Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity

scientific article

Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.01188-10
P953full work available at URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067508
P932PMC publication ID3067508
P698PubMed publication ID21173306

P2093author name stringJing Wu
Eric H Weening
Magnus Höök
Jon T Skare
Jennifer B Faske
P2860cites workThe emergence of Lyme diseaseQ22241895
Diagnosis of lyme borreliosisQ22242237
Lyme DiseaseQ22250902
Involvement of Src tyrosine kinase in Escherichia coli invasion of human brain microvascular endothelial cellsQ24316010
Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cellsQ24548752
SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingQ24551043
Intracellular localization of Borrelia burgdorferi within human endothelial cellsQ24644557
Eucaryotic cells protect Borrelia burgdorferi from the action of penicillin and ceftriaxone but not from the action of doxycycline and erythromycinQ24675848
Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living hostQ27318574
Pathogenic bacteria attach to human fibronectin through a tandem beta-zipperQ27641182
Integrins: bidirectional, allosteric signaling machinesQ27860700
Serum-starvation-induced changes in protein synthesis and morphology of Borrelia burgdorferiQ28144039
Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migransQ28207826
Invasion and cytopathic killing of human lymphocytes by spirochetes causing Lyme diseaseQ28244477
Invasion of human neuronal and glial cells by an infectious strain of Borrelia burgdorferiQ28268739
Invasion of human skin fibroblasts by the Lyme disease spirochete, Borrelia burgdorferiQ28268925
BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand bindingQ28902813
Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanismQ30490061
Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-betaQ33450590
Characterization of a conditional bosR mutant in Borrelia burgdorferiQ33557862
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirocheteQ33585831
Bacillus anthracis spore entry into epithelial cells is an actin-dependent process requiring c-Src and PI3K.Q33638446
Intracellular invasion by Orientia tsutsugamushi is mediated by integrin signaling and actin cytoskeleton rearrangementsQ33826088
Cell adhesion molecules in the pathogenesis of and host defence against microbial infectionQ33850097
Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1.Q34005702
Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.Q34087039
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferiQ34352235
Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoformsQ34440606
Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferationQ34581935
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian hostQ50104321
Conformational changes in the fibronectin binding MSCRAMMs are induced by ligand binding.Q50752867
Regulated expression of fibronectin, laminin and related integrin receptors during the early chondrocyte differentiation.Q52192439
Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases.Q53921972
Human Phagocytic Cells in the Early Innate Immune Response toBorrelia burgdorferiQ58424640
Staphylococcus aureusSmall‐Colony Variants Are Adapted Phenotypes for Intracellular PersistenceQ58574042
Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cellsQ62662380
Inactivation of the fibronectin-binding adhesin genebbk32significantly attenuates the infectivity potential ofBorrelia burgdorferiQ62966001
The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregationQ70660152
Human dendritic cells phagocytose and process Borrelia burgdorferiQ71555606
Sera from patients with chronic Lyme disease protect mice from Lyme borreliosisQ72363727
An enhanced GFP reporter system to monitor gene expression in Borrelia burgdorferiQ73653576
Lyme borreliosisQ77143423
New Antibiotic Resistance Cassettes Suitable for Genetic Studies in <i>Borrelia burgdorferi</i>Q79237809
Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1Q79755060
Invasion mechanisms of Gram-positive pathogenic cocciQ81235523
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicityQ34681119
Antibody-mediated disease remission in the mouse model of lyme borreliosisQ34975726
Bacterial pathogenesis: exploiting cellular adherenceQ35547387
Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levelsQ35634802
Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon productionQ35783879
Chronic Lyme borreliosis in the laboratory mouse.Q35833566
Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirocheteQ36230800
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureusQ36365979
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme diseaseQ36366179
Risk of culture-confirmed borrelial persistence in patients treated for erythema migrans and possible mechanisms of resistanceQ36418327
Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytesQ36422052
Cellular adhesion molecules as targets for bacterial infectionQ36425003
Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cationsQ36529067
Persistence of Borrelia burgdorferi following antibiotic treatment in miceQ36593814
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infectionQ36974447
Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytesQ36982748
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosisQ37036076
Antimicrobial mechanisms of phagocytes and bacterial evasion strategiesQ37445493
Bacterial manipulation of innate immunity to promote infection.Q37675898
An arthritogenic alphavirus uses the alpha1beta1 integrin collagen receptorQ39155029
Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinasesQ39736489
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cellsQ39824982
Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes.Q39825549
Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycansQ40337641
Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureusQ40643410
De novo formation of focal complex-like structures in host cells by invading Streptococci.Q40782833
Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1.Q40826567
Cellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrinsQ40840769
Roles of integrins and fibronectin in the entry of Streptococcus pyogenes into cells via protein F1.Q40993658
Down-regulation of integrin alpha 1/beta 1 expression and association with cell rounding in human cytomegalovirus-infected fibroblastsQ41414167
Phagocytic cell responses to in vivo and in vitro exposure to the Lyme disease spirochete.Q41531578
Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1.Q41839874
Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosaQ41887163
Cultured endothelial cells from human arteriovenous malformations have defective growth regulation.Q42477218
Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetesQ42649010
Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocystsQ42771254
A novel fibronectin binding motif in MSCRAMMs targets F3 modulesQ43142871
Upregulation of alpha(8)beta(1)-integrin in cardiac fibroblast by angiotensin II and transforming growth factor-beta1.Q43766302
Alpha8beta1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardiumQ44792716
A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferiQ45156915
Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injuryQ45234592
Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisationQ46458595
High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules.Q47215441
Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31.Q47988454
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectBorrelia burgdorferiQ2723634
P1104number of pages11
P304page(s)1338-1348
P577publication date2010-12-20
P1433published inInfection and ImmunityQ6029193
P1476titleInvasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity
P478volume79

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cites work (P2860)
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Q30528723Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

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