| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2005PNAS..10214765M |
| P356 | DOI | 10.1073/PNAS.0503630102 |
| P932 | PMC publication ID | 1253553 |
| P698 | PubMed publication ID | 16199523 |
| P5875 | ResearchGate publication ID | 7564764 |
| P50 | author | Thomas A Milne | Q42384669 |
| P2093 | author name string | Robert G Roeder | |
| Jay L Hess | |||
| Hugh W Brock | |||
| Yali Dou | |||
| Mary Ellen Martin | |||
| P2860 | cites work | Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | Q24297027 |
| Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus | Q24313196 | ||
| Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 | Q24336747 | ||
| Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias | Q70905237 | ||
| Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality | Q73787705 | ||
| Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny | Q77583284 | ||
| Global and Hox-specific roles for the MLL1 methyltransferase | Q24529562 | ||
| Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization | Q24540662 | ||
| MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein | Q24550988 | ||
| Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization | Q24603527 | ||
| The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex | Q24624687 | ||
| Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice | Q24651171 | ||
| MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein | Q24679773 | ||
| The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation | Q27930884 | ||
| Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast | Q27931860 | ||
| A homeotic mutation in the trithorax SET domain impedes histone binding | Q28349462 | ||
| Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice | Q28509734 | ||
| A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis | Q28593161 | ||
| Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain | Q28609769 | ||
| MLL targets SET domain methyltransferase activity to Hox gene promoters | Q28609771 | ||
| Genomic maps and comparative analysis of histone modifications in human and mouse | Q29614418 | ||
| WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development | Q29614526 | ||
| ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation | Q29618299 | ||
| Altered Hox expression and segmental identity in Mll-mutant mice | Q29620391 | ||
| The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex | Q32068521 | ||
| Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b | Q33889059 | ||
| Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins | Q34405465 | ||
| MLL: a histone methyltransferase disrupted in leukemia | Q34551607 | ||
| The many faces of histone lysine methylation | Q34688382 | ||
| Transcriptional elongation by RNA polymerase II and histone methylation | Q35134912 | ||
| 11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene | Q35865236 | ||
| The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation | Q38292124 | ||
| MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia | Q38294261 | ||
| Analysis of the murine Hoxa-9 cDNA: an alternatively spliced transcript encodes a truncated protein lacking the homeodomain | Q42674923 | ||
| Dimerization of MLL fusion proteins immortalizes hematopoietic cells | Q44615522 | ||
| Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. | Q44658575 | ||
| Definitive hematopoiesis requires the mixed-lineage leukemia gene | Q44805187 | ||
| Genomic structure and sequence analysis of human HOXA-9. | Q47969016 | ||
| Defects in yolk sac hematopoiesis in Mll-null embryos. | Q52192823 | ||
| Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex. | Q52642863 | ||
| Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling | Q61910882 | ||
| P433 | issue | 41 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 14765-14770 | |
| P577 | publication date | 2005-09-30 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | MLL associates specifically with a subset of transcriptionally active target genes | |
| P478 | volume | 102 |
| Q28298834 | A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis |
| Q38989732 | A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia. |
| Q26823816 | A double take on bivalent promoters |
| Q34536856 | A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex |
| Q42060904 | A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. |
| Q27342739 | A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line |
| Q36481741 | A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity |
| Q34531263 | ATX1-generated H3K4me3 is required for efficient elongation of transcription, not initiation, at ATX1-regulated genes |
| Q37023597 | Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia |
| Q24624389 | Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia |
| Q36082540 | Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. |
| Q37201178 | An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS |
| Q46925893 | Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development |
| Q35719929 | Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells |
| Q37459333 | Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation |
| Q34967116 | Beta-catenin hits chromatin: regulation of Wnt target gene activation |
| Q35075128 | Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. |
| Q34307027 | Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia |
| Q90015965 | Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation |
| Q91212027 | CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex |
| Q33590983 | CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin |
| Q35122366 | Challenges and opportunities in targeting the menin-MLL interaction |
| Q36436582 | Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells |
| Q28280995 | Characterization of the DOT1L network: implications of diverse roles for DOT1L |
| Q35710023 | Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression |
| Q34078612 | Chromatin control of gene expression: mixed-lineage leukemia methyltransferase SETs the stage for transcription |
| Q38286121 | Chromatin modification by the RNA Polymerase II elongation complex |
| Q51035830 | Chromatin regulators: weaving epigenetic nets. |
| Q56965961 | Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele |
| Q50287029 | Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) |
| Q51984669 | Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. |
| Q24336563 | Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells |
| Q37295285 | Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia |
| Q33278294 | Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation |
| Q33375061 | Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II |
| Q28593817 | Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation |
| Q35750333 | ECSASB2 mediates MLL degradation during hematopoietic differentiation |
| Q38866662 | Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins |
| Q37742439 | Epigenetic regulation of development by histone lysine methylation. |
