New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.

scientific article published on 9 January 2018

New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection. is …
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scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.24102
P932PMC publication ID5805549
P698PubMed publication ID29467963

P50authorIrena Baranowska-BosiackaQ42305549
Dariusz ChlubekQ41532339
Izabela GutowskaQ59541582
Jan KorbeckiQ59691236
Agnieszka ŁukomskaQ59691284
Marta GoschorskaQ60968412
Dariusz JeżewskiQ94555958
P2093author name stringAnna Lubkowska
Ireneusz Kojder
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Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.Q37706595
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Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancerQ37772662
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Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric functionQ37872839
Targeting sphingosine-1-phosphate receptors in cancerQ37894772
Tumor-associated neutrophils: friend or foe?Q37994480
Diverse immune evasion strategies by human cytomegalovirusQ37997733
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Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiformeQ38262132
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Human cytomegalovirus riding the cell cycle.Q38379991
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Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.Q38802701
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The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferationQ39959907
Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.Q39972447
Expression and putative functions of GDF-15, a member of the TGF-beta superfamily, in human glioma and glioblastoma cell linesQ39972860
Human cytomegalovirus inhibits cytokine-induced macrophage differentiationQ39992541
Seroprevalence and risk factors of human cytomegalovirus infection in the eastern Chinese populationQ39997413
Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivoQ39997572
Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristicsQ40011425
Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophagesQ40029162
GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitroQ40032613
S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.Q40033973
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.Q40102693
Ecto-5'-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell lineQ40104116
Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasivenessQ40115765
Distribution of neurotensin and its receptor in the central nervous systemQ40134265
The in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cellsQ40212349
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted VaccinationQ40241735
Biophysical characteristics of neurotensin polyplex for in vitro and in vivo gene transfectionQ40274640
Radionuclide imaging of small-cell lung cancer (SCLC) using 99mTc-labeled neurotensin peptide 8-13.Q40276413
S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.Q40279381
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.Q40280838
Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgammaQ40300178
Increasing of HER2 membranar density in human glioblastoma U251MG cell line established in a new nude mice modelQ40366512
A paired comparison between glioblastoma "stem cells" and differentiated cellsQ40373080
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell linesQ40384186
Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirusQ40444834
Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell lineQ40514985
Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomasQ40554806
Down-regulation of HLA-G1 cell surface expression in human cytomegalovirus infected cells.Q40608026
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradationQ40609266
FTY720 attenuates excitotoxicity and neuroinflammation.Q40613316
CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor CellsQ40619963
Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice.Q40673595
EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation.Q40709419
Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.Q40722521
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytesQ40778287
Lysophospholipids increase interleukin-8 expression in ovarian cancer cellsQ40809174
Ganciclovir concentrations in the cerebral extracellular space after valganciclovir treatment; a case studyQ40869992
Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphateQ40870274
Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection.Q40875274
Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function.Q40925445
Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.Q40927773
Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in GlioblastomaQ41074007
Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against SepsisQ41096093
Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cellsQ41130088
The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1.Q41221061
CD133 Regulates IL-1β Signaling and Neutrophil Recruitment in GlioblastomaQ41288638
Stimulatory effects of human cytomegalovirus tegument protein pp71 lead to increased expression of CCL2 (monocyte chemotactic protein-1) during infectionQ41356756
A Time-Based and Intratumoral Proteomic Assessment of a Recurrent Glioblastoma MultiformeQ41481825
Growth differentiation factor 15 promotes blood vessel growth by stimulating cell cycle progression in repair of critical-sized calvarial defectQ41490097
Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responsesQ41581885
Prognostic role of neutrophil lymphocyte ratio in patients with gliomaQ41708897
HCMV induces dysregulation of glutamate uptake and transporter expression in human fetal astrocytesQ41712134
The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesisQ41770473
Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma.Q52846347
Cytomegalovirus-specific regulatory and effector T cells share TCR clonality--possible relation to repetitive CMV infections.Q52891818
The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation.Q52904194
SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.Q52955080
Macrophage inhibitory cytokine-1 stimulates proliferation of human umbilical vein endothelial cells by up-regulating cyclins D1 and E through the PI3K/Akt-, ERK-, and JNK-dependent AP-1 and E2F activation signaling pathways.Q53175353
Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.Q53186527
Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages/microglia.Q53236986
Superficial spreading malignant melanoma in a patient on fingolimod therapy for multiple sclerosis.Q53274535
CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury.Q53306828
Chemokines in vascular remodeling.Q53555481
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.Q53579438
Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors.Q53621449
Simultaneous generation of cytomegalovirus-specific CD8+ and CD4+ T lymphocytes by use of dendritic cells comodified with pp65 mRNA and pp65 protein.Q53650569
Phase II trial of dacomitinib, a pan-human EGFR tyrosine kinase inhibitor, in recurrent glioblastoma patients with EGFR amplification.Q53838239
Transfection of dendritic cells with in vitro-transcribed CMV RNA induces polyclonal CD8+- and CD4+-mediated CMV-specific T cell responses.Q54321271
FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway.Q54334399
Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9.Q54392759
Glioma-initiating cells: A predominant role in microglia/macrophages tropism to gliomaQ54402893
Differential responses of human microglia and blood-derived myeloid cells to FTY720.Q54412239
Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury.Q54577209
SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/β-catenin signaling pathway.Q55027066
Glioblastoma multiforme stem cells.Q55084777
Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirus-specific T-cells in patients with glioblastoma multiforme.Q55462188
IL-10 and TGF-β2 are overexpressed in tumor spheres cultured from human gliomas.Q55463659
Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1.Q55463916
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398.Q55475169
Flow cytometric characterization of tumor-associated macrophages in experimental gliomas.Q55475809
Signal transduction of sphingosine-1-phosphate G protein-coupled receptors.Q55513682
Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: Antiviral implicationsQ56965208
Decreased cytomegalovirus expression following proinflammatory cytokine treatment of primary human astrocytesQ56965230
Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarizationQ57200899
Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expressionQ59466639
Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesisQ30417313
Characterization of a sphingosine 1-phosphate receptor antagonist prodrugQ30425227
Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophagesQ30436091
Virus-encoded homologs of cellular interleukin-10 and their control of host immune functionQ30436621
Chemokines as mediators of neovascularizationQ30438032
Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathwayQ30441092
Diverse roles of neurotensin agonists in the central nervous systemQ30456105
Cytomegalovirus-encoded beta chemokine promotes monocyte-associated viremia in the hostQ30478992
Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastomaQ30491742
Extent of resection in patients with glioblastoma: limiting factors, perception of resectability, and effect on survival.Q30565662
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive propertiesQ30572687
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trialQ30789784
Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data.Q30794277
SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cellsQ31942539
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cellsQ31952928
In vitro and in vivo evaluation of new radiolabeled neurotensin(8-13) analogues with high affinity for NT1 receptorsQ31970611
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptorQ33266079
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.Q33271908
Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomideQ33341259
Temozolomide in radio-chemotherapy combined treatment for newly-diagnosed glioblastoma multiforme: phase II clinical trialQ33359703
A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma.Q33391296
Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motilityQ33410786
Clinical outcome of an alternative fotemustine schedule in elderly patients with recurrent glioblastoma: a mono-institutional retrospective studyQ33432135
HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activationQ33572274
Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1.Q33607086
Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cellsQ33664082
Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells.Q33761585
Synthesis and Evaluation of 64Cu-DOTA-NT-Cy5.5 as a Dual-Modality PET/Fluorescence Probe to Image Neurotensin Receptor-Positive Tumor.Q33769389
Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress BlockageQ33770196
Genetic instability and darwinian selection in tumoursQ33804007
Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirusQ33810440
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosisQ33810559
The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophagesQ33826894
Human cytomegalovirus chemokine receptor gene US28 is transcribed in latently infected THP-1 monocytesQ33842393
Neurotensin increases endogenous glutamate release in rat cortical slicesQ62965080
Neuropeptides modulating macrophage functionQ70185582
