| scholarly article | Q13442814 |
| P50 | author | Stanley J. Korsmeyer | Q138795 |
| P2093 | author name string | Daniel Foy | |
| Patricia Ernst | |||
| William Avery | |||
| Jill K Fisher | |||
| Stacey Wade | |||
| P2860 | cites work | Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis | Q24567977 |
| Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells | Q28137796 | ||
| AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis | Q28273478 | ||
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| An early haematopoietic defect in mice lacking the transcription factor GATA-2 | Q28593072 | ||
| ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation | Q29618299 | ||
| Altered Hox expression and segmental identity in Mll-mutant mice | Q29620391 | ||
| The genetic program of hematopoietic stem cells | Q30874287 | ||
| The purification and characterization of fetal liver hematopoietic stem cells. | Q33833350 | ||
| Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo | Q34131812 | ||
| Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells | Q34197877 | ||
| Yolk-sac hematopoiesis: the first blood cells of mouse and man. | Q34331432 | ||
| The hare and the tortoise: an embryonic haematopoietic race. | Q34770415 | ||
| The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. | Q36011931 | ||
| RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development | Q36303172 | ||
| Functional characterization of B lymphocytes generated in vitro from embryonic stem cells. | Q36434592 | ||
| Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development | Q36745250 | ||
| MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis | Q37478854 | ||
| MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia | Q38294261 | ||
| Development of hematopoietic stem cell activity in the mouse embryo | Q38306839 | ||
| Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor | Q40864770 | ||
| Factors involved in leukaemogenesis and haemopoiesis | Q41676689 | ||
| Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets | Q43684705 | ||
| Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo. | Q52198673 | ||
| Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. | Q52199786 | ||
| The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages | Q71214319 | ||
| Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo | Q73168713 | ||
| Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny | Q77583284 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | leukemia | Q29496 |
| hemopoiesis | Q919283 | ||
| P1104 | number of pages | 7 | |
| P304 | page(s) | 437-443 | |
| P577 | publication date | 2004-03-01 | |
| P1433 | published in | Developmental Cell | Q1524277 |
| P1476 | title | Definitive hematopoiesis requires the mixed-lineage leukemia gene | |
| P478 | volume | 6 |
| Q50422144 | A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response |
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| Q37949892 | Acute lymphoblastic leukemia and developmental biology: a crucial interrelationship |
| Q35237394 | An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance |
| Q91212027 | CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex |
| Q99594988 | COMPASS and SWI/SNF complexes in development and disease |
| Q37124971 | Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations |
| Q36436582 | Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells |
| Q38679992 | Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research |
| Q34903800 | Chromatin regulatory mechanisms in pluripotency |
| Q27024162 | Chromatin signatures of cancer |
| Q45209344 | Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia |
| Q37109227 | Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. |
| Q34195379 | Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis |
| Q36970197 | Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators. |
| Q30422159 | Disordered epigenetic regulation in MLL-related leukemia |
| Q38855791 | Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis |
| Q37186452 | Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells |
| Q39788356 | Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease |
| Q21134949 | Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression |
| Q34244938 | Embryonic stem cell-derived hematopoietic stem cells |
| Q92730898 | Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis |
| Q89542483 | Epigenetic regulation in development: is the mouse a good model for the human? |
| Q37742439 | Epigenetic regulation of development by histone lysine methylation. |
| Q28085420 | Epigenetic regulation of endothelial-cell-mediated vascular repair |
| Q37463163 | Etoposide-initiated MLL rearrangements detected at high frequency in human primitive hematopoietic stem cells with in vitro and in vivo long-term repopulating potential |
| Q42972247 | Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression |
| Q37127231 | Getting to the stem of chronic myeloid leukaemia |
| Q24529562 | Global and Hox-specific roles for the MLL1 methyltransferase |
| Q47851108 | Got MLL? Definitive hematopoiesis requires MLL gene expression |
| Q92525522 | Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l |
| Q50478294 | Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice |
| Q35216079 | Histone modifiers in cancer: friends or foes? |
| Q37570835 | Hox, Cdx, and anteroposterior patterning in the mouse embryo |
| Q36446700 | HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development. |
| Q93344389 | IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation |
| Q35056301 | Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia |
| Q37278652 | In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9. |
| Q30479488 | Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. |
| Q37164036 | Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal |
| Q35626323 | Jarid1b targets genes regulating development and is involved in neural differentiation |
| Q57796319 | KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes |
| Q28585869 | Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia |
| Q34078397 | MLL associates specifically with a subset of transcriptionally active target genes |
| Q29615368 | MLL translocations, histone modifications and leukaemia stem-cell development |
| Q58793924 | MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity |
| Q91998149 | MLL1 promotes myogenesis by epigenetically regulating Myf5 |
| Q48262465 | MLL2 conveys transcription-independent H3K4 trimethylation in oocytes. |
| Q48022971 | MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia |
| Q34392966 | Maintenance of gene expression patterns |
| Q26861785 | Mechanisms of epigenetic regulation of leukemia onset and progression |
| Q40130350 | Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia |
| Q37109336 | Menin regulates the function of hematopoietic stem cells and lymphoid progenitors |
| Q43147808 | Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. |
| Q38100107 | Mixed lineage leukemia protein in normal and leukemic stem cells |
| Q38843624 | Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development |
| Q52369540 | Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin. |
| Q36657993 | Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes |
| Q38161393 | Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis |
| Q36232545 | Molecular pathogenesis of MLL-associated leukemias |
| Q48218289 | Molecular processes involved in B cell acute lymphoblastic leukaemia. |
| Q35183855 | Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program |
| Q28512874 | Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory |
| Q24336625 | New insight into the molecular mechanisms of MLL-associated leukemia |
| Q57810481 | Polycomb complexes in normal and malignant hematopoiesis |
| Q35029415 | Prdm16 is a physiologic regulator of hematopoietic stem cells. |
| Q53090417 | Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study. |
| Q35041289 | Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways |
| Q26863577 | Recent progress toward epigenetic therapies: the example of mixed lineage leukemia |
| Q24646499 | Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization |
| Q92482347 | Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions |
| Q28591813 | Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains |
| Q91565531 | Roles and regulation of histone methylation in animal development |
| Q36138014 | Roles of a trithorax group gene, MLL, in hematopoiesis |
| Q38994704 | SET/MLL family proteins in hematopoiesis and leukemia. |
| Q36126134 | Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor |
| Q33997220 | Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. |
| Q38698037 | Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase. |
| Q28117414 | Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation |
| Q35410612 | Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement |
| Q24304207 | Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase |
| Q28513079 | Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells |
| Q37688689 | Stem cells, DNA damage, ageing and cancer |
| Q38162595 | Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines |
| Q41352951 | TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription |
| Q41616680 | Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. |
| Q35967446 | Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond |
| Q48533330 | Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy. |
| Q26799883 | The Effect of Hypoxia on Mesenchymal Stem Cell Biology |
| Q55437673 | The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. |
| Q36590734 | The MLL partial tandem duplication in acute myeloid leukaemia |
| Q92177020 | The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation |
| Q32884582 | The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. |
| Q46927100 | The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis |
| Q51994235 | The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells. |
| Q21092410 | The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3 |
| Q39966776 | The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation |
| Q34879513 | The role of PTIP in maintaining embryonic stem cell pluripotency |
| Q42091115 | The role of menin in hematopoiesis |
| Q24536084 | The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression |
| Q41978813 | Transcription factor expression dynamics of early T-lymphocyte specification and commitment |
| Q36426330 | Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development |
| Q37863271 | Transcriptional and epigenetic networks in haematological malignancy |
| Q34765363 | USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription |
| Q39997748 | Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors |
| Q92099533 | Why are so many MLL lysine methyltransferases required for normal mammalian development? |
| Q36936680 | ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection |
| Q37504409 | p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia |
| Q41498699 | t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL |
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