| Q37619445 | Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma |
| Q27318516 | Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles |
| Q37410397 | Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. |
| Q36378382 | Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways |
| Q60919338 | Histone H3 lysine K4 methylation and its role in learning and memory |
| Q34546055 | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex |
| Q24300652 | Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance |
| Q41909550 | Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. |
| Q38994711 | Identification of mixed lineage leukemia 1(MLL1) protein as a coactivator of heat shock factor 1(HSF1) protein in response to heat shock protein 90 (HSP90) inhibition |
| Q49106909 | Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide. |
| Q48214371 | Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia |
| Q36804871 | Inferring causal relationships among different histone modifications and gene expression |
| Q42182620 | Interaction of SET domains with histones and nucleic acid structures in active chromatin. |
| Q41989052 | Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes |
| Q50605131 | Is H3K4me3 instructive for transcription activation? |
| Q64925832 | Isolation of MLL1 Inhibitory RNA Aptamers. |
| Q24655701 | Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation |
| Q37302288 | MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription |
| Q35083272 | MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome |
| Q30440771 | MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. |
| Q29615368 | MLL translocations, histone modifications and leukaemia stem-cell development |
| Q37633585 | MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches. |
| Q37895709 | MLL-SEPTIN gene fusions in hematological malignancies |
| Q37397989 | MLL1 promotes cervical carcinoma cell tumorigenesis and metastasis through interaction with β-catenin |
| Q51539776 | MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB. |
| Q37857936 | MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. |
| Q24680558 | Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes |
| Q40130350 | Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia |
| Q30425903 | Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia |
| Q43147808 | Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. |
| Q33943731 | Mixed lineage leukemia: a structure-function perspective of the MLL1 protein |
| Q33862548 | Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human |
| Q37710711 | Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. |
| Q37710708 | Mixed lineage leukemia: roles in human malignancies and potential therapy |
| Q50453702 | Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia. |
| Q35025549 | Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations |
| Q38161393 | Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis |
| Q34546063 | Molecular recognition of histone H3 by the WD40 protein WDR5. |
| Q37260555 | Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents |
| Q37630910 | Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors |
| Q33987248 | Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis |
| Q39152206 | NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. |
| Q92287236 | Non-coding RNAs in cancers with chromosomal rearrangements: the signatures, causes, functions and implications |
| Q24339403 | On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex |
| Q24305512 | PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex |
| Q33309162 | Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. |
| Q90644667 | Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans |
| Q34702215 | Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters |
| Q89226882 | Primary hyperparathyroidism |
| Q24319024 | Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression |
| Q41077260 | Profile of histone lysine methylation across transcribed mammalian chromatin |
| Q37210940 | Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved |
| Q61448728 | RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation |
| Q29614518 | Regulation of MLL1 H3K4 methyltransferase activity by its core components |
| Q42972194 | Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. |
| Q42787982 | Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover |
| Q37857841 | Risks and benefits of dietary isoflavones for cancer |
| Q37961732 | Role of H3K4 demethylases in complex neurodevelopmental diseases |
| Q37726345 | Roles of histone H3-lysine 4 methyltransferase complexes in NR-mediated gene transcription. |
| Q42291804 | Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription |
| Q38443809 | Stepping inside the realm of epigenetic modifiers. |
| Q37031819 | TET1 plays an essential oncogenic role in MLL-rearranged leukemia |
| Q35967446 | Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond |
| Q40309718 | The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes |
| Q92538045 | The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions |
| Q24319075 | The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis |
| Q37001995 | The PHD fingers of MLL block MLL fusion protein-mediated transformation |
| Q34303212 | The RNA polymerase II CTD coordinates transcription and RNA processing. |
| Q39203046 | The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter |
| Q37522825 | The molecular biology of mixed lineage leukemia |
| Q37603631 | The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation |
| Q42091115 | The role of menin in hematopoiesis |
| Q24671716 | Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference |
| Q40026914 | Transcription of laminin gamma1 chain gene in rat mesangial cells: constitutive and inducible RNA polymerase II recruitment and chromatin states |
| Q40252270 | Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. |
| Q54617530 | Two distinct roles of ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1) at promoters and within transcribed regions of ATX1-regulated genes. |
| Q46481974 | UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. |
| Q50287028 | WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) |
| Q24300306 | Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes |
| Q92099533 | Why are so many MLL lysine methyltransferases required for normal mammalian development? |
| Q40112788 | Widespread, exceptionally high levels of histone H3 lysine 4 trimethylation largely mediate "privileged" gene expression |
| Q27640447 | Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs |
| Q36936680 | ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection |
| Q42174623 | c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. |
| Q36445463 | miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia |
| Q37010564 | miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. |
| Q34124906 | p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation |
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