Neurotensin stimulates neutrophil adherence to bronchial epithelial cells in vitroQ71040678
Neurotensin modulates human neutrophil locomotion and phagocytic capabilityQ71792602
Immunosuppressive therapy using FTY720 combined with tacrolimus in rat liver transplantationQ73414391
Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide productionQ73426568
Immunosuppressive action of FTY720 for renal allograft a rat modelQ74617211
Dose-dependent study of a novel immunosuppressant, FTY720, with the canine renal allograft transplantation modelQ74617278
Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3Q79853765
FTY720 application following isolated warm liver ischemia improves long-term survival and organ protection in a mouse modelQ79959742
Long-term effect of FTY720 on lymphocyte count and islet allograft survival in miceQ80261117
Synthesis and biological activity of stable branched neurotensin peptides for tumor targetingQ80981625
Expression of human CXCR2 in murine neutrophils as a model for assessing cytomegalovirus chemokine vCXCL-1 function in vivoQ81215279
CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosisQ82283387
MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblastsQ82414820
Latency and reactivation of human cytomegalovirusQ83946800
The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitroQ84108192
FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD miceQ84220581
GDF-15 promotes angiogenesis through modulating p53/HIF-1α signaling pathway in hypoxic human umbilical vein endothelial cellsQ84578298
The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4Q87248985
Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitmentQ87412863
Human cytomegalovirus subverts the functions of monocytes, impairing chemokine-mediated migration and leukocyte recruitment.Q41876583
Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial.Q41926865
Modeling cytomegalovirus infection in mouse tumor modelsQ41929176
Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progressionQ41966417
Glioblastoma following treatment with fingolimod for relapsing-remitting multiple sclerosisQ42011721
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.Q45086529
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survivalQ45327856
The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophagesQ45720263
Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markersQ45735279
Decreased neutrophil adhesion to human cytomegalovirus-infected retinal pigment epithelial cells is mediated by virus-induced up-regulation of Fas ligand independent of neutrophil apoptosisQ45740172
Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions.Q45924633
The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.Q45956195
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.Q46017179
Neurotensin enhances IL-1 production by activated alveolar macrophages.Q46030923
Patients with recurrent glioblastoma multiforme. Initial experience with p-[(131)I]iodo-L-phenylalanine and external beam radiation therapy.Q46127268
Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activationQ46143632
Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacyQ46202289
Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience.Q46231452
PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signalingQ46365844
S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homingQ46399943
Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiformeQ46412809
Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in miceQ46613202
Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analoguesQ46668631
Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.Q46709590
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.Q46751827
Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cellsQ46759430
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expressionQ46820182
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.Q46869214
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularizationQ46882679
A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinomaQ46979728
Anorexia and weight loss in glioma patientsQ47187804
Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migrationQ47806925
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligandQ47897710
Cancer-promoting mechanisms of tumor-associated neutrophilsQ47920259
Is there a change in cytomegalovirus seroepidemiology in Spain?Q47974547
Soluble human leukocyte antigen G5 polarizes differentiation of macrophages toward a decidual macrophage-like phenotype.Q48022161
GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimerQ48219910
Production and neuroprotective functions of fractalkine in the central nervous systemQ48258224
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusionQ48268373
The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patientsQ48298035
Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?Q48301491
Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release.Q48382115
Human cytomegalovirus infection reduces surface CCR5 expression in human microglial cells, astrocytes and monocyte-derived macrophagesQ48428929
Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcomeQ48573837
Radiogenomics to characterize regional genetic heterogeneity in glioblastomaQ48582092
Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells.Q48649561
Peritumoral angiogenesis around primary and metastatic brain neoplasms. Morphometric analysisQ48730491
Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusionQ48819256
CD4+Foxp3- type 1 regulatory T cells in glioblastoma multiforme suppress T cell responses through multiple pathways and are regulated by tumor-associated macrophages.Q50617004
High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.Q50981100
The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.Q51320013
Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells.Q51497442
