A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection (scientific article)

Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses

Q36424574

Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India

Q37179996

Phenotype variation in human immunodeficiency virus type 1 transmission and disease progression

Q37628364

Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection

Q37704735

Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop

Q38610031

Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes

Q38979142

Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome

Q39031676

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

Q39351549

Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enh

Q39351562

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

Q39464591

Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.

Q39521282

Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children

Q39539214

Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding

Q39539552

V2 loop glycosylation of the human immunodeficiency virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodies

Q39592261

Mutation at a single position in the V2 domain of the HIV-1 envelope protein confers neutralization sensitivity to a highly neutralization-resistant virus

Q41844960

Different rates of disease progression of HIV type 1 infection in Tanzania based on infecting subtype

Q43947197

HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor

Q48111569

Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

Q55487007

HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads

Q79935060

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

Q24561905

Molecular architecture of native HIV-1 gp120 trimers

Q27651385

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Q27658449

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Q27759364

Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda

Q28217042

The antigenic structure of the HIV gp120 envelope glycoprotein

Q28274698

Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

Q29547347

Structure of an unliganded simian immunodeficiency virus gp120 core

Q29616089

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

Q29619254

Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41.

Q33313394

Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy

Q33683115

Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences.

Q33724118

Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages

Q33787402

Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease--indication of an evolving epidemic in West Africa

Q33793066

Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domains

Q33796067

Association of structural changes in the V2 and V3 loops of the gp120 envelope glycoprotein with acquisition of neutralization resistance in a simian-human immunodeficiency virus passaged in vivo

Q33813212

Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates

Q33824289

The level of CD4 expression limits infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses

Q33826504

Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity

Q33847458

Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate

Q33851094

HIV-1 viral subtype differences in the rate of CD4+ T-cell decline among HIV seroincident antiretroviral naive persons in Rakai district, Uganda

Q33882090

Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?

Q33887693

The role of the third beta strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012

Q33953062

HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda

Q34135328

Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis

Q34170655

The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection

Q34317025

Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.

Q34340428

Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.

Q34717126

Cell surface receptors, virus entry and tropism of primate lentiviruses

Q34747252

The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.

Q35062297

Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design

Q35196671

Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

Q36340560

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

macrophage

Q184204

P304

page(s)

2397-2405

P577

publication date

2010-12-15

P1433

published in

Journal of Virology

Q1251128

P1476

title

A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection

P478

volume

Reverse relations

cites work (P2860)

Q34482480	A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia
Q38703060	Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor
Q28485983	Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity
Q35274763	Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages
Q35956940	Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity
Q39240591	Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5.
Q60046351	CCR5 structural plasticity shapes HIV-1 phenotypic properties
Q36298503	Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.
Q36878906	Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus
Q34503200	Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies
Q39314021	Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism
Q37646885	Flow virometric sorting and analysis of HIV quasispecies from plasma
Q47423769	HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded
Q26825087	HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies
Q35216488	HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages
Q34050421	HIV-1 replication in the central nervous system occurs in two distinct cell types.
Q35196509	HIV-1 target cells in the CNS.
Q64936398	High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer.
Q37102101	Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.
Q39615794	Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.
Q38645990	Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications
Q35996364	Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.
Q35694015	Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.
Q35076953	Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors
Q38860309	Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission
Q36476641	Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5
Q49824521	Molecular Signatures of HIV-1 Envelope Associated with HIV-Associated Neurocognitive Disorders.
Q36281817	Phenotypic Correlates of HIV-1 Macrophage Tropism
Q24635002	Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals
Q35817106	Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies.
Q37366342	Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins
Q35842116	Role for the terminal clasp of HIV-1 gp41 glycoprotein in the initiation of membrane fusion
Q36184440	Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations
Q34499013	Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity
Q34292319	Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
Q36856091	The HIV-1 env protein: a coat of many colors
Q37646891	Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques
Q36607127	Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
Q41682866	UCLA1 aptamer inhibition of human immunodeficiency virus type 1 subtype C primary isolates in macrophages and selection of resistance
Q27678226	Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
Q35593158	Viral determinants of HIV-1 macrophage tropism
Q38936957	Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.