roles of a trithorax group gene, MLL, in hematopoiesis |
| Q41179648 | SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation |
| Q36126134 | Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor |
| Q35135783 | Selective inhibitors of protein methyltransferases |
| Q33716402 | Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. |
| Q24324784 | Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks |
| Q24310492 | Structural basis of the recognition of a methylated histone tail by JMJD2A |
| Q27671806 | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia |
| Q91933011 | Super-enhancers: critical roles and therapeutic targets in hematologic malignancies |
| Q26746038 | Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy |
| Q35687836 | Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? |
| Q47159993 | The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability |
| Q38076474 | The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis |
| Q24319075 | The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis |
| Q37001995 | The PHD fingers of MLL block MLL fusion protein-mediated transformation |
| Q35575274 | The contribution of alu elements to mutagenic DNA double-strand break repair |
| Q37897061 | The diverse functions of Dot1 and H3K79 methylation. |
| Q28594155 | The histone methyltransferase MLL1 permits the oscillation of circadian gene expression |
| Q40202913 | The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling |
| Q35222486 | The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin |
| Q36052947 | The pathogenesis of mixed-lineage leukemia |
| Q36628931 | The role of CALM-AF10 gene fusion in acute leukemia |
| Q34649133 | The role of genetics in the establishment and maintenance of the epigenome. |
| Q37571931 | The role of the double bromodomain-containing BET genes during mammalian spermatogenesis |
| Q39901831 | Therapy-related pro-B cell acute lymphoblastic leukemia: report of two patients with MLL amplification |
| Q37652882 | Topoisomerase II and leukemia |
| Q37863271 | Transcriptional and epigenetic networks in haematological malignancy |
| Q37806625 | Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences |
| Q33969764 | Zebrafish mll gene is essential for hematopoiesis |
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