The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway.Q51640897
Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.Q51676055
A Supplemented High-Fat Low-Carbohydrate Diet for the Treatment of Glioblastoma.Q52145569
S1PR5 is pivotal for the homeostasis of patrolling monocytes.Q52639389
Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3pQ36493809
Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169Q36499722
Human cytomegalovirus transcriptome activity differs during replication in human fibroblast, epithelial and astrocyte cell linesQ36523245
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastomaQ36523499
The role of neurotensin in central nervous system pathophysiology: what is the evidence?Q36544566
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivoQ36545028
Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.Q36557481
Neurotensin and growth of normal and neoplastic tissuesQ36563759
Epidemiology and molecular pathology of gliomaQ36577353
The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancerQ36592451
The multifaceted roles of chemokines in malignancyQ36611120
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastomaQ36650859
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Q36673354
GDF15 promotes EMT and metastasis in colorectal cancerQ36729546
Molecular heterogeneity of glioblastomas: does location matter?Q36729562
Human Cytomegalovirus-Encoded Human Interleukin-10 (IL-10) Homolog Amplifies Its Immunomodulatory Potential by Upregulating Human IL-10 in MonocytesQ36736415
Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family ProteinsQ36736892
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signalQ36804936
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signalingQ36873593
Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment.Q36900640
The S phase of the cell cycle and its perturbation by human cytomegalovirusQ36901744
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cellsQ36907370
Control of glioma cell migration and invasiveness by GDF-15Q36946604
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin AQ36981029
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasivenessQ36982983
Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiformeQ37022369
Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitroQ37025429
Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophageQ37040044
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cellsQ37081881
A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus - tumor associationQ37085029
Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomasQ37109246
The human cytomegalovirus.Q35143349
Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patientsQ35154148
Differential distribution of erbB receptors in human glioblastoma multiforme: expression of erbB3 in CD133-positive putative cancer stem cellsQ35214798
The two faces of interferon-γ in cancerQ35269015
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interactionQ35351861
Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.Q35476157
Sphingosine kinase inhibitors and cancer: seeking the golden sword of HerculesQ35501532
The role of metabolic therapy in treating glioblastoma multiformeQ35519662
Human cytomegalovirus gene expression in long-term infected glioma stem cells.Q35535809
Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer.Q35568516
Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activationQ35570705
Neurotensin branched peptide as a tumor-targeting agent for human bladder cancer.Q35578796
Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell PopulationsQ35748846
Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastomaQ35759682
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor responseQ35779256
Murine cytomegalovirus immediate-early promoter directs astrocyte-specific expression in transgenic miceQ35786286
Generation and metabolism of bioactive sphingosine-1-phosphateQ35839009
Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastomaQ35845241
CCL5, CCR1 and CCR5 in murine glioblastoma: immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5Q35911313
A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagyQ35966272
VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptorsQ35977376
Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in MiceQ36012100
Genetic analysis of cytomegalovirus in malignant gliomasQ36086786
Evaluation of DOTA-chelated neurotensin analogs with spacer-enhanced biological performance for neurotensin-receptor-1-positive tumor targetingQ36122563
Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.Q36178557
Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus PersistenceQ36214992
Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote AngiogenesisQ36281674
Association between human cytomegalovirus infection and histone acetylation level in various histological types of gliomaQ36336070
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factorsQ36342909
Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitisQ36348385
Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patientsQ36349348
Cancer CXC chemokine networks and tumour angiogenesisQ36410717
Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15.Q36421073
The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitmentQ36473213
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
CytomegalovirusQ6946
P304page(s)7219-7270
P577publication date2018-01-09
P1433published inOncotargetQ1573155
P1476titleNew extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.
P478volume9

Reverse relations

cites work (P2860)
Q98166036Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools
Q89552038Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks
Q58766021The Pathophysiology of Post-Traumatic Glioma

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