Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy

scientific article

Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.176.12.7726
P932PMC publication ID1532931
P698PubMed publication ID16751420
P5875ResearchGate publication ID7032377

P50authorSteven RosenbergQ2347448
P2093author name stringPaul F Robbins
Jianping Huang
Keith W Kerstann
Yong F Li
Mona El-Gamil
Mojgan Ahmadzadeh
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Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptorsQ28282381
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsQ33831940
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancerQ34194434
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancerQ34536176
T cell anergyQ35019694
Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoidsQ35209017
IL-2, regulatory T cells, and toleranceQ35700529
Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathologyQ36005961
Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regressionQ36327111
Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapyQ36328394
CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell PoolQ36371828
Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formationQ36399059
CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patientsQ36399628
Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis.Q36892603
Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapyQ36908563
Acquisition of immunologic self-toleranceQ38254157
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinaseQ40504374
Signals and signs for lymphocyte responsesQ40620206
Involvement of CD27/CD70 interactions in antigen-specific cytotoxic T-lymphocyte (CTL) activity by perforin-mediated cytotoxicityQ40687538
Engagement of CD27 with its ligand CD70 provides a second signal for T cell activationQ41359863
Interleukin-2, interleukin-15, and their receptorsQ41722182
Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.Q42829457
CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosaQ42976276
Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.Q44999145
CD40 and CD70 co-stimulate a potent in vivo antitumor T cell response.Q48016904
CD25-expressing CD8+ T cells are potent memory cells in old age.Q48948051
Expression of the murine CD27 ligand CD70 in vitro and in vivo.Q51840742
Immune activation modulates hematopoiesis through interactions between CD27 and CD70Q61863476
Reversal of in vitro T cell clonal anergy by IL-2 stimulationQ68181442
Constant-infusion recombinant interleukin-2 in adoptive immunotherapy of advanced cancerQ68815187
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2Q72275233
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivoQ73263520
Expression of CD27 on murine hematopoietic stem and progenitor cellsQ73542908
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectimmunotherapyQ1427096
P304page(s)7726-7735
P577publication date2006-06-01
P1433published inJournal of ImmunologyQ3521441
P1476titleModulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy
P478volume176

Reverse relations

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