Regulation of G protein-coupled receptor signaling by scaffold proteins

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Regulation of G protein-coupled receptor signaling by scaffold proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/01.RES.0000037000.74258.03
P698PubMed publication ID12386143

P50authorRobert LefkowitzQ80910
P2093author name stringRandy A Hall
P2860cites workIndependent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors.Q46069724
Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complexQ47070308
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascadeQ47070943
The visual G protein of fly photoreceptors interacts with the PDZ domain assembled INAD signaling complex via direct binding of activated Galpha(q) to phospholipase cbetaQ47071375
Protein kinase C inhibitor proteins. Purification from sheep brain and sequence similarity to lipocortins and 14-3-3 proteinQ48259445
Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slicesQ48418431
Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding siteQ49110267
Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinaseQ49133448
Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1ReceptorQ57630557
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Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2Q58450964
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Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channelsQ73011082
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Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptorsQ22007971
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Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteinsQ22008754
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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2Q22253360
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activityQ24290364
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteinsQ24290626
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1Q24291215
beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95Q24291617
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivoQ24292193
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinasesQ24303438
beta-Arrestin: a protein that regulates beta-adrenergic receptor functionQ24305145
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interactionQ24309146
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchangeQ24310009
Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing ProteinsQ24310521
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteinsQ24316901
A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion ProteinsQ24321831
FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinaseQ24323995
TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cellsQ36293804
Model systems for the study of seven-transmembrane-segment receptorsQ36417986
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complexQ37273521
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.Q38302685
Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domainsQ40803259
Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring functionQ40901767
Angiotensin II signalling events mediated by tyrosine phosphorylationQ41087624
Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Cross-talk between angiotensin II and interleukin-6 nuclear signalingQ41312650
The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.Q43578243
Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): pharmacology, surface expression, and differential effects of Homer-1a and Homer-1cQ43759581
Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responsesQ46057937
Interaction of the protein kinase Raf-1 with 14-3-3 proteinsQ24329122
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activityQ24515074
Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured NeuronsQ24522731
Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1Q24533305
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2AQ24554283
Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin AQ24604923
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffoldsQ24605173
The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2Q24609951
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosisQ24651529
PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid systemQ24672899
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteinsQ24673877
Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin FamilyQ24678695
Signaling Through Scaffold, Anchoring, and Adaptor ProteinsQ28131792
Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1Q28137763
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3Q28138462
beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptorsQ28139083
Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulationQ28140914
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signalingQ28141060
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteinsQ28141190
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosisQ28141212
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1Q28142235
The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pitsQ28142257
Homer 1b regulates the trafficking of group I metabotropic glutamate receptorsQ28143150
A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptorQ28145098
Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRIQ28145365
Interaction of Vesl-1L/Homer 1c with syntaxin 13Q28145457
Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3Q28189417
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestinQ28190513
Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesinsQ28201977
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein HomerQ28202988
G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95Q28204363
PDZ domains and the organization of supramolecular complexesQ28209906
The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitizationQ28213312
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosisQ28215045
Binding of neuroligins to PSD-95Q28247782
Cloning and characterization of MUPP1, a novel PDZ domain proteinQ28267302
Peptide binding consensus of the NHE‐RF‐PDZ1 domain matches the C‐terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)Q28272686
An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the CytoskeletonQ28277503
Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsQ28278085
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95Q28290055
Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravinQ28293178
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptorQ28301248
Homer: a protein that selectively binds metabotropic glutamate receptorsQ28305877
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transportQ28512887
Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptorQ28565959
Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptorsQ28569381
PICK1 interacts with and regulates PKC phosphorylation of mGLUR7Q28576999
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1Q28581221
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptorQ29618735
Transcriptional responses to polypeptide ligands: the JAK-STAT pathwayQ29620287
Interaction of the calcium-sensing receptor and filamin, a potential scaffolding proteinQ30991287
The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.Q31816068
Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-cateninQ33177665
Interaction of synaptic scaffolding molecule and Beta -catenin.Q33288826
Heptahelical receptor signaling: beyond the G protein paradigm.Q33648620
AKAPs: from structure to functionQ33650483
The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypesQ33860370
Signal transduction: hanging on a scaffold.Q33860503
Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signalingQ33888698
Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelinQ33919351
Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinaseQ33949804
G-protein-independent signaling by G-protein-coupled receptorsQ34046199
Protein-protein interactions at G-protein-coupled receptorsQ34093414
Signaling at zero G: G-protein-independent functions for 7-TM receptorsQ34245417
Scaffolding proteins organize multimolecular protein complexes for sensory signal transductionQ34383944
Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteinsQ36256280
P433issue8
P921main subjectG protein-coupled receptorQ38173
P1104number of pages9
P304page(s)672-680
P577publication date2002-10-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inCirculation ResearchQ2599020
P1476titleRegulation of G protein-coupled receptor signaling by scaffold proteins
P478volume91

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