Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

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Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability is …
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scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2014.10.020
P932PMC publication ID4272638
P698PubMed publication ID25435140
P5875ResearchGate publication ID268986135

P50authorAndrés AguileraQ37382275
María L García-RubioQ43158419
P2093author name stringKarlene A Cimprich
Caroline Townsend Stork
Julie Sollier
Renee D Paulsen
P2860cites workInstability and decay of the primary structure of DNAQ22122361
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivoQ24300037
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent terminationQ24307617
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repairQ24312736
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4)Q24533845
SF1 and SF2 helicases: family mattersQ24596016
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksQ24651854
A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiaeQ27929512
Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genesQ27935087
Transcription-associated R-loop formation across the human FMR1 CGG-repeat regionQ28537978
Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPFQ28592372
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesisQ30435228
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage responseQ30532840
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stabilityQ33489221
C9orf72 nucleotide repeat structures initiate molecular cascades of disease.Q33715387
A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expressionQ33850539
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcriptionQ34031653
Yeast Sen1 helicase protects the genome from transcription-associated instability.Q34157855
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cellsQ34188845
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genesQ34242723
RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instabilityQ34242729
R-loop formation is a distinctive characteristic of unmethylated human CpG island promotersQ34258378
Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated RecombinationQ34267573
R loops: from transcription byproducts to threats to genome stabilityQ34271508
Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiationQ34302249
GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription terminationQ34358463
Characterization of monoclonal antibody to DNA.RNA and its application to immunodetection of hybridsQ34384604
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndromeQ34407383
Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chipQ34415765
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instabilityQ34442378
Mechanisms of transcription-coupled DNA repairQ34514438
R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.Q35160930
R-loop-mediated genomic instability is caused by impairment of replication fork progressionQ35393287
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutantsQ35740611
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instabilityQ36148332
Regulation of endonuclease activity in human nucleotide excision repairQ37877050
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instabilityQ38205642
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complexQ42941871
Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genesQ42965264
NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack.Q45079199
AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutationQ46531711
Interdependence between Transcription and mRNP Processing and Export, and Its Impact on Genetic StabilityQ61827948
Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitroQ73794379
A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicingQ80204773
P433issue6
P921main subjectgenome stabilityQ98655700
P304page(s)777-785
P577publication date2014-11-26
P1433published inMolecular CellQ3319468
P1476titleTranscription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
P478volume56

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