| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Michael W Quick | |
| Robin A J Lester | |||
| P433 | issue | 4 | |
| P921 | main subject | desensitization | Q2700499 |
| P1104 | number of pages | 22 | |
| P304 | page(s) | 457-478 | |
| P577 | publication date | 2002-12-01 | |
| P1433 | published in | Developmental Neurobiology | Q15716734 |
| P1476 | title | Desensitization of neuronal nicotinic receptors | |
| P478 | volume | 53 |
| Q34109947 | 86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization |
| Q34414363 | A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. |
| Q40362619 | A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. |
| Q35982285 | A single administration of low-dose varenicline saturates α4β2* nicotinic acetylcholine receptors in the human brain. |
| Q50486216 | A test of the cognitive-enhancing potential of low-dose mecamylamine in healthy non-smokers. |
| Q38851564 | A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders. |
| Q44610975 | Acetylcholine Increases Intracellular Ca2+Via Nicotinic Receptors in Cultured PDF-Containing Clock Neurons ofDrosophila |
| Q33833510 | Activated cholinergic signaling provides a target in squamous cell lung carcinoma |
| Q36918099 | Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats |
| Q37246837 | Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats |
| Q24635028 | Acute nicotine-induced tachyphylaxis is differentially manifest in the limbic system |
| Q37363808 | Age dependent nicotinic influences over dopamine neuron synaptic plasticity |
| Q43995403 | Age-related changes in functional postsynaptic nicotinic acetylcholine receptor subunits in neurons of the laterodorsal tegmental nucleus, a nucleus important in drug addiction |
| Q35174622 | Age-related changes in nicotine response of cholinergic and non-cholinergic laterodorsal tegmental neurons: implications for the heightened adolescent susceptibility to nicotine addiction |
| Q41455560 | Alpha7 Nicotinic Acetylcholine Receptors Play a Predominant Role in the Cholinergic Potentiation of N-Methyl-D-Aspartate Evoked Firing Responses of Hippocampal CA1 Pyramidal Cells |
| Q46838520 | Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization |
| Q36185892 | Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats |
| Q51462591 | Attenuated nicotine-like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily. |
| Q24601769 | Axonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons |
| Q91906760 | Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala |
| Q37412757 | Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette |
| Q40414029 | Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones |
| Q35646004 | Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment |
| Q30363601 | Cell-Specific Cholinergic Modulation of Excitability of Layer 5B Principal Neurons in Mouse Auditory Cortex. |
| Q37247103 | Cellular events in nicotine addiction |
| Q44926271 | Cellular nicotinic receptor desensitization correlates with nicotine-induced acute behavioral tolerance in rats |
| Q40413207 | Cellular responses to nicotinic receptor activation are decreased after prolonged exposure to galantamine in human neuroblastoma cells |
| Q35034867 | Central administration of nicotine suppresses tracheobronchial cough in anesthetized cats. |
| Q37259110 | Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats |
| Q38911338 | Cholinergic Circuit Control of Postnatal Neurogenesis. |
| Q46775998 | Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study |
| Q37826637 | Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings |
| Q36248758 | Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry |
| Q37412735 | Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors |
| Q48609200 | Cognitive Effects of Nicotine: Recent Progress |
| Q64238005 | Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats |
| Q30396291 | Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking |
| Q30474904 | Cognitive effects of nicotine: genetic moderators |
| Q34110747 | Comparison of available treatments for tobacco addiction |
| Q30738165 | Comparison of effects produced by nicotine and the α4β2-selective agonist 5-I-A-85380 on intracranial self-stimulation in rats |
| Q37242643 | Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions |
| Q41974120 | Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice |
| Q35962611 | Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice |
| Q37162147 | Cytisine-based nicotinic partial agonists as novel antidepressant compounds |
| Q28595059 | Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease |
| Q48164149 | Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons |
| Q48680546 | Depolarization promotes survival of ciliary ganglion neurons by BDNF-dependent and -independent mechanisms. |
| Q35107588 | Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness |
| Q40360827 | Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine |
| Q81299349 | Development of an anti-cotinine vaccine to potentiate nicotine-based smoking cessation strategies |
| Q34017006 | Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors |
| Q44418971 | Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. |
| Q91844566 | Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors |
| Q43263076 | Donepezil modulates nicotinic receptors of substantia nigra dopaminergic neurones |
| Q22251247 | Dopamine release in the basal ganglia |
| Q37146835 | Dynamic associations of negative mood and smoking across the development of smoking in adolescence |
| Q36421837 | Dynamic structural investigations on the torpedo nicotinic acetylcholine receptor by time-resolved photoaffinity labeling |
| Q33699322 | Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging |
| Q43127109 | Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery |
| Q51840543 | Effects of chronic nicotine, nicotine withdrawal and subsequent nicotine challenges on behavioural inhibition in rats. |
