IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells

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IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/CJI.0B013E3180336787
P932PMC publication ID2174606
P698PubMed publication ID17414320

P50authorSteven RosenbergQ2347448
P2093author name stringPaul A Antony
Mojgan Ahmadzadeh
P2860cites workScurfin (FOXP3) acts as a repressor of transcription and regulates T cell activationQ24291515
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Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cellsQ24298812
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cellsQ24645614
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
A function for interleukin 2 in Foxp3-expressing regulatory T cellsQ28590646
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyQ29619109
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentQ34597933
Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccinationQ34648472
Interleukin-2-dependent mechanisms of tolerance and immunity in vivoQ34655265
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patientsQ34657691
Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapyQ34936175
Human CD4+CD25+ regulatory T cellsQ35703495
High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCTQ35849935
Tolerance, not immunity, crucially depends on IL-2.Q35877199
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.Q36078042
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanomaQ36119828
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralizationQ36402763
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synoviaQ36403785
FOXP3: of mice and men.Q36427333
Immunosuppression in melanoma immunotherapy: potential opportunities for interventionQ36445961
TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cellsQ36924688
Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cellsQ41908906
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivoQ42139164
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ TregsQ42181372
Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanomaQ45287769
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor functionQ47579310
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Q54645452
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cellsQ81357564
P433issue3
P304page(s)294-302
P577publication date2007-04-01
P1433published inJournal of ImmunotherapyQ15763946
P1476titleIL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells
P478volume30