| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2006PNAS..10315160D |
| P356 | DOI | 10.1073/PNAS.0605513103 |
| P932 | PMC publication ID | 1586182 |
| P698 | PubMed publication ID | 17015824 |
| P5875 | ResearchGate publication ID | 6778913 |
| P50 | author | Steven M. Wolinsky | Q45517979 |
| Dana Gabuzda | Q91131980 | ||
| P2093 | author name string | Paul R Gorry | |
| Jianbin Wang | |||
| Elaine R Thomas | |||
| Kevin Kunstman | |||
| Joann Taylor | |||
| Rebecca L Dunfee | |||
| P2860 | cites work | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody | Q27759364 |
| The neuropathogenesis of AIDS | Q28300983 | ||
| CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia | Q28303212 | ||
| Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans | Q28345408 | ||
| Structure of a V3-containing HIV-1 gp120 core | Q29619014 | ||
| Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS | Q33341366 | ||
| Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy. | Q33716348 | ||
| Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia. | Q33783434 | ||
| Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients | Q33785357 | ||
| Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages | Q33787402 | ||
| Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolate | Q33788874 | ||
| Reevaluation of amino acid variability of the human immunodeficiency virus type 1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes | Q33803939 | ||
| Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates | Q33824289 | ||
| The level of CD4 expression limits infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses | Q33826504 | ||
| Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity | Q33847458 | ||
| Identification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system. | Q33850041 | ||
| Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate | Q33851094 | ||
| Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infection | Q34065091 | ||
| Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells | Q34142829 | ||
| Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. | Q34340428 | ||
| Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence | Q35890115 | ||
| Pathogenesis of macrophage tropic HIV-1. | Q36002727 | ||
| Mechanisms of HIV-1 neurotropism | Q36536166 | ||
| Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences | Q36623074 | ||
| Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences | Q36637273 | ||
| Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques | Q36698054 | ||
| Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS. | Q36890344 | ||
| Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome | Q39031676 | ||
| Complex determinants of macrophage tropism in env of simian immunodeficiency virus | Q39268981 | ||
| Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enh | Q39351562 | ||
| HIV-1 chemokine coreceptor utilization in paired cerebrospinal fluid and plasma samples: a survey of subjects with viremia | Q39483826 | ||
| Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. | Q39548654 | ||
| Mosaic structure of the human immunodeficiency virus type 1 genome infecting lymphoid cells and the brain: evidence for frequent in vivo recombination events in the evolution of regional populations. | Q39596106 | ||
| Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: implications for HIV fusion and entry events | Q39755287 | ||
| HIV-1 heterogeneity and cytokines. Neuropathogenesis. | Q41005800 | ||
| Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain | Q42628808 | ||
| Human immunodeficiency virus type 1 RNA populations in faeces with higher homology to intestinal populations than to blood populations | Q42642202 | ||
| Beta-turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site | Q44008709 | ||
| Gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates | Q45069901 | ||
| Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines | Q45733145 | ||
| Differences in human immunodeficiency virus type 1 V3 sequences from patients with and without AIDS dementia complex | Q45784231 | ||
| HIV vaccine design and the neutralizing antibody problem | Q46474020 | ||
| Independent evolution of HIV type 1 in different brain regions | Q47953400 | ||
| V3 sequences of paired HIV-1 isolates from blood and cerebrospinal fluid cluster according to host and show variation related to the clinical stage of disease. | Q48098565 | ||
| Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): evidence for neurotropic HIV variants | Q48383182 | ||
| Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usage. | Q48650366 | ||
| Surface CD4 Is Critical to in Vitro HIV Infection of Human Alveolar Macrophages | Q58003944 | ||
| P433 | issue | 41 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | macrophage | Q184204 |
| P304 | page(s) | 15160-15165 | |
| P577 | publication date | 2006-10-02 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia | |
| P478 | volume | 103 |
| Q34741807 | A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection |
| Q34482480 | A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia |
| Q41930708 | A single gp120 residue can affect HIV-1 tropism in macaques. |
| Q30654651 | A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity. |
| Q36397434 | A species-specific amino acid difference in the macaque CD4 receptor restricts replication by global circulating HIV-1 variants representing viruses from recent infection |
| Q55328454 | Affinofile Assay for Identifying Macrophage-Tropic HIV-1. |
| Q35274763 | Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages |
| Q34987062 | An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes |
| Q34008699 | Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. |
| Q39240591 | Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5. |
| Q36530897 | Biomarkers of HIV-1-associated neurocognitive disorders: challenges of proteomic approaches |
| Q60046351 | CCR5 structural plasticity shapes HIV-1 phenotypic properties |
| Q37123579 | CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo |
| Q44601067 | CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity |
| Q92345552 | CROI 2019: neurologic complications of HIV disease |
| Q34539781 | Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children |
| Q41978842 | Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection |
| Q35606068 | Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS. |
| Q28475360 | Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementia |
| Q35219829 | Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection |
| Q35069459 | Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues |
| Q34950897 | Cross-sectional characterization of HIV-1 env compartmentalization in cerebrospinal fluid over the full disease course |
| Q36298503 | Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality. |
| Q38979142 | Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes |
| Q28551914 | Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus |
