In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides

scientific article

In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.48.1.337-339.2004
P932PMC publication ID310190
P698PubMed publication ID14693562

P50authorJan BalzariniQ31332118
Luc KestensQ91181998
Guido VanhamQ115736004
P2093author name stringPaul Janssen
Katrien Fransen
Paul Lewi
Jens Van Roey
Yven Van Herrewege
Jo Michiels
P2860cites workKinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-diQ28316231
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitorsQ28377402
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptaseQ28379510
Contraceptives of the future in the light of HIV infectionQ30419155
Sexual transmission of HIV: infectiousness and preventionQ33593763
Considerations and development of topical microbicides to inhibit the sexual transmission of HIV.Q34768558
Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaquesQ36366154
PCR-Based assay to quantify human immunodeficiency virus type 1 DNA in peripheral blood mononuclear cellsQ39455247
Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmissionQ39550866
Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapyQ39625779
Attenuated infectivity of HIV type 1 from epithelial cells pretreated with a tight-binding nonnucleoside reverse transcriptase inhibitorQ40712257
The effectiveness of barrier methods of contraception in preventing the spread of HIV.Q41120010
Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent.Q42540870
Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1.Q42549326
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analoguesQ43723233
Correlation of human immunodeficiency virus type 1 RNA levels in blood and the female genital tractQ45750900
Safety Study of Nonoxynol-9 as a Vaginal Microbicide: Evidence of Adverse EffectsQ57055766
Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulationQ60267434
HIV prevention: the need for methods women can useQ68735330
Challenges for the development of female-controlled vaginal microbicidesQ72014624
Mechanisms of HIV/SIV mucosal transmissionQ72527610
Observations from the CDC. The urgent need for new HIV/STD prevention options for womenQ77712380
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)337-339
P577publication date2004-01-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleIn vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
P478volume48

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