Cre-mediated gene deletion in the mammary gland

scientific article

Cre-mediated gene deletion in the mammary gland is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/25.21.4323
P932PMC publication ID147032
P698PubMed publication ID9336464
P5875ResearchGate publication ID13891951

P2093author name stringLi M
Wall RJ
Gruss P
St-Onge L
Furth PA
Hennighausen L
Garrett L
Wynshaw-Boris A
Wagner KU
P2860cites workTissue- and site-specific DNA recombination in transgenic miceQ21999077
Targeted oncogene activation by site-specific recombination in transgenic miceQ24564632
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2Q28236543
Bacteriophage P1 site-specific recombination. I. Recombination between loxP sitesQ28264411
Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiaeQ28288561
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cellsQ29614542
Inducible gene targeting in miceQ29614544
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouseQ29618622
A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic miceQ33638859
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivoQ34163139
Comparison of the whey acidic protein genra of the rat and mouseQ34245576
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneQ34560337
Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic miceQ34601019
Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoterQ34612904
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.Q35778832
The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic miceQ35793329
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinaseQ40396045
Lactogenic Hormone and Cell Type-Specific Control of the Whey Acidic Protein Gene Promoter in Transfected Mouse CellsQ41659023
Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive systemQ42521403
Whey acidic protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary developmentQ45789697
Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ lineQ46188484
Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.Q52237167
Comparison of the regulation of the whey acidic protein gene with that of a hybrid gene containing the whey acidic protein gene promoter in transgenic mice.Q52249832
Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigenQ71246762
Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiationQ71957674
P433issue21
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)4323-4330
P577publication date1997-11-01
P1433published inNucleic Acids ResearchQ135122
P1476titleCre-mediated gene deletion in the mammary gland
P478volume25

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cites work (P2860)
Q36200972A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors
Q41664251A Unifying Theory of Branching Morphogenesis
Q36982090A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.
Q90029662A mouse model engineered to conditionally express the progesterone receptor-B isoform
Q34589086A segmental deletion series generated by sister-chromatid transposition of Ac transposable elements in maize
Q33939630A single vector containing modified cre recombinase and LOX recombination sequences for inducible tissue-specific amplification of gene expression
Q37631216A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis
Q36769677ATG proteins mediate efferocytosis and suppress inflammation in mammary involution
Q40076402ATM is required for SOD2 expression and homeostasis within the mammary gland.
Q42457867Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Q33897191Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.
Q28584971Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
Q28087050Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration
Q52322881Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression.
Q90504024Alveolar progenitor cells in the mammary gland are dependent on the β4 integrin
Q33615688Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics
Q35112126Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.
Q64062826An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle
Q36884758An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland
Q40374590An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance
Q52605706Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit.
Q36669208Analysis of lactation defects in transgenic mice
Q51356918Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors.
Q35157919Assessing estrogen signaling aberrations in breast cancer risk using genetically engineered mouse models
Q37086261Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.
Q91117890B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model
Q36406519BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer
Q33699417Bcl-2 gene family and related proteins in mammary gland involution and breast cancer
Q36688779Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin
Q42377924Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo
Q34425850CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland
Q57456357Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast
Q33947281Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells
Q39223363Characterization of WWOX inactivation in murine mammary gland development
Q47199203Characterization of mammary-specific disruptions for Tph1 and Lrp5 during murine lactation
Q34218211Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
Q37069878Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer
Q35241200Comparison of radioimmuno and carbon nanotube field-effect transistor assays for measuring insulin-like growth factor-1 in a preclinical model of human breast cancer
Q36549790Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
Q43814258Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.
Q35986081Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.
Q37103753Conditional gene expression systems to study herpesvirus biology in vivo.
Q30496549Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation
Q34503454Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
Q33761949Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function
Q35151873Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice
Q39301635Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis.
Q34485060Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution
Q37732569Coregulation of genetic programs by the transcription factors NFIB and STAT5.
Q47867267Cre recombinase-mediated gene targeting of mesenchymal cells
Q45103581Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models
Q36240642Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.
Q35110797Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.
Q28589097Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis
Q46218974Deletion of a coordinate regulator of type 2 cytokine expression in mice
Q36356105Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis
Q33853864Development of a unique system for spatiotemporal and lineage-specific gene expression in mice
Q48348820Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice
Q28585680Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
Q33788940Differential requirement of GRP94 and GRP78 in mammary gland development.