| Q37638965 | Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence |
| Q42222894 | Discordant patterns of tissue-specific genetic characteristics in the HIV-1 env gene from HIV-associated neurocognitive disorder (HAND) and non-HAND patients |
| Q39314021 | Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism |
| Q38979760 | Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12. |
| Q36847475 | Envelope gene evolution and HIV-1 neuropathogenesis |
| Q35567289 | Eradication of human immunodeficiency virus from brain reservoirs |
| Q92177858 | Evidence for both Intermittent and Persistent Compartmentalization of HIV-1 in the Female Genital Tract |
| Q35826158 | Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages |
| Q37273158 | Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection |
| Q33819189 | Genetic variation and HIV-associated neurologic disease. |
| Q37300347 | HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads. |
| Q37042148 | HIV gp120 sequence variability associated with HAND in Hispanic Women. |
| Q34135328 | HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda |
| Q37505823 | HIV-1 Latency and Eradication: Past, Present and Future |
| Q35995791 | HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity |
| Q47423769 | HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded |
| Q36124813 | HIV-1 clade B and C isolates exhibit differential replication: relevance to macrophage-mediated neurotoxicity |
| Q26825087 | HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies |
| Q35076868 | HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism |
| Q42428236 | HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12. |
| Q35216488 | HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages |
| Q34050421 | HIV-1 replication in the central nervous system occurs in two distinct cell types. |
| Q35196509 | HIV-1 target cells in the CNS. |
| Q33939729 | HIV-associated neurocognitive disorder. |
| Q37416015 | Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders |
| Q90609804 | Human Immunodeficiency Virus Type 1 RNA Detected in the Central Nervous System (CNS) After Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells |
| Q37356028 | Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection. |
| Q37051645 | Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma |
| Q35702700 | Human immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration. |
| Q38645990 | Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications |
| Q40461425 | Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. |
| Q37727880 | Immune Responses in the Central Nervous System Are Anatomically Segregated in a Non-Human Primate Model of Human Immunodeficiency Virus Infection |
| Q35996364 | Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue. |
| Q39282294 | Induction of IL-6 and CCL5 (RANTES) in human respiratory epithelial (A549) cells by clinical isolates of respiratory syncytial virus is strain specific |
| Q35694015 | Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes. |
| Q27487936 | Infectious Diseases of the Nervous System and Their Impact in Developing Countries |
| Q35076953 | Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors |
| Q36155019 | Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding |
| Q35838394 | Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment |
| Q38860309 | Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission |
| Q40113932 | Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia. |
| Q39521282 | Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion. |
| Q36476641 | Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5 |
| Q57009014 | Macrophages and the Viral Dissemination Super Highway |
| Q42744934 | Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies |
| Q49824521 | Molecular Signatures of HIV-1 Envelope Associated with HIV-Associated Neurocognitive Disorders. |
| Q38610031 | Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop |
| Q39186710 | Natural variation in the V3 crown of human immunodeficiency virus type 1 affects replicative fitness and entry inhibitor sensitivity |
| Q35815274 | Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts |
| Q39539821 | Neurological infections: clinical advances and emerging threats. |
| Q36845926 | Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain |
| Q58555286 | No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications |
| Q36281817 | Phenotypic Correlates of HIV-1 Macrophage Tropism |
| Q47548593 | Prediction of HIV-associated neurocognitive disorder (HAND) from three genetic features of envelope gp120 glycoprotein. |
| Q40070343 | Probing the compartmentalization of HIV-1 in the central nervous system through its neutralization properties. |
| Q36498596 | Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator |
| Q36184440 | Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations |
| Q64979797 | Selective use of primate CD4 receptors by HIV-1. |
| Q39422249 | Sequencing the Biology of Entry: The Retroviral env Gene |
| Q36121837 | Sera proteomic biomarker profiling in HIV-1 infected subjects with cognitive impairment |
| Q34091371 | Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope. |
| Q33426352 | Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state |
| Q62572413 | Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12 |
| Q36856091 | The HIV-1 env protein: a coat of many colors |
| Q36957295 | The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors |
| Q36906001 | The effects of cocaine on HIV transcription |
| Q37410623 | The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env. |
| Q37646891 | Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques |
| Q37191794 | Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain |
| Q35076664 | Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates |
| Q52567903 | Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues. |
| Q34441935 | Unique C2V3 sequence in HIV-1 envelope obtained from broadly neutralizing plasma of a slow progressing patient conferred enhanced virus neutralization |
| Q37200962 | Update on HIV-associated neurocognitive disorders |
| Q39351549 | Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors. |
| Q34170655 | Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis |
| Q37015492 | Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues |
| Q34203163 | Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection |
| Q35593158 | Viral determinants of HIV-1 macrophage tropism |
| Q38936957 | Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages. |
| Q36188164 | When human immunodeficiency virus meets chemokines and microglia: neuroprotection or neurodegeneration? |
| Q37590425 | Where does HIV hide? A focus on the central nervous system |
| Q37201215 | YKL-40: a candidate biomarker for simian immunodeficiency virus and human immunodeficiency virus encephalitis? |
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