The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes

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The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003463
P932PMC publication ID3708883
P698PubMed publication ID23853586
P5875ResearchGate publication ID249322247

P2093author name stringAndrew D Yurochko
Maciej T Nogalski
Emily V Stevenson
Gary C T Chan
Donna K Collins-McMillen
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Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolatesQ57275303
Endocytosis of GABAB receptors modulates membrane excitability in the single-celled organism ParameciumQ57375278
N-hydroxysulfosuccinimide active esters: bis(N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkersQ59382817
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Paxillin interactionsQ28143276
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosisQ28235164
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Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
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Virus entry by endocytosisQ29619724
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
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How does ATP hydrolysis control actin's associations?Q30453201
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Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1.Q33788855
HCMV spread and cell tropism are determined by distinct virus populationsQ33798083
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Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathwayQ33843108
Mechanism of thrombin-induced angiogenesisQ34129745
Oncomodulation by human cytomegalovirus: novel clinical findings open new roadsQ34145201
Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropismQ34212879
Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusionQ34301880
Coding potential of laboratory and clinical strains of human cytomegalovirusQ34388908
Do pathogens accelerate atherosclerosis?Q34389205
Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entryQ34487786
A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factorQ34496532
Epidermal growth factor receptor is a cellular receptor for human cytomegalovirusQ34535736
Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell cultureQ34642568
The mononuclear phagocyte system revisited.Q34960983
Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogensQ35120164
Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMVQ35140023
RhoA and ROCK promote migration by limiting membrane protrusionsQ40672013
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Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitroQ41216210
Latent and persistent infections of monocytes and macrophagesQ41454448
Human cytomegalovirus cell tropism and pathogenesisQ41454454
Viral manipulations of the actin cytoskeleton.Q41462600
Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surfaceQ41597223
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Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropismQ41839444
Early events in the infection of human B lymphocytes by Epstein-Barr virus: The internalization processQ41919826
Entry of human cytomegalovirus into retinal pigment epithelial and endothelial cells by endocytosisQ41923033
Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.Q42051351
Protein pUL128 of human cytomegalovirus is necessary for monocyte infection and blocking of migrationQ42081310
Activation of protein kinase C enhances the infection of endothelial cells by human cytomegalovirus.Q42439181
Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cellsQ42812456
Role of human cytomegalovirus UL131A in cell type-specific virus entry and releaseQ43647271
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Integrin alphavbeta3 is a coreceptor for human cytomegalovirusQ35865693
The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infectionQ35887796
Paxillin: adapting to changeQ35895201
Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistenceQ35914507
The interplay between Src and integrins in normal and tumor biologyQ35920891
Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptakeQ36323991
Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrinsQ36535574
Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriersQ36629215
Epstein-Barr virus enters B cells and epithelial cells by different routesQ36697940
HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: evidence for cell type-specific receptorsQ36893722
Mitogenic signaling pathways induced by G protein-coupled receptorsQ36929839
Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophageQ37040044
Entry route of HCMV into endothelial cellsQ37059966
Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen speciesQ37094609
PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytesQ37095286
Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene inductionQ37219576
Cytomegalovirus cell tropism.Q37219958
NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytesQ37329260
Dictyostelium discoideum paxillin regulates actin-based processesQ37345269
Functions of actin in endocytosisQ37416049
Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistenceQ37422612
Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domainQ37593516
Is HCMV a tumor promoter?Q37805181
Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells.Q39020960
Two clinical isolates and the Toledo strain of cytomegalovirus contain endothelial cell tropic variants that are not present in the AD169, Towne, or Davis strainsQ39199329
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases.Q39581979
Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infectionQ39582163
Structure of adenovirus complexed with its internalization receptor, alphavbeta5 integrinQ39595406
Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrinQ39804477
Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains.Q39872953
Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infectionQ39950845
Cytomegalovirus in Semen: Observations in Selected PopulationsQ39957658
Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytesQ39960937
Cytomegalovirus and atherosclerosisQ40375291
Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitiveQ40536152
Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration Is Mediated by Focal Adhesion Kinase and SrcQ40631906
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P304page(s)e1003463
P577publication date2013-07-11
P1433published inPLOS PathogensQ283209
P1476titleThe HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes
P478volume9

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