Q28587922Disruption of the mouse necdin gene results in early post-natal lethality
Q57020648Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing
Q38275614E-cadherin's role in development, tissue homeostasis and disease: Insights from mouse models: Tissue-specific inactivation of the adhesion protein E-cadherin in mice reveals its functions in health and disease
Q38904675EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Q34288822EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Q36328085ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex
Q52181362Efficient BLG-Cre mediated gene deletion in the mammary gland.
Q38678926Efficient gene activation in cultured mammalian cells mediated by FLP recombinase-expressing recombinant adenovirus
Q92643076Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus
Q34516742Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge
Q38356103Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5.
Q47745236Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Q33556265Epidermal Smad4 deletion results in aberrant wound healing
Q36833386Epigenetic instability at imprinting control regions in a Kras(G12D)-induced T-cell neoplasm.
Q41524206Epigenetic response of imprinted domains during carcinogenesis
Q99603541Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development
Q35479646ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis
Q89697297Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line
Q37674501Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway
Q35777328Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice
Q35990241Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice
Q27309251Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer
Q26995224Expanding the scope of site-specific recombinases for genetic and metabolic engineering
Q24806283Experimental manipulation of radiographic density in mouse mammary gland
Q50316899Expression of the mRNA stability regulator Tristetraprolin is required for lactation maintenance in the mouse mammary gland
Q28584871Fatty acid synthase is required for mammary gland development and milk production during lactation
Q60321839Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression
Q33768293Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer
Q36106731FoxM1 regulates mammary luminal cell fate
Q33641744Foxa1 is essential for mammary duct formation.
Q91871605Fry Is Required for Mammary Gland Development During Pregnant Periods and Affects the Morphology and Growth of Breast Cancer Cells
Q34361027Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling
Q77158823Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene
Q35885872Functions of myc:max in the control of cell proliferation and tumorigenesis
Q34573593Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
Q52572633Gene targeting methods for studying nuclear transport factors in mice.
Q50483313Generation of Janus kinase 1 (JAK1) conditional knockout mice.
Q28585073Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
Q34286291Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice
Q46605059Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.
Q33406237Genetic mechanisms in Apc-mediated mammary tumorigenesis
Q36670266Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development.
Q33578641Genetically engineered ERα-positive breast cancer mouse models
Q31112063Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis
Q36957145HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.
Q42484138Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
Q36843802Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
Q45246446High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands.
Q27312162Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC
Q53530644IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
Q34348008Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice
Q35171080In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
Q48216942In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling
Q37104726Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models
Q37493064Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
Q59137669Inhibition of AKT suppresses the initiation and progression of -associated mammary tumors
Q58786210Inhibition of Estrogen Signaling Reduces the Incidence of -associated Mammary Tumor Formation
Q102379359Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo
Q35676688Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo
Q42678959Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue
Q37122579Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.
Q93274029Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
Q28588240Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
Q24802378Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?
Q36512944Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer
Q37416013Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.
Q60950454Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland
Q35558962Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice
Q36422318Loss of BRCA1 leads to an increased sensitivity to Bisphenol A.
Q48006079Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.
Q36160621Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.
Q64057070Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice
Q34522002Loss of PPARγ expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment
Q99605770Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer
Q34300607Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.
Q47970005Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development
Q45988712Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.
Q52051392Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.
Q33587338Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice
Q43909419Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility
Q36702175Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
Q28250940MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer
Q34647947MMTV-Cre transgenes can adversely affect lactation: considerations for conditional gene deletion in mammary tissue
Q90673081MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma
Q36084382Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis.
Q38964566Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice
Q37576068Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo
Q33837757Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function
Q33682960Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
Q24645591Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation
Q34990925Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice
Q36600478Manganese superoxide dismutase is dispensable for post-natal development and lactation in the murine mammary gland
Q34144845Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice
Q37568407MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse
Q40599114MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene
Q27321385Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation
Q91891592Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
Q37051766Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland
Q34667643Modelling breast cancer: one size does not fit all.
Q24803741Models of breast cancer: quo vadis, animal modeling?
Q33923742Modification and repression of genes expressed in the mammary gland using gene targeting and other technologies
Q50093958Mouse Models of Erythropoiesis and Associated Diseases.
