Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin

scientific article

Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.4161/SGTP.1.3.14935
P932PMC publication ID3116608
P698PubMed publication ID21686274
P5875ResearchGate publication ID51231702

P2093author name stringDeborah N Chadee
Yu Zhan
P2860cites workThe MEK/ERK cascade: from signaling specificity to diverse functionsQ36656631
An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin).Q38304298
Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac.Q40181731
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6Q41079070
Inhibition of ras-mediated activator protein 1 activity and cell growth by merlin.Q42810181
The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activityQ42812549
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.Q42823880
Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cellsQ73424194
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferationQ24299564
Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerQ24301750
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42Q24532640
Rho GTPases: biochemistry and biologyQ27860645
Protein 4.1 tumor suppressors: getting a FERM grip on growth regulationQ28204748
Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalQ28283076
Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1Q28513718
Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 proteinQ28587255
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.Q28648056
Rho GTPases and their effector proteinsQ29547740
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.Q30160092
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domainQ30167889
Mechanism of activation of Pak1 kinase by membrane localizationQ30175873
The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.Q30176864
Tumorigenesis in neurofibromatosis: new insights and potential therapiesQ34207916
Raf proteins and cancer: B-Raf is identified as a mutational targetQ34648534
Mixed-lineage kinase control of JNK and p38 MAPK pathwaysQ34810173
Merlin and the ERM proteins in Schwann cells, neurons and growth conesQ35777641
P433issue3
P304page(s)183-186
P577publication date2010-11-01
P1433published inSmall GTPases (journal)Q15709529
P1476titleInhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin
P478volume1

Reverse relations

cites work (P2860)
Q36249781A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma
Q38447137Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling
Q38102775Involvement of mixed lineage kinase 3 in cancer
Q26746892MLK3 Signaling in Cancer Invasion
Q42122417Novel age-dependent targets in vestibular schwannomas.

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