meta-analysis | Q815382 |
scholarly article | Q13442814 |
P50 | author | John Ioannidis | Q6251482 |
Despina Contopoulos-Ioannidis | Q29870901 | ||
Evangelia Ntzani | Q50076817 | ||
Thomas Trikalinos | Q60056375 | ||
P2860 | cites work | A comprehensive review of genetic association studies | Q22337119 |
Searching for genetic determinants in the new millennium | Q22337300 | ||
Evolution of treatment effects over time: empirical insight from recursive cumulative metaanalyses | Q24289247 | ||
Bias in meta-analysis detected by a simple, graphical test | Q24685585 | ||
Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis | Q27860511 | ||
Operating characteristics of a rank correlation test for publication bias | Q27860653 | ||
Meta-analysis in clinical trials | Q27860779 | ||
Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis | Q28189245 | ||
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms | Q28203288 | ||
The future of genetic studies of complex human diseases | Q29547215 | ||
Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature | Q29614233 | ||
Quantitative Synthesis in Systematic Reviews | Q29614894 | ||
Replication validity of genetic association studies | Q29615456 | ||
Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. | Q30664904 | ||
Commentary: meta-analysis of individual participants' data in genetic epidemiology | Q30707324 | ||
Association studies of genetic polymorphisms and complex disease | Q33838028 | ||
Large upward bias in estimation of locus-specific effects from genomewide scans | Q34044873 | ||
Association study designs for complex diseases | Q34186026 | ||
Quantitative methods in the review of epidemiologic literature | Q34187297 | ||
Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis | Q34307827 | ||
Large trials vs meta-analysis of smaller trials: how do their results compare? | Q40923138 | ||
Publication bias: the problem that won't go away. | Q41056991 | ||
Cumulative meta-analysis of therapeutic trials for myocardial infarction | Q41112231 | ||
On the use of familial aggregation in population-based case probands for calculating penetrance | Q50109259 | ||
A comparison of methods to detect publication bias in meta-analysis | Q52067551 | ||
Summing up evidence: one answer is not always enough | Q52900179 | ||
Issues in Comparisons Between Meta-analyses and Large Trials | Q52901853 | ||
Human genome epidemiologic reviews: the beginning of something HuGE | Q73333358 | ||
Effect of the Statistical Significance of Results on the Time to Completion and Publication of Randomized Efficacy Trials | Q74121809 | ||
Clinical epidemiological quality in molecular genetic research: the need for methodological standards | Q77816185 | ||
P433 | issue | 9357 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 567-571 | |
P577 | publication date | 2003-02-01 | |
P13046 | publication type of scholarly work | review article | Q7318358 |
P1433 | published in | The Lancet | Q939416 |
P1476 | title | Genetic associations in large versus small studies: an empirical assessment | |
P478 | volume | 361 |
Q30334349 | "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. |
Q44586727 | 'Racial' differences in genetic effects for complex diseases |
Q35406944 | A Review of Genetic Association Studies of Obstructive Sleep Apnea: Field Synopsis and Meta-Analysis |
Q42907920 | A fast method for computing high-significance disease association in large population-based studies |
Q28274390 | A heterogeneity-based genome search meta-analysis for autism-spectrum disorders |
Q51935792 | A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia |
Q88173475 | A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in breast cancer |
Q33447663 | A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128. |
Q44506552 | A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese. |
Q40284668 | A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer |
Q36492170 | A randomization test for controlling population stratification in whole-genome association studies |
Q30230101 | A research agenda for assessing the potential contribution of genomic medicine to tobacco control |
Q53072839 | A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: Collaborative of 53 studies with 20,435 cases and 23,674 controls |
Q28307159 | ADAM33 expression in asthmatic airways and human embryonic lungs |
Q35605265 | Advances in pharmacogenomic research and development |
Q52970838 | Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis |
Q46653214 | An association study of 43 SNPs in 16 candidate genes with atorvastatin response |
Q33235613 | Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases |
Q33267837 | Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias |
Q36952959 | Assessment of cumulative evidence on genetic associations: interim guidelines |
Q56880239 | Assessment of systematic effects of methodological characteristics on candidate genetic associations |