Q42137028Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo
Q24797754Mouse models for breast cancer
Q36602578Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects
Q38055069Mouse models of BRCA1 and their application to breast cancer research
Q38079299Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.
Q42472188Mouse models of breast cancer
Q34553964Mouse models of breast cancer metastasis
Q36451974N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland
Q33699422NF-kappaB and apoptosis in mammary epithelial cells
Q29614484NIX is required for programmed mitochondrial clearance during reticulocyte maturation
Q35057667Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland
Q37690101New insights into lineage restriction of mammary gland epithelium using parity-identified mammary epithelial cells.
Q90598191Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
Q97686592Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes
Q36382641Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor
Q30417842Overexpression of follistatin in the mouse epididymis disrupts fluid resorption and sperm transit in testicular excurrent ducts
Q33616502Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation
Q92534377PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Q38718336PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.
Q28508026Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells
Q50701525Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells.
Q44069585Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice
Q81097777Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression
Q35929384Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells
Q37364696Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis
Q34801773Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.
Q28729079Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors
Q48926254Prediction of transgene integration by noninvasive bioluminescent screening of microinjected bovine embryos
Q36123672Pregnancy and stem cell behavior
Q35192742Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
Q44409381Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions
Q28602310Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas
Q39670403RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
Q42935431RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice
Q35240492RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.
Q30496322Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status
Q37478749Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis
Q30419961Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice
Q35683608Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
Q35417300Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice
Q36949096Reprogramming stem cells is a microenvironmental task
Q51102156Responsiveness of Brca1 and Trp53 Deficiency-Induced Mammary Preneoplasia to Selective Estrogen Modulators versus an Aromatase Inhibitor in Mus musculus.
Q47411248Reversed end Ds element: a novel tool for chromosome engineering in Arabidopsis
Q37695777Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
Q39892896Role of a heterologous retroviral transport element in the development of genetic complementation assay for mouse mammary tumor virus (MMTV) replication
Q34363614Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice
Q33860834Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation
Q34258504Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer
Q27315980Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland
Q90661038Scribble promotes alveologenesis in the pregnant mammary gland for milk production
Q24547568Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Q34820264Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium
Q33657413Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis
Q36580933Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration
Q35761138Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Q34434909Signaling pathways in mammary gland development.
Q54462818Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
Q51997629Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis.
Q48870288Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.
Q42521880Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia
Q35056355Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.
Q37713579Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.
Q27023444Strategies to achieve conditional gene mutation in mice
Q52544495Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
Q35764397T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
Q92740008TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh
Q33955287TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis
Q34571586TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution
Q36476219Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Q37379679Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy
Q40717361Targeting mammary epithelial cells using a bacterial artificial chromosome
Q47962163Techniques for the Reprogramming of Exogenous Stem/Progenitor Cell Populations Towards a Mammary Epithelial Cell Fate.
Q37194214Telomerase and estrogen-sensing activities are essential for continued mammary growth in vivo but dispensable for "reprogramming" neural stem cells
Q73143435Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice
Q33835605Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.
Q33650414Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis
Q34170839The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner
Q36953001The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells
Q38302448The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells
Q36888347The PPARγ agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency
Q91816605The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex
Q37122729The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine
Q77759873The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility
Q33652431The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells
Q54122849The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution.
Q54977412The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation.
Q42492889The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy
Q24630889The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development
Q84395807The high-level expression of human tissue plasminogen activator in the milk of transgenic mice with hybrid gene locus strategy
Q36937069The mammary microenvironment alters the differentiation repertoire of neural stem cells
Q36577825The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development.
Q35861709The mouse mammary microenvironment redirects mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate.
Q36388077The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells
Q27851848The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis
Q37587063The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis
Q35657873The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium
Q73143411The right time and place for molecular scissors
Q34978975The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells
Q35067253The role of prolactin in mammary carcinoma
Q90695287The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Q57184205The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Q100750439The transcription factor Sox10 is an essential determinant of branching morphogenesis and involution in the mouse mammary gland
Q37617637The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models
Q64114526Therapeutic targeting of and mutant breast cancer through mutant p53 reactivation
Q40519923Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.
Q64958992Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.
Q34114603Transgenic animal bioreactors
Q34462948Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues
Q34580724Tumor formation in Brca1 conditional mutant mice
Q35787307Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
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