| Q37352047 | Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice. |
| Q46571149 | Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers |
| Q44472573 | Electrophysiological changes in laterodorsal tegmental neurons associated with prenatal nicotine exposure: implications for heightened susceptibility to addict to drugs of abuse |
| Q44351170 | Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia |
| Q33790163 | Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia. |
| Q42919989 | Evaluation of the Effects of AZD3480 on Cardiac Repolarization: A Thorough QT/QTc Study Using Moxifloxacin as a Positive Control |
| Q44911969 | Evidence of cellular nicotinic receptor desensitization in rats exhibiting nicotine-induced acute tolerance |
| Q46929171 | Examining the risks and benefits of considering both the traditional dose--response and hormesis in arriving at an acceptable exposure level |
| Q46589823 | Examining the risks and benefits of replacing traditional dose-response with hormesis |
| Q28386015 | Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood |
| Q37384945 | Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats |
| Q93088778 | Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo |
| Q45963960 | First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. |
| Q28288721 | From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research |
| Q46365543 | Functional expression of nicotinic acetylcholine receptors in rat neocortical layer 5 pyramidal cells |
| Q31008708 | Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons. |
| Q33935259 | Gliotransmitters travel in time and space |
| Q83225289 | High fat diet induces microbiota-dependent silencing of enteroendocrine cells |
| Q35155905 | High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept |
| Q42910564 | Hippocampal alpha7 nicotinic receptors modulate memory reconsolidation of an inhibitory avoidance task in mice |
| Q38741215 | Impact of ageing on postsynaptic neuronal nicotinic neurotransmission in auditory thalamus |
| Q37326725 | In vivo effects of 3-iodocytisine: pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites |
| Q35951334 | Increased nicotinic receptor desensitization in hypoglossal motor neurons following chronic developmental nicotine exposure |
| Q37163861 | Influence of neuronal nicotinic receptors over nicotine addiction and withdrawal |
| Q46790397 | Involvement of kappa/dynorphin system in the development of tolerance to nicotine-induced antinociception |
| Q36666651 | It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood |
| Q35753943 | Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include α5 or α6 subunits and that mediate synaptosomal neurotransmitter release |
| Q35117588 | Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling |
| Q45284025 | MLA-sensitive cholinergic receptors involved in the detection of complex moving stimuli in retina |
| Q28686906 | Marine Toxins Targeting Ion Channels |
| Q36474829 | Mechanisms generating dual-component nicotinic EPSCs in cortical interneurons |
| Q35897852 | Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors |
| Q42728501 | Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function |
| Q46755446 | Mitochondrial reactive oxygen species inactivate neuronal nicotinic acetylcholine receptors and induce long-term depression of fast nicotinic synaptic transmission. |
| Q24672543 | Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells |
| Q37707591 | Modulation of nicotinic receptor channels by adrenergic stimulation in rat pinealocytes |
| Q26765419 | Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders |
| Q36562041 | Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors |
| Q27008063 | Molecules and circuits involved in nicotine addiction: The many faces of smoking |
| Q37020739 | Mood variability and cigarette smoking escalation among adolescents. |
| Q44329819 | Mu-opioid receptors are involved in the tolerance to nicotine antinociception |
| Q44350271 | Muscarinic receptors couple to modulation of nicotinic ACh receptor desensitization in myenteric neurons |
| Q35307705 | Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output |
| Q36890894 | Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity. |
| Q36490835 | Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems |
| Q37379135 | Neonicotinoid Insecticides Alter the Gene Expression Profile of Neuron-Enriched Cultures from Neonatal Rat Cerebellum |
| Q35566709 | Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses |
| Q34012381 | Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system |
| Q52606810 | Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis. |
| Q26782610 | Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine |
| Q36137598 | Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions |
| Q44646894 | Neuronal nicotinic acetylcholine receptors: not just in brain |
| Q34637004 | Neurophysiology of Nicotine Addiction |
| Q35601652 | Nicotine and Parkinson's disease: implications for therapy |
| Q36468842 | Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses |
| Q47781525 | Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression |
| Q83473801 | Nicotine effects on human endothelial intercellular communication via α4β2 and α3β2 nicotinic acetylcholine receptor subtypes |
| Q35217714 | Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences |
| Q48939912 | Nicotine induces dendritic spine remodeling in cultured hippocampal neurons |
| Q37413060 | Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. |
| Q40626831 | Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors. |
| Q30404700 | Nicotine withdrawal |
| Q46313851 | Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors |
| Q44973286 | Nicotine-induced up-regulation and desensitization of alpha4beta2 neuronal nicotinic receptors depend on subunit ratio |