Q36022021 | Association between Polymorphisms in Interleukins 4 and 13 Genes and Chronic Periodontitis in a Han Chinese Population |
Q34646739 | Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: A meta-analysis |
Q86040752 | Association between polymorphisms in PDCD1 gene and aplastic anemia in Chinese Han population |
Q45245187 | Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis |
Q26859762 | Association of Plasminogen Activator Inhibitor-Type 1 (-675 4G/5G) Polymorphism with Pre-Eclampsia: Systematic Review |
Q46114358 | Association of Tumor Necrosis Factor-α Gene G-308A Polymorphism with Dilated Cardiomyopathy: A Meta-Analysis |
Q39820068 | Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine |
Q57089320 | Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease |
Q81390426 | Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women |
Q79435087 | Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis |
Q35062755 | Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach |
Q53005037 | Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis |
Q33653008 | Association of the apolipoprotein A5 gene -1131 T>C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects |
Q38815988 | Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis |
Q36998131 | Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. |
Q36295552 | Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis |
Q38028871 | Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder |
Q46959437 | C-588T polymorphism of the human glutamate-cysteine ligase modifier subunit gene is not associated with the risk and extent of ischemic heart disease in a German cohort |
Q44828143 | CC-chemokine receptor five gene polymorphism in primary IgA nephropathy: the 32 bp deletion allele is associated with late progression to end-stage renal failure with dialysis |
Q46772328 | CD14 and TLR4 gene polymorphisms in adult periodontitis |
Q34426642 | COMT polymorphisms and anxiety-related personality traits |
Q36079873 | CTLA4 gene polymorphism and autoimmunity |
Q37117080 | Calibration of credibility of agnostic genome-wide associations |
Q22252698 | Candidate gene studies of ADHD: a meta-analytic review |
Q38010012 | Challenges in reproducibility of genetic association studies: lessons learned from the obesity field |
Q35621396 | Challenges of implementing pharmacogenetics in the critical care environment |
Q36667220 | Chromogranin A polymorphisms are associated with hypertensive renal disease. |
Q33318443 | Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis |
Q47285235 | Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation |
Q36906418 | Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population |
Q37155532 | Consortium analysis of 7 candidate SNPs for ovarian cancer |
Q27003308 | Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals |
Q84596776 | Correlating of GSTM1, GSTT1, and GSTP1 genetic polymorphisms with the risk and expressions in children with isolated Hirschsprung disease |
Q47929552 | Cost-effective analysis of candidate genes using htSNPs: a staged approach |
Q41913384 | Credible genetic associations? |
Q48887107 | Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery |
Q52970473 | Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis |
Q33240464 | Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes |
Q36039820 | Disease-specific target selection: a critical first step down the right road |
Q90599510 | Dissociation of BDNF Val66Met polymorphism on neurocognitive functioning in military veterans with and without a history of remote mild traumatic brain injury |
Q43818808 | Distribution of ABO blood groups in childhood acute leukemia |
Q42331977 | Don't forget the "single chromosome polymorphism": a need for gender-stratification in pediatric patients? |
Q36098299 | Dopamine D4 receptor gene and religious affiliation correlate with dictator game altruism in males and not females: evidence for gender-sensitive gene × culture interaction |
Q24245819 | Dopaminergic agonists for hepatic encephalopathy |
Q37900131 | Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective. |
Q80937177 | Editorial foreword |
Q52971041 | Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study). |
Q36809759 | Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis. |
Q39218509 | Establishment of genetic associations for complex diseases is independent of early study findings |
Q36369963 | Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology |
Q37879748 | Evolving Knowledge of Opioid Genetics in Cancer Pain |
Q83564385 | FCRL3 gene polymorphisms contribute to the radiographic severity rather than susceptibility of rheumatoid arthritis |
Q21563421 | Factors associated with findings of published trials of drug-drug comparisons: why some statins appear more efficacious than others |
Q33326760 | Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD |
Q24289182 | False-positive results in cancer epidemiology: a plea for epistemological modesty |
