Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages

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Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.05510-11
P932PMC publication ID3187472
P698PubMed publication ID21835796

P50authorMichael RocheQ43480572
Paul A. RamslandQ38317548
Jasminka SterjovskiQ39034626
Lachlan GrayQ39034643
Anthony L. CunninghamQ39034658
P2093author name stringPaul R Gorry
Anne Ellett
Melissa J Churchill
Kieran Cashin
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Identification of a major co-receptor for primary isolates of HIV-1Q22251282
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonistsQ24619974
Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4Q27648643
Molecular architecture of native HIV-1 gp120 trimersQ27651385
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobilityQ27658989
Comparative protein modelling by satisfaction of spatial restraintsQ27860866
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesQ28282895
Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cellsQ28288205
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humansQ28345408
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entryQ28475912
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Contrasting Use of CCR5 Structural Determinants by R5 and R5X4 Variants within a Human Immunodeficiency Virus Type 1 Primary Isolate QuasispeciesQ40132975
Phenotypic characteristics of human immunodeficiency virus type 1 subtype C isolates of Ethiopian AIDS patientsQ40953782
An immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 (HXB2-Env:Ala 582(-->Thr)) decreases viral neutralization by monoclonal antibodies to the CD4-binding siteQ41530101
Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI.Q41655443
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.Q41857055
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entryQ43694761
Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal regionQ44106148
CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicityQ44601067
Envelope glycoprotein determinants of increased entry in a pathogenic simian-human immunodeficiency virus (SHIV-HXBc2P 3.2) passaged in monkeysQ45666386
HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitorQ48111569
Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene.Q54381624
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5Q29616094
Structure of a V3-containing HIV-1 gp120 coreQ29619014
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.Q29622903
Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization.Q30423779
Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism.Q33648601
Preferential use of CXCR4 by R5X4 human immunodeficiency virus type 1 isolates for infection of primary lymphocytesQ33716586
HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entryQ33807529
Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolatesQ33824289
Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimersQ33836042
Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificityQ33847458
Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolateQ33851094
HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cellsQ33990552
Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.Q34008699
Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infectionQ34065091
The plasma membrane as a combat zone in the HIV battlefieldQ34078723
Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cellsQ34142829
Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.Q34340428
Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 alleleQ34545588
Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.Q34717126
A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infectionQ34741807
An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopesQ34987062
R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategiesQ35018129
The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.Q35062297
HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropismQ35076868
Spontaneous reversion of human immunodeficiency virus type 1 neutralization-resistant variant HXB2thr582: in vitro selection against cytopathicity highlights gp120-gp41 interactive regions.Q35835261
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.Q35890885
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.Q35985849
HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypesQ36573144
An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1Q36687524
The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitopeQ36809662
Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS.Q36890344
Only five of 10 strictly conserved disulfide bonds are essential for folding and eight for function of the HIV-1 envelope glycoproteinQ36914293
Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissuesQ37015492
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.Q37146880
Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brainQ37191794
Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization.Q37275049
Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicrivirocQ37452124
Entry inhibitors in the treatment of HIV-1 infectionQ37580460
Coreceptors and HIV-1 pathogenesisQ37824291
Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell lineQ38324749
A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5Q38341741
Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopesQ38979142
Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12.Q38979760
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5Q39000358
Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophagesQ39021508
A molecular clone of HIV-1 tropic and cytopathic for human and chimpanzee lymphocytes.Q39022595
Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndromeQ39031676
The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell-depleted rhesus monkeysQ39092739
Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5.Q39317816
Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.Q39351549
Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhQ39351562
Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.Q39521282
Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.Q39523186
Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope.Q39549145
Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses.Q39549670
Envelope glycoprotein determinants of increased fusogenicity in a pathogenic simian-human immunodeficiency virus (SHIV-KB9) passaged in vivoQ39590956
Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection.Q39616140
The crown and stem of the V3 loop play distinct roles in human immunodeficiency virus type 1 envelope glycoprotein interactions with the CCR5 coreceptorQ39686562
Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: implications for HIV fusion and entry eventsQ39755287
Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia.Q40113932
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)10699-10709
P577publication date2011-08-10
P1433published inJournal of VirologyQ1251128
P1476titleAlternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages
P478volume85

Reverse relations

cites work (P2860)
Q35666270A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops
Q36827946A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
Q36028163CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells.
Q37324797Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo
Q34537513Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4(+) T-cell subsets, including stem cell memory T-cells
Q92990096Different Patterns of HIV-1 Replication in MACROPHAGES is Led by Co-Receptor Usage
Q26825087HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies
Q35196509HIV-1 target cells in the CNS.
Q37102101Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.
Q37362368Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection
Q34792976Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection.
Q36476641Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5
Q31153030Moderate restriction of macrophage-tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages
Q36281817Phenotypic Correlates of HIV-1 Macrophage Tropism
Q30372085Reliable genotypic tropism tests for the major HIV-1 subtypes
Q38973552Specific VpU codon changes were significantly associated with gp120 V3 tropic signatures in HIV-1 B-subtype.
Q62572413Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12
Q36856091The HIV-1 env protein: a coat of many colors
Q33711710The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain
Q35593158Viral determinants of HIV-1 macrophage tropism

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