Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro

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Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/CJI.0B013E318216983D
P932PMC publication ID3094909
P698PubMed publication ID21499130

P50authorSteven RosenbergQ2347448
P2093author name stringPaul F Robbins
Jianping Huang
Yong F Li
Shicheng Yang
Qiong J Wang
Mona El-Gamil
P2860cites workCD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosaQ42976276
Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunityQ43591261
Expression of the murine CD27 ligand CD70 in vitro and in vivo.Q51840742
CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.Q51995040
IL-2 and IL-15 regulate CD154 expression on activated CD4 T cellsQ73567280
Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivoQ79609711
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cellsQ24540135
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimensQ24644442
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesQ24676216
TNF/TNFR family members in costimulation of T cell responsesQ28240053
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletionQ28511040
Tolerance, danger, and the extended familyQ29547532
Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cellsQ30435565
IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cellsQ34430450
Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)Q34732473
Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapyQ34936175
Costimulation of T cells by OX40, 4-1BB, and CD27.Q35145627
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cellsQ35638571
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functionsQ36184396
A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.Q36229330
Adoptive cell therapy for the treatment of patients with metastatic melanomaQ36283034
Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell primingQ36616735
Systemic effects of local radiotherapyQ37539309
Priming of CD8+ T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cellsQ40171970
Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cellsQ40528361
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cellsQ41564337
The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humansQ42456050
P433issue4
P304page(s)327-335
P577publication date2011-05-01
P1433published inJournal of ImmunotherapyQ15763946
P1476titleIrradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro
P478volume34

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cites work (P2860)
Q42003336Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells
Q48223703CD70, a novel target of CAR T-cell therapy for gliomas
Q35674805Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling
Q39398605Gene expression profiling in MOLT-4 cells during gamma-radiation-induced apoptosis.
Q28088598Harnessing the Microbiome to Enhance Cancer Immunotherapy
Q101410475Immune checkpoint expression in HNSCC patients before and after definitive chemoradiotherapy
Q38654155Immunomodulatory effects of radiation: what is next for cancer therapy?
Q58780048In Vivo Irradiation of Mice Induces Activation of Dendritic Cells
Q34389016Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer
Q39365749Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness
Q99602817Radiation therapy enhanced therapeutic efficacy of anti-PD1 against gastric cancer
Q28081611T-cell receptor gene therapy--ready to go viral?
Q41551980The inducible costimulator augments Tc17 cell responses to self and tumor tissue.
Q37518395The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications
Q38726535Tumor associated CD70 expression is involved in promoting tumor migration and macrophage infiltration in GBM.

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