Q33253242 | Family-based versus unrelated case-control designs for genetic associations |
Q42535981 | Food science and food ingredients: the need for reliable scientific approaches and correct communication, Florence, 24 March 2015. |
Q47999943 | Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies |
Q60670847 | From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions |
Q21091172 | Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies |
Q46843574 | GST Theta null genotype is associated with an increased risk for ulcerative colitis: a case-control study and meta-analysis of GST Mu and GST Theta polymorphisms in inflammatory bowel disease |
Q33892560 | Gene by social context interactions for number of sexual partners among white male youths: genetics-informed sociology |
Q35878266 | Gene expression profiling for molecular staging and prognosis prediction in colorectal cancer. |
Q56058488 | Genetic aspects of osteoporosis |
Q37149581 | Genetic association analysis of vitamin D pathway with obesity traits. |
Q36267276 | Genetic association studies |
Q36142031 | Genetic association studies of complex neurological diseases |
Q82422603 | Genetic association studies: personalized medicine in cardiac transplantation |
Q35119636 | Genetic associations: false or true? |
Q35688722 | Genetic epidemiology and primary care |
Q36293973 | Genetic epidemiology and public health: hope, hype, and future prospects |
Q22330767 | Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities. Background Document to the ESHG recommendations on genetic testing and common disorders |
Q36309653 | Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms |
Q36103109 | Genetics of Type 2 diabetes. |
Q37977017 | Genetics of age at menarche: a systematic review |
Q44992368 | Genetics of endometriosis: a role for the progesterone receptor gene polymorphism PROGINS? |
Q39714368 | Genetics of muscle strength and power: polygenic profile similarity limits skeletal muscle performance. |
Q34458072 | Genetics of the Framingham Heart Study population |
Q37806616 | Genome-wide association studies and genetic risk assessment of liver diseases |
Q34218368 | Genome-wide association studies of hypertension: light at the end of the tunnel |
Q34555195 | Genome-wide association studies: theoretical and practical concerns |
Q34949154 | Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study |
Q34626602 | Guidelines on the irritable bowel syndrome: mechanisms and practical management. |
Q34612338 | HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies |
Q46477695 | Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. |
Q46523656 | Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic beta2 receptor in a Swedish hypertensive population. |
Q36475057 | Hardy-Weinberg analysis of a large set of published association studies reveals genotyping error and a deficit of heterozygotes across multiple loci |
Q36992568 | Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls |
Q83748046 | IL-1-polymorphism and severity of periodontal disease |
Q36243416 | Identification of genetic risk factors for periodontitis and possible mechanisms of action |
Q35037456 | Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing |
Q37138039 | Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism |
Q38421814 | Illumina DNA test panel-based genotyping of whole genome amplified-DNA extracted from hair samples: performance and agreement with genotyping results from genomic DNA from buccal cells |
Q57542910 | Impact of Violations and Deviations in Hardy-Weinberg Equilibrium on Postulated Gene-Disease Associations |
Q33348834 | Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk |
Q53008274 | Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases |
Q33841650 | Influence of PARP-1 polymorphisms in patients after traumatic brain injury |
Q36739907 | Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases |
Q39512293 | Interaction of C1GALT1-IL5RA on the susceptibility to IgA nephropathy in Southern Han Chinese. |
Q57329877 | Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans |
Q24802893 | Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping |
Q85631567 | Irritable bowel syndrome and inflammatory bowel disease: infectious gastroenteritis-related disorders? |
Q58182931 | Is TOR1A a risk factor in adult-onset primary torsion dystonia? |
Q58125365 | Lack of association between APOE gene polymorphisms and amyotrophic lateral sclerosis: A comprehensive meta-analysis |
Q38307513 | Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients. |
Q35053963 | Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes |
Q57121889 | Large-Scale Zygosity Testing Using Single Nucleotide Polymorphisms |
Q56109998 | Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men |
Q53845662 | Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes. |
Q44982600 | Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion |
