Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins

scientific article published on 16 December 2015

Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01994-15
P932PMC publication ID4810730
P698PubMed publication ID26676786

P2093author name stringJung Heon Kim
Andrew D Yurochko
Maciej T Nogalski
Emily V Stevenson
Gary C Chan
Donna Collins-McMillen
Joshua R Caskey
Stephen J Cieply
P2860cites workSpecific involvement of caspases in the differentiation of monocytes into macrophagesQ24312229
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2Q24563123
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsQ27683708
Old, new and emerging functions of caspasesQ27686885
Prolonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expressionQ28193489
Cytomegalovirus and cancer of the prostate: in vitro transformation of human cellsQ28275361
Cytomegalovirus infection in the normal hostQ28286404
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motilityQ33563932
Cytomegalovirus (CMV) DNA load is an independent predictor of CMV disease and survival in advanced AIDSQ33818170
Host defense, viruses and apoptosisQ34225877
Do pathogens accelerate atherosclerosis?Q34389205
Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entryQ34487786
The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytesQ34819531
The mononuclear phagocyte system revisited.Q34960983
Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancerQ34991284
Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMVQ35140023
The BCL-2 family reunionQ35568029
Cell death suppressors encoded by cytomegalovirus.Q35788798
Host defense response to cytomegalovirus in the central nervous system. Predominance of the monocyteQ35816101
The human cytomegalovirus virion possesses an activated casein kinase II that allows for the rapid phosphorylation of the inhibitor of NF-kappaB, IkappaBalphaQ35857513
Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistenceQ35914507
Cell death suppression by cytomegalovirusesQ36103553
Human cytomegalovirus induction of a unique signalsome during viral entry into monocytes mediates distinct functional changes: a strategy for viral disseminationQ36232248
Human cytomegalovirus stimulates monocyte-to-macrophage differentiation via the temporal regulation of caspase 3.Q36276722
Infection in the renal transplant recipient.Q51198330
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.Q52546411
Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer.Q53235691
Cytomegalovirus retinitis in AIDS patients: influence of cytomegaloviral load on response to ganciclovir, time to recurrence and survivalQ57181705
Cytomegalovirus infection after renal transplantationQ68551354
Observations on human monocyte kinetics after pulse labelingQ70420450
High rate of concurrent genital infections with human cytomegalovirus and human papillomaviruses in cervical cancer patientsQ70466647
MCL-1, a member of the BLC-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferationQ70998037
Potential role of human cytomegalovirus and p53 interaction in coronary restenosisQ72041267
Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditionsQ72996076
CMV as an exacerbating agent in transplant vascular sclerosis: potential immune-mediated mechanisms modelled in vitroQ73279243
Cell cycle-independent down-regulation of BCL-2 protein expression in differentiating HL-60 cellsQ73449020
Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expressionQ77320669
Human cytomegalovirus as a direct pathogen: correlation of multiorgan involvement and cell distribution with clinical and pathological findings in a case of congenital inclusion diseaseQ78052127
Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancerQ78549918
HCMV activates PI(3)K in monocytes and promotes monocyte motility and transendothelial migration in a PI(3)K-dependent mannerQ79985282
Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrinsQ36535574
Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriersQ36629215
Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancerQ36751571
Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophageQ37040044
PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytesQ37095286
Human cytomegalovirus modulation of signal transductionQ37219989
NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytesQ37329260
Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistenceQ37422612
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoterQ37422869
HCMV reprogramming of infected monocyte survival and differentiation: a Goldilocks phenomenonQ37611836
Virus infections after transplantation in man. Brief reviewQ37658280
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.Q37826384
Reproductive and infectious risk factors for invasive cervical cancer in Taiwan.Q37877135
Impact of cytomegalovirus infection on organ transplant recipientsQ37897931
Prevention of cellular suicide by cytomegalovirusesQ38064278
Staying alive: cell death in antiviral immunityQ38207187
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.Q38332509
EGFR signaling defines Mcl⁻1 survival dependency in neuroblastomaQ38901662
MCL-1 dependency of cisplatin-resistant cancer cellsQ38967669
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemiaQ39405994
Infectious Complications of Human Bone Marrow TransplantationQ39786451
Auditory and visual defects resulting from symptomatic and subclinical congenital cytomegaloviral and toxoplasma infectionsQ40068504
Human Cytomegalovirus Infection and Disorders of the Nervous SystemQ40140271
Cytomegalovirus and human cancerQ40142738
Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicityQ40150549
From the National Institutes of Health. Summary of a workshop on cytomegalovirus infections during organ transplantationQ40232299
Cytomegalovirus Pneumonia After Human Marrow TransplantationQ40307841
Cytomegalovirus and atherosclerosisQ40375291
Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells.Q40449316
Cytomegalovirus infection in immunocompetent patientsQ40543447
Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration Is Mediated by Focal Adhesion Kinase and SrcQ40631906
Latent and persistent infections of monocytes and macrophagesQ41454448
Human cytomegalovirus cell tropism and pathogenesisQ41454454
Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropismQ41839444
Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-upQ41935840
Congenital cytomegalovirus infection: a fifteen year perspectiveQ41938603
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Q42064781
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitroQ44559968
Human cytomegalovirus infection and expression in human malignant glioma.Q44991512
Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study GroupQ45874436
Cytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy findingsQ46358329
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cellsQ46532001
Cytomegalovirus preferentially infects a monocyte derived macrophage/microglial cell in human brain cultures: neuropathology differs between strainsQ48705058
Symptomatic congenital cytomegalovirus. Disorders of language, learning, and hearingQ49079081
The outcome of congenital cytomegalovirus infection in relation to maternal antibody statusQ50539344
Trends in infectious diseases and cancers among persons dying of HIV infection in the United States from 1987 to 1992.Q50593906
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.Q51037841
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
P304page(s)2356-2371
P577publication date2015-12-16
P1433published inJournal of VirologyQ1251128
P1476titleHuman Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins
P478volume90

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cites work (P2860)
Q91975369Cytomegalovirus Latency and Reactivation: An Intricate Interplay With the Host Immune Response
Q57065814HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection?
Q38793369HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors
Q41918747HCMV utilizes a non-traditional STAT1 activation cascade via signaling through EGFR and integrins to efficiently promote the motility, differentiation, and polarization of infected monocytes
Q64241945Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth
Q52351840Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.
Q39100413Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells.
Q57469888Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency
Q58734475Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation
Q52691329New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.
Q40480154Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta.
Q41922877The Bcl-2 Family in Host-Virus Interactions.
Q98771314The Differentiation of Human Cytomegalovirus Infected-Monocytes Is Required for Viral Replication
Q37161687Viral binding-induced signaling drives a unique and extended intracellular trafficking pattern during infection of primary monocytes
Q51737478Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses.

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