Prevention of interleukin-2 withdrawal-induced apoptosis in lymphocytes retrovirally cotransduced with genes encoding an antitumor T-cell receptor and an antiapoptotic protein

scientific article published on 01 September 2010

Prevention of interleukin-2 withdrawal-induced apoptosis in lymphocytes retrovirally cotransduced with genes encoding an antitumor T-cell receptor and an antiapoptotic protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/CJI.0B013E3181E475CD
P932PMC publication ID6390957
P698PubMed publication ID20664359

P50authorSteven RosenbergQ2347448
Anusha KalbasiQ57620683
P2093author name stringRajeev K Shrimali
Dhanalakshmi Chinnasamy
P2860cites workSingle and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functionsQ36713758
Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activityQ36726945
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IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.Q52267043
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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cellsQ24621753
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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosisQ28189945
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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsQ33831940
Dysregulation of apoptosis genes in hematopoietic malignancies.Q34658574
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Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapyQ34936175
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Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primatesQ36183567
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Bcl-2 overexpression enhances tumor-specific T-cell survivalQ36327125
Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell linesQ36327142
Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapyQ36328394
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.Q36371632
P433issue7
P304page(s)672-683
P577publication date2010-09-01
P1433published inJournal of ImmunotherapyQ15763946
P1476titlePrevention of interleukin-2 withdrawal-induced apoptosis in lymphocytes retrovirally cotransduced with genes encoding an antitumor T-cell receptor and an antiapoptotic protein
P478volume33

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cites work (P2860)
Q38227889A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy
Q38178359Adoptive immunotherapy for cancer or viruses
Q27027803Advances in the treatment of metastatic melanoma: adoptive T-cell therapy
Q37851972Cellular immunotherapy for high-grade glioma
Q35149637Classification of current anticancer immunotherapies
Q26995677Genetic engineering with T cell receptors
Q26860657Genetically modified T cells for the treatment of malignant disease
Q28081611T-cell receptor gene therapy--ready to go viral?
Q36887833Trial Watch: Adoptive cell transfer for anticancer immunotherapy
Q42702234Trial Watch: Adoptive cell transfer for anticancer immunotherapy
Q26785545Trial Watch: Adoptive cell transfer for oncological indications
Q36057432Trial Watch: Adoptive cell transfer immunotherapy

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