Q28395123 | Lead and delta-aminolevulinic acid dehydratase polymorphism: where does it lead? A meta-analysis |
Q21563436 | Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature |
Q33942274 | Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms |
Q63916541 | Making the right associations |
Q24805844 | Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites |
Q50867647 | Meta-Analysis of the Association Between Urokinase-Plasminogen Activator Gene rs2227564 Polymorphism and Alzheimer’s Disease |
Q33276409 | Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease |
Q37115919 | Meta-analysis methods |
Q42067542 | Meta-analysis of candidate gene effects using bayesian parametric and non-parametric approaches |
Q24288971 | Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature |
Q83653839 | Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility |
Q90458146 | Model-based QTL detection is sensitive to slight modifications in model formulation |
Q35626453 | Molecular basis and genetic predisposition to intracranial aneurysm |
Q43959142 | Molecular bias |
Q35691688 | Molecular genetic studies of gene identification for osteoporosis: a 2004 update |
Q37466914 | Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2). |
Q33420094 | Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans |
Q34989610 | Neural reactivity to monetary rewards and losses in childhood: longitudinal and concurrent associations with observed and self-reported positive emotionality |
Q35946291 | New perspectives for the elucidation of genetic disorders |
Q42476988 | No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort |
Q24288724 | No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences |
Q40346323 | No association between selected candidate gene polymorphisms and severe chronic periodontitis |
Q56901537 | No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis |
Q33938685 | No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes |
Q36841272 | Non-replication and inconsistency in the genome-wide association setting |
Q33410654 | Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry |
Q53348079 | Nutrigenomics, individualism and public health |
Q36011593 | Obstacles and opportunities in meta-analysis of genetic association studies. |
Q40477448 | Overdispersion of allele frequency differences between populations: implications for meta-analyses of genotypic disease associations. |
Q35041179 | PAI-1 -675 4G/5G polymorphism in association with diabetes and diabetic complications susceptibility: a meta-analysis study |
Q33999587 | Panic disorder |
Q57116488 | Paraoxonase 2 (PON2) polymorphisms and development of renal dysfunction in type 2 diabetes: UKPDS 76 |
Q36148396 | Paths to understanding the genetic basis of autoimmune disease |
Q33328503 | Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis |
Q35828913 | Periodontal epidemiology: towards social science or molecular biology? |
Q37880875 | Pharmacogenetics of Drug Transporters in the Enterohepatic Circulation |
Q36918110 | Pharmacogenetics of the response to beta 2 agonist drugs: a systematic overview of the field |
Q37178537 | Pharmacogenetics studies in STAR*D: strengths, limitations, and results |
Q35130401 | Physical activity and asthma symptoms among New York City Head Start Children |
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Q92626591 | Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization |
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Q44143261 | Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis |
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Q35577543 | Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment |
Q35166637 | Principles in genetic risk assessment |
Q35038066 | Prospects and pitfalls in whole genome association studies |
Q36527065 | Prothrombotic gene variants as risk factors of acute myocardial infarction in young women |
Q54286948 | RNA biomarkers in colorectal cancer. |
Q38571344 | Randomized controlled trials and neuro-oncology: should alternative designs be considered? |
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Q28597442 | Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases |
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Q44290698 | Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts |
Q33336256 | Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment |
Q36392953 | Required sample size and nonreplicability thresholds for heterogeneous genetic associations |
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Q24288769 | Selection in reported epidemiological risks: an empirical assessment |
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Q36102529 | Simple f test reveals gene-gene interactions in case-control studies |
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Q43813559 | Social networking and personal genomics: suggestions for optimizing the interaction |
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