IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis

scientific article

IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI0214685
10.1172/JCI14685
P932PMC publication ID150933
P698PubMed publication ID11927620

P50authorRaj K BatraQ40609588
P2093author name stringJie Luo
Ling Zhang
Marie D Burdick
Robert M Strieter
Min Huang
Michael P Keane
Steven M Dubinett
Sherven Sharma
Mariam Dohadwala
Brian Gardner
Li X Zhu
Ying Q Lin
P2860cites workIL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanismsQ70916487
Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lungQ71939261
Unraveling pulmonary fibrosis: the bleomycin modelQ72730906
Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disordersQ73071043
Interferon gamma-1b for the treatment of idiopathic pulmonary fibrosisQ73098389
IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesisQ73160807
Pulmonary fibrosis: pathways are slowly coming into lightQ73716268
TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotypeQ73802913
TGF-beta signal transductionQ22003891
Transforming growth factor beta in tissue fibrosisQ28239292
Stimulation of B-cell progenitors by cloned murine interleukin-7Q28294062
PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosisQ28359718
Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in miceQ28362073
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in miceQ33853415
Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats.Q34170199
Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expressionQ34371002
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chainQ34389330
A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cellsQ34393054
Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamstersQ35533319
Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell-dependentQ35788056
Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosisQ35796092
Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in miceQ36287478
Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activitiesQ36348799
Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammationQ36356735
Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosisQ37558464
Pulmonary fibrosis: a cellular overreaction or a failure of communication?Q39910045
Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.Q40968846
Murine Strain Differences in Acute Lung Injury and Activation of Poly(ADP-ribose) Polymerase by In Vitro Exposure of Lung Slices to BleomycinQ41078753
Synergistic effects of IL-7 and IL-12 on human T cell activation.Q41345595
Down-regulation of murine fibrosarcoma transforming growth factor-beta 1 expression by interleukin 7.Q41349694
Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2.Q41508794
Down-regulation of macrophage transforming growth factor-beta messenger RNA expression by IL-7.Q41508890
Alteration of transforming growth factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosisQ42856418
Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycinQ43545284
Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastatQ43558010
Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expressionQ43606201
Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblastsQ43701879
Regulation of human T cell proliferation by IL-7.Q45040601
Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosisQ46176836
Multiple cytokine secretion by IL-7-stimulated human T cellsQ52070416
Differential responses of collagen and glycosaminoglycan syntheses and cell proliferation to exogenous transforming growth factor beta 1 in the developing mouse skin fibroblasts in culture.Q52171256
Idiopathic Pulmonary FibrosisQ56804123
Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosisQ61942161
Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradicationQ64381013
Effect of IL-7 on the growth of fetal thymocytes in cultureQ69741055
Murine thymocytes proliferate in direct response to interleukin-7Q69743066
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectpulmonary fibrosisQ32446
P304page(s)931-937
P577publication date2002-04-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleIL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis
P478volume109

Reverse relations

cites work (P2860)
Q36007436Aberrant mucosal mast cell protease expression in the enteric epithelium of nematode-infected mice lacking the integrin alphavbeta6, a transforming growth factor-beta1 activator
Q38448525Acute exacerbation of idiopathic pulmonary fibrosis-a review of current and novel pharmacotherapies
Q47936492Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
Q43848397Attenuated TGF-β1 responsiveness of dendritic cells and their precursors in atopic dermatitis
Q35570990Bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer
Q37350899Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients
Q24811367CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Q38259227Cellular and Molecular Mediators of Intestinal Fibrosis
Q28538913Chemo-immunotherapy with oxaliplatin and interleukin-7 inhibits colon cancer metastasis in mice
Q64057171Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
Q34448187Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts
Q33890498Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling
Q35017833Complex cytokine regulation of tissue fibrosis
Q35916001Complex regulation of pulmonary inflammation and fibrosis by CCL18
Q53688060Coupled Immunological and Biomechanical Model of Emphysema Progression.
Q36989934Current and emerging drugs for idiopathic pulmonary fibrosis
Q35628568Disorders of lung matrix remodeling
Q38413705ELYPSE-7: a randomized placebo-controlled phase IIa trial with CYT107 exploring the restoration of CD4+ lymphocyte count in lymphopenic metastatic breast cancer patients.
Q33489772Effects of angiotensin on the expression of fibrosis-associated cytokines, growth factors, and matrix proteins in human lung fibroblasts
Q41809246Enhancement of human antigen-specific memory T-cell responses by interleukin-7 may improve accuracy in diagnosing tuberculosis
Q34576622Estrogen deficiency and bone loss: an inflammatory tale
Q37134327Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis
Q53686964FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis.
Q35560901IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP)
Q57209222Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue
Q52930728Inhibition of bleomycin-induced pulmonary fibrosis by bone marrow-derived mesenchymal stem cells might be mediated by decreasing MMP9, TIMP-1, INF-γ and TGF-β.
Q34646946Interleukin-7 Gene-Modified Dendritic Cells Reduce Pulmonary Tumor Burden in Spontaneous Murine Bronchoalveolar Cell Carcinoma
Q38756413Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells
Q37989867Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival
Q43836223Interleukin-7 expression in tears and orbital tissues of patients with Graves' ophthalmopathy.
Q54597201Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts.
Q37440802Keloid scarring: bench and bedside
Q92326722Kinetics of Tear Fluid Proteins after Endothelial Keratoplasty and Predictive Factors for Recovery from Corneal Haze
Q36029120Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts
Q31132024MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis
Q46149384Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity
Q89622156Myeloid-derived suppressor cell-dependent inhibition of B cell responses in non-small cell lung cancer
Q36749464New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy.
Q47680876Polymorphisms of the TGF-beta1 promoter in tight skin (TSK) mice.
Q38012228Post-translational regulation of TGF-β receptor and Smad signaling.
Q39026435Posttranslational Regulation of Smads
Q33775800Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma
Q33650035Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection
Q39029996Regulation of TGF-β Family Signaling by Inhibitory Smads.
Q34437606Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
Q37978237Role of T cells in ovariectomy induced bone loss--revisited
Q35769939Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection
Q35170428Role of tissue stroma in cancer cell invasion
Q37323342Signaling cross-talk between TGF-beta/BMP and other pathways
Q35779047Smad3 as a mediator of the fibrotic response
Q35653943Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling
Q35813675Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury
Q64057500Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis
Q35868950T cells and post menopausal osteoporosis in murine models
Q34079698T cells: critical bone regulators in health and disease
Q37337325TGF-β induces the differentiation of human CXCL13-producing CD4(+) T cells.
Q29036999TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia
Q46113966TGF-β1 Signaling and Tissue Fibrosis
Q35083097The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis
Q34143343The immune system and bone
Q37158392Transforming growth factor beta1-mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 t
Q64938035microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model.

Search more.