Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src

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Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...871035I
P356DOI10.1371/JOURNAL.PONE.0071035
P932PMC publication ID3724807
P698PubMed publication ID23923048
P5875ResearchGate publication ID255696126

P50authorTerrence D. MulhernQ54965497
Danny M. HattersQ45293201
P2093author name stringSevgi Irtegun
Rebecca J Wood
Angelique R Ormsby
P2860cites workA phosphotyrosine displacement mechanism for activation of Src by PTPalphaQ22253266
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAsQ24537510
Crystal structures of c-Src reveal features of its autoinhibitory mechanismQ27618504
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitorQ27618507
Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylationQ27734052
Three-dimensional structure of the tyrosine kinase c-SrcQ27734749
Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.Q50681563
Characterization of purified pp60c-src protein tyrosine kinase from human plateletsQ67663346
Determination of the sedimentation coefficient distribution by least-squares boundary modelingQ74145637
The green fluorescent proteinQ27860492
Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2Q28568668
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cellsQ29547331
Activation of the Src family kinase Hck without SH3-linker releaseQ30160117
Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinasesQ30160119
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activationQ30160222
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domainQ30165193
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivoQ30165458
Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligandQ30175264
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.Q30194001
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.Q30194623
Far-red fluorescent tags for protein imaging in living tissuesQ30495187
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamicsQ30499765
Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylationQ33580628
Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.Q33967338
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylationQ34166097
Tyr527 is phosphorylated in pp60c-src: implications for regulationQ34383180
The interplay between Src and integrins in normal and tumor biologyQ35920891
Association of p60c-src with endosomal membranes in mammalian fibroblastsQ36533201
pp60c-src variants containing lesions that affect phosphorylation at tyrosines 416 and 527.Q36759826
Regulation by the autophosphorylation site in overexpressed pp60c-srcQ36847836
Low level of cellular protein phosphorylation by nontransforming overproduced p60c-srcQ36888845
A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicityQ36903823
Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60srcQ36910596
Evidence the pp60src, the product of the Rous sarcoma virus src gene, undergoes autophosphorylationQ36936361
Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the proteinQ36955434
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.Q39481540
Effects of Src kinase inhibition induced by dasatinib in non-small cell lung cancer cell lines treated with cisplatin.Q39782838
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.Q41083682
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoproteinQ41326706
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-srcQ41713730
Conformational states of the kinase Lck regulate clustering in early T cell signalingQ42679142
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membraneQ42823071
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-srcQ44049774
Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of huQ44441901
Structural characterization of the natively unfolded N-terminal domain of human c-Src kinase: insights into the role of phosphorylation of the unique domain.Q45972692
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)e71035
P577publication date2013-07-26
P1433published inPLOS OneQ564954
P1476titleTyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src
P478volume8

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cites work (P2860)
Q57287935A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src
Q35658526Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src
Q36250960Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells
Q54983881Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2.
Q41885536GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation
Q39508428Iron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cells
Q37622574Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell
Q38797416Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration
Q28830232Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet's Disease
Q38520262Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases

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