| Q33620835 | Nicotine-mediated signals modulate cell death and survival of T lymphocytes |
| Q94059614 | Nicotinic Receptor Intervention in Parkinson's Disease: Future Directions |
| Q30430585 | Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors |
| Q37485939 | Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system |
| Q37629127 | Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex. |
| Q37439216 | Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission |
| Q35541262 | Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction |
| Q38116676 | Nicotinic modulation of intrinsic brain networks in schizophrenia |
| Q30993631 | Nicotinic modulation of neuronal networks: from receptors to cognition |
| Q28087047 | Nicotinic receptor modulation to treat alcohol and drug dependence |
| Q37518024 | Nicotinic receptor-based therapeutics and candidates for smoking cessation |
| Q37404292 | Nicotinic receptors and stages of nicotine dependence. |
| Q41481122 | Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion |
| Q40106439 | Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. |
| Q34264318 | Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells |
| Q91833966 | Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats |
| Q36016445 | PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization |
| Q48767121 | PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. |
| Q33222788 | Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones |
| Q41818202 | Partial agonists for α4β2 nicotinic receptors stimulate dopaminergic neuron firing with relatively enhanced maximal effects |
| Q42109872 | Partial blockade of nicotinic acetylcholine receptors improves the counterregulatory response to hypoglycemia in recurrently hypoglycemic rats |
| Q38639637 | Pharmacokinetic Limitations on Effects of an Alpha7 Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended Release Formulation |
| Q90637695 | Positive and inverse correlation of blood lead level with erythrocyte acetylcholinesterase and intelligence quotient in children: implications for neurotoxicity |
| Q42692558 | Postsynaptic nicotinic acetylcholine receptors facilitate excitation of developing CA1 pyramidal neurons. |
| Q36052452 | Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor |
| Q36949979 | Potential therapeutic uses of mecamylamine and its stereoisomers |
| Q43836090 | Preconditioning stimuli that augment chromaffin cell secretion |
| Q24617518 | Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor |
| Q28386016 | Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?" |
| Q44768750 | Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal |
| Q47614291 | Presynaptic Neuronal Nicotinic Receptors Differentially Shape Select Inputs to Auditory Thalamus and Are Negatively Impacted by Aging |
| Q37014100 | Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission |
| Q38557880 | Probing striatal microcircuitry to understand the functional role of cholinergic interneurons |
| Q37366203 | Race differences in factors relating to smoking initiation |
| Q34712523 | Receptor downregulation and desensitization enhance the information processing ability of signalling receptors |
| Q48397732 | Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse |
| Q46808065 | Region-specific effects of nicotine on brain activity: a pharmacological MRI study in the drug-naïve rat. |
| Q34768885 | Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration |
| Q37024161 | Review. Neurobiology of nicotine dependence |
| Q36323545 | Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice. |
| Q34189358 | Role of glycosylation and membrane environment in nicotinic acetylcholine receptor stability. |
| Q28271387 | Selective regulation of acid-sensing ion channel 1 by serine proteases |
| Q24645468 | Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain |
| Q34985062 | Short- and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability |
| Q44464092 | Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds |
| Q47829763 | Similar nicotinic excitability responses across the developing hippocampal formation are regulated by small conductance calcium-activated potassium channels. |
| Q30491841 | Smoking, Genetics and Schizophrenia: Evidence for Self Medication |
| Q36825487 | Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity |
| Q58591147 | Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors |
| Q39787307 | Targeting cholinesterase inhibitor poisoning with a novel blocker against both nicotinic and muscarinic receptors |
| Q26824406 | The "stop" and "go" of nicotine dependence: role of GABA and glutamate |
| Q41584797 | The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens. |
| Q34419501 | The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. |
| Q58185617 | The relationship between level of cigarette consumption and latency to the onset of retrospectively reported withdrawal symptoms |
| Q42962276 | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| Q46713909 | Timing of nicotine effects on learning in zebrafish |
| Q36927768 | Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density |
| Q89858108 | Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro-β-erythroidine in nicotine-tolerant mice |
| Q37134860 | Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers |
| Q40386589 | Use-dependent inhibition of P2X3 receptors by nanomolar agonist. |
| Q37300470 | Using MIMIC models to examine the relationship between current smoking and early smoking experiences |
| Q35761753 | Varenicline dose dependently enhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancing effects of nicotine |
| Q39105285 | Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death |
| Q90356662 | α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats |
| Q35581667